Abstract: The present disclosure provides, inter alia, antibody-drug conjugates that are useful in treating various diseases such as cancer.

Abstract: The present disclosure relates to compositions including metal-organic framework materials and a polymeric binder. The compositions may have a crush strength of about 2.5 lb-force or greater. The present disclosure also relates to processes for producing metal-organic framework extrudates. Processes may include mixing a metal-organic framework material, a polymeric binder, and optionally a solvent to form a mixture. The process may also include extruding the mixture to form a metal-organic framework extrudate.

Abstract: Methods and systems for positioning audio signals on virtual soundstages. The mobile device may include one or more orientation components that are used to generate orientation data that track directional changes that are used to position an audio signal on a virtual soundstage. A listener of the sound from the audio signal may be associated with the orientation data such that the positioning of the audio signal provides virtual acoustic presence on the virtual soundstage. The audio signal is received, the audio signal may be associated with a plurality audio channels. The orientation data for positioning the audio signal is also received. A position for the audio signal on the virtual soundstage is determined based in part on the orientation data. The audio signal is then positioned on the virtual soundstage.

Abstract: A water resistant port and a method for using it are provided. The port comprises a moveable seal assembly coupled to a spring structure. The moveable seal assembly may comprise a plastic material on an inner surface and a seal material on an outer surface. When the spring structure is in a relaxed position, the moveable seal assembly is caused to create a seal with a gasket material coupled to a side wall of a port casing. The spring structure comprises a spring coupled to the moveable seal assembly at one end and to a guide at an opposite end in an interior portion of the port casing. The port casing comprises, on an interior surface, one or more electrical connectors adapted to receive one or more electrical contacts of an accessory plug when the spring structure is compressed and the moveable seal assembly is in an engaged position.

Abstract: A water resistant port and a method for using it are provided. The port comprises a moveable seal assembly coupled to a spring structure. The moveable seal assembly may comprise a plastic material on an inner surface and a seal material on an outer surface. When the spring structure is in a relaxed position, the moveable seal assembly is caused to create a seal with a gasket material coupled to a side wall of a port casing. The spring structure comprises a spring coupled to the moveable seal assembly at one end and to a guide at an opposite end in an interior portion of the port casing. The port casing comprises, on an interior surface, one or more electrical connectors adapted to receive one or more electrical contacts of an accessory plug when the spring structure is compressed and the moveable seal assembly is in an engaged position.

Abstract: An information element to be published is first associated with a first network addressable location of a communications network. A repository arrangement programmed in a computer receives the information element to be published and stores the information element at a second network addressable location. The computer implementing the repository arrangement is connected to the communications network. When the information element is stored by the repository arrangement, a handle production arrangement programmed in the computer produces a repository handle for the information element. The repository handle includes identifying information relating to the information element to be published and information from which a network address for the second network addressable location may be produced. An information organizing arrangement programmed in the computer retrieves the repository handle for the information element to be published and stores the repository handle under a first network addressable location.