Patents by Inventor Patrick J. Lager

Patrick J. Lager has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR IN VIVO IDENTIFICATION OF ENDOGENOUS MRNA TARGETS OF MICRORNAS
    Publication number: 20170327866
    Abstract: A method of generating a gene expression profile of noncoding regulatory RNA (ncRNA; e.g. a microRNA) in a cell in vivo, is carried out by: (a) partitioning from a cell at least one mRNA-protein (RNP) complex, the RNP complex comprising: (i) an RNA binding protein (RNABP) or RNA associated protein, (ii) at least one mRNA bound to or associated with said protein, and (iii) at least one ncRNA bound to or associated with said protein, and then (b) identifying at least one ncRNA in at least one RNP complex, thereby to produce a gene expression profile comprising the identity of an ncRNA in an RNP complex.
    Type: Application
    Filed: April 6, 2017
    Publication date: November 16, 2017
    Inventors: Jack D. Keene, Patrick J. Lager
  • Methods for in vivo identification of endogenous mRNA targets of MicroRNAs
    Patent number: 9617581
    Abstract: A method of generating a gene expression profile of noncoding regulatory RNA (ncRNA; e.g. a microRNA) in a cell in vivo, is carried out by: (a) partitioning from a cell at least one mRNA-protein (RNP) complex, the RNP complex comprising: (i) an RNA binding protein (RNABP) or RNA associated protein, (ii) at least one mRNA bound to or associated with said protein, and (iii) at least one ncRNA bound to or associated with said protein, and then (b) identifying at least one ncRNA in-at least one RNP complex, thereby to produce a gene expression profile comprising the identity of an ncRNA in an RNP complex.
    Type: Grant
    Filed: August 24, 2007
    Date of Patent: April 11, 2017
    Assignee: Duke University
    Inventors: Jack D. Keene, Patrick J. Lager
  • Methods for In Vivo Identification of Endogenous mRNA Targets of MicroRNAs
    Publication number: 20100267573
    Abstract: A method of generating a gene expression profile of noncoding regulatory RNA (ncRNA; e.g. a microRNA) in a cell in vivo, is carried out by: (a) partitioning from a cell at least one mRNA-protein (RNP) complex, the RNP complex comprising: (i) an RNA binding protein (RNABP) or RNA associated protein, (ii) at least one mRNA bound to or associated with said protein, and (iii) at least one ncRNA bound to or associated with said protein, and then (b) identifying at least one ncRNA in-at least one RNP complex, thereby to produce a gene expression profile comprising the identity of an ncRNA in an RNP complex.
    Type: Application
    Filed: August 24, 2007
    Publication date: October 21, 2010
    Inventors: Jack D. Keene, Patrick J. Lager