Patents by Inventor Patrick J. O'Hara

Patrick J. O'Hara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20030166070
    Abstract: Human phermones may be used to alleviate anxiety, promote beneficial moods, and to alter hypothalamic functions, such as satiety, energy balance, and reproductive biology. The present invention provides a new group of human pheromone polypeptides, collectively designated “ZHMUP-1.
    Type: Application
    Filed: May 9, 2002
    Publication date: September 4, 2003
    Inventors: Si Lok, James L. Holloway, Patrick J. O'Hara
  • Publication number: 20030100047
    Abstract: Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in testis cells. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of testis cells, and may also be used in the development of male-specific contraceptives and infertility treatments.
    Type: Application
    Filed: June 4, 1998
    Publication date: May 29, 2003
    Inventors: JAMES W. BAUMGARTNER, THERESA M. FARRAH, DONALD C. FOSTER, FRANK J. GRANT, PATRICK J. O'HARA
  • Publication number: 20030100046
    Abstract: Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in testis cells. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of testis cells, and may also be used in the development of male-specific contraceptives and infertility treatments.
    Type: Application
    Filed: March 12, 1997
    Publication date: May 29, 2003
    Inventors: JAMES W. BAUMGARTNER, THERESA M. FARRAH, DONALD C. FOSTER, FRANK J. GRANT, PATRICK J. O'HARA
  • Publication number: 20020137159
    Abstract: Human phermones may be used to alleviate anxiety, promote beneficial moods, and to alter hypothalamic functions, such as satiety, energy balance, and reproductive biology. The present invention provides a new group of human pheromone polypeptides, collectively designated “ZHMUP-1.
    Type: Application
    Filed: August 22, 2001
    Publication date: September 26, 2002
    Inventors: Si Lok, James L. Holloway, Patrick J. O'Hara
  • Patent number: 6025176
    Abstract: Human pancreatic islet cell glutamic acid decarboxylase (GAD), an autoantigen involved in the development of insulin-dependent diabetes mellitus (IDDM), has been cloned, sequenced and expressed by recombinant means. Recombinant human islet cell GAD polypeptides and antibodies specific to the GAD polypeptides can be used in methods of diagnosis and treatment, including use in immunoadsorptive therapy and the induction of immune tolerance.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: February 15, 2000
    Assignee: The Board of Regents of the University of Washington and ZymoGenetics, Inc.
    Inventors: Ake Lernmark, Allan E. Karlsen, Catherine E. Grubin, William Hagopian, Patrick J. O'Hara, Donald C. Foster
  • Patent number: 5952011
    Abstract: Human prostatic and placental transglutaminases are identified and cloned. The human transglutaminases herein are useful for, inter alia, therapeutic wound repair, closure of skin grafts, stabilizing food preparations, and markers for identifying agents which act as agonists or antagonists of cellular apoptosis.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: September 14, 1999
    Assignee: ZymoGenetics, Inc.
    Inventors: Patrick J. O'Hara, Francis J. Grant, Paul O. Sheppard
  • Patent number: 5919635
    Abstract: The present invention provides isolated DNA molecules comprising a DNA segment encoding a glucagon receptor. Also provided are DNA constructs comprising a first DNA segment encoding a glucagon receptor operably linked to additional DNA segments required for the expression of the first DNA segment, as well as host cells containing such DNA constructs.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: July 6, 1999
    Assignee: ZymoGenetics, Inc.
    Inventors: Wayne R. Kindsvogel, Laura J. Jelinek, Paul O. Sheppard, Francis J. Grant, Joseph L. Kuijper, Donald C. Foster, Si Lok, Patrick J. O'Hara
  • Patent number: 5792620
    Abstract: Human pancreatic islet cell glutamic acid decarboxylase (GAD), an autoantigen involved in the development of insulin-dependent diabetes mellitus (IDDM), has been cloned, sequenced and expressed by recombinant means. Recombinant human islet cell GAD polypeptides and antibodies specific to the GAD polypeptides can be used in methods of diagnosis and treatment, including use in immunoadsorptive therapy and the induction of immune tolerance.
    Type: Grant
    Filed: August 17, 1993
    Date of Patent: August 11, 1998
    Assignees: The Board of Regents of the University of Washington, ZymoGenetics, Inc.
    Inventors: Ake Lernmark, Allan E. Karlsen, Catherine E. Grubin, William Hagopian, Patrick J. O'Hara, Donald C. Foster
  • Patent number: 5776725
    Abstract: The present invention provides isolated DNA molecules comprising a DNA segment encoding a glucagon receptor. Also provided are DNA constructs comprising a first DNA segment encoding a glucagon receptor operably linked to additional DNA segments required for the expression of the first DNA segment, as well as host cells containing such DNA constructs.
    Type: Grant
    Filed: July 1, 1993
    Date of Patent: July 7, 1998
    Assignee: ZymoGenetics, Inc.
    Inventors: Wayne R. Kindsvogel, Laura J. Jelinek, Paul O. Sheppard, Francis J. Grant, Joseph L. Kuijper, Donald C. Foster, Si Lok, Patrick J. O'Hara
  • Patent number: 5770445
    Abstract: The present invention provides isolated DNA molecules comprising a DNA segment encoding a glucagon receptor. Also provided are DNA constructs comprising a first DNA segment encoding a glucagon receptor operably linked to additional DNA segments required for the expression of the first DNA segment, as well as host cells containing such DNA constructs.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: June 23, 1998
    Assignee: ZymoGenetics, Inc.
    Inventors: Wayne R. Kindsvogel, Laura J. Jelinek, Paul O. Sheppard, Francis J. Grant, Joseph L. Kuijper, Donald C. Foster, Si Lok, Patrick J. O'Hara
  • Patent number: 5514579
    Abstract: Human prostatic and placental transglutaminases are identified and cloned. The human transglutaminases herein are useful for, inter alia, therapeutic wound repair, closure of skin grafts, stabilizing food preparations, and markers for identifying agents which act as agonists or antagonists of cellular apoptosis.
    Type: Grant
    Filed: December 30, 1992
    Date of Patent: May 7, 1996
    Assignee: Zymogenetics, Inc.
    Inventors: Patrick J. O'Hara, Francis J. Grant, Paul O. Sheppard
  • Patent number: 5403734
    Abstract: A plasminogen activator comprising a growth factor domain, a kringle domain and a serine protease domain is disclosed. The growth factor domain contains a plurality of substitutions of substantially consecutive amino acids as compared to the growth factor domain of native t-PA, the substitutions resulting in an increase in plasma half-life.
    Type: Grant
    Filed: October 15, 1991
    Date of Patent: April 4, 1995
    Assignee: ZymoGenetics, Inc.
    Inventors: Eileen R Mulvihill, Patrick J. O'Hara
  • Patent number: 5281520
    Abstract: Methods are disclosed for producing acyloxyacyl hydrolase. The protein is produced from eukaryotic host cells transformed or transfected with DNA construct(s) containing information necessary to direct the expression of acyloxyacyl hydrolase. The DNA constructs generally include the following operably linked elements: a transcriptional promoter; DNA sequence encoding acyloxyacyl hydrolase, the small subunit of acyloxyacyl hydrolase or the large subunit of acyloxyacyl hydrolase; and a transcriptional terminator. In addition, isolated DNA sequences encoding acyloxyacyl hydrolase and isolated DNA sequences encoding the small or large subunit of acyloxyacyl hydrolase are disclosed.
    Type: Grant
    Filed: September 12, 1990
    Date of Patent: January 25, 1994
    Assignees: ZymoGenetics, Inc., Board of Regents University of Texas System
    Inventors: Patrick J. O'Hara, Frederick S. Hagen, Francis J. Grant, Robert S. Munford
  • Patent number: 5200340
    Abstract: Zymogens of proteins having fibrinolytic activity are disclosed. The proteins are cleavable by thrombin, the cleavage resulting in the stimulation of fibrinolytic activity. Suitable proteins which may be modified in accordance with the present invention include tissue plasminogen activator, urokinase, and plasminogen variants. The modified molecules are substantially clot-specific, in view of the large amounts of thrombin associated with clots in vivo.
    Type: Grant
    Filed: May 22, 1987
    Date of Patent: April 6, 1993
    Assignee: ZymoGenetics, Inc.
    Inventors: Donald C. Foster, Eileen R. Mulvihill, Patrick J. O'Hara, Kurt Pingel, Shinji Yoshitake
  • Patent number: 5149088
    Abstract: A one-piece flexible device for the teeing of golf balls, consisting of a larger-than-average circular concave head which narrows into an elliptically shaped blade. The shape creates a unilinear flex which arcs toward the target, allowing a more controlled tee shot. The tee has sharp edges and pointed tail which allow it to function as a clubhead cleaning device.
    Type: Grant
    Filed: March 21, 1991
    Date of Patent: September 22, 1992
    Inventor: Patrick J. O'Hara
  • Patent number: D360919
    Type: Grant
    Filed: May 8, 1992
    Date of Patent: August 1, 1995
    Inventor: Patrick J. O'Hara