Patents by Inventor Patrick J. Oriel
Patrick J. Oriel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6344350Abstract: A novel isolate of Bacillus isolated from white pine is described. The isolate is used to produce monoterpene derivatives. Also described is a pinene hydroxylase enzyme from the isolate. The enzyme is a general allylic oxidizer.Type: GrantFiled: October 26, 1999Date of Patent: February 5, 2002Assignee: Board of Trustees of Michigan State UniversityInventors: Patrick J. Oriel, Natarajan S. Savithiry, Weijie Fu
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Patent number: 6287828Abstract: A process for the bioconversion of a nitrile to its corresponding amide product, particularly acrylonitrile to acrylamide which is used for forming polymers. The process uses a thermophilic bacterium having a nitrile hydratase activity that is constitutively expressed, activated by cobalt ions, stable at 60° C., and is most active between 20° C. to 70° C. with optimum activity at 55° C. Alternatively, the process uses the enzyme extracted from the thermophilic bacterium to convert a nitrile to its amide product. The genes encoding nitrile hydratase and amidase are described in which the former is useful for the conversion of an nitrile to its amide and the later is useful for the conversion of an amide to its acid.Type: GrantFiled: April 14, 2000Date of Patent: September 11, 2001Assignee: Board of Trustees operating Michigan State UniversityInventors: Patrick J. Oriel, Rugmini Padmakumar, Sang Hoon Kim
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Patent number: 6242242Abstract: A process for the bioconversion of a nitrile to its corresponding amide product, particularly acrylonitrile to acrylamide which is used for forming polymers. The process uses a thermophilic bacterium having a nitrile hydratase activity that is constitutively expressed, activated by cobalt ions, stable at 60° C., and is most active between 20° C. to 70° C. with optimum activity at 55° C. Alternatively, the process uses the enzyme extracted from the thermophilic bacterium to convert a nitrile to its amide product. The genes encoding nitrile hydratase and amidase are described in which the former is useful for the conversion of an nitrile to its amide and the later is useful for the conversion of an amide to its acid.Type: GrantFiled: April 13, 2000Date of Patent: June 5, 2001Assignee: Board of Trustees operating Michigan State UniversityInventors: Patrick J. Oriel, Rugmini Padmakumar, Sang Hoon Kim
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Patent number: 6228633Abstract: A process for the bioconversion of a nitrile to its corresponding amide product, particularly acrylonitrile to acrylamide which is used for forming polymers. The process uses a thermophilic bacterium having a nitrile hydratase activity that is constitutively expressed, activated by cobalt ions, stable at 60° C., and is most active between 20° C. to 70° C. with optimum activity at 55° C. Alternatively, the process uses the enzyme extracted from the thermophilic bacterium to convert a nitrile to its amide product. The genes encoding nitrile hydratase and amidase are described in which the former is useful for the conversion of an nitrile to its amide and the later is useful for the conversion of an amide to its acid.Type: GrantFiled: April 13, 2000Date of Patent: May 8, 2001Assignee: Board of Trustees operating Michigan State UniversityInventors: Patrick J. Oriel, Rugmini Padmakumar, Sang Hoon Kim
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Patent number: 6214603Abstract: A process for the bioconversion of a nitrile to its corresponding amide product, particularly acrylonitrile to acrylamide which is used for forming polymers. The process uses a thermophilic bacterium having a nitrile hydratase activity that is constitutively expressed, activated by cobalt ions, stable at 60° C., and is most active between 20° C. to 70° C. with optimum activity at 55° C. Alternatively, the process uses the enzyme extracted from the thermophilic bacterium to convert a nitrile to its amide product. The genes encoding nitrile hydratase and amidase are described in which the former is useful for the conversion of an nitrile to its amide and the later is useful for the conversion of an amide to its acid.Type: GrantFiled: April 13, 2000Date of Patent: April 10, 2001Assignee: Board of Trustees operating Michigan State UniversityInventors: Patrick J. Oriel, Rugmini Padmakumar, Sang Hoon Kim
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Patent number: 6156533Abstract: A novel isolate of Bacillus isolated from white pine is described. The isolate is used to produce monoterpene derivatives. Also described is a pinene hydroxylase enzyme from the isolate. The enzyme is a general allylic oxidizer.Type: GrantFiled: May 14, 1998Date of Patent: December 5, 2000Assignee: Board of Trustees Operating Michigan State UniversityInventors: Patrick J. Oriel, Natarajan S. Savithiry, Weijie Fu
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Patent number: 6153415Abstract: A process for the bioconversion of a nitrile to its corresponding amide product, particularly acrylonitrile to acrylamide which is used for forming polymers. The process uses a thermophilic bacterium having a nitrile hydratase activity that is constitutively expressed, activated by cobalt ions, stable at 60.degree. C., and is most active between 20.degree. C. to 70.degree. C. with optimum activity at 55.degree. C. Alternatively, the process uses the enzyme extracted from the thermophilic bacterium to convert a nitrile to its amide product. The genes encoding nitrile hydratase and amidase are described in which the former is useful for the conversion of an nitrile to its amide and the later is useful for the conversion of an amide to its acid.Type: GrantFiled: February 10, 1999Date of Patent: November 28, 2000Assignee: Board of Trustees operating Michigan State UniversityInventors: Patrick J. Oriel, Rugmini Padmakumar, Sang Hoon Kim
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Patent number: 5834297Abstract: A method for the production of indigo and indirubin dyes using a recombinant Escherichia coli containing a gene encoding a phenol hydroxylase from Bacillus stearothermophilus. The dyes are used for coloring cloth and the like.Type: GrantFiled: June 16, 1997Date of Patent: November 10, 1998Assignee: Board of Trustees operating Michigan State UniversityInventors: Patrick J. Oriel, In Cheol Kim
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Patent number: 5763237Abstract: Enzymatic microbial degradation of limonene with simultaneous extraction of the degradation products with a non-water miscible organic solvent is described. Microbial degradation at elevated temperatures employing both an aqueous phase containing limonene and a neat limonene phase produced .alpha.-terpineol with additional production of carvone.Type: GrantFiled: May 16, 1997Date of Patent: June 9, 1998Assignee: Board of Trustees operating Michigan State UniversityInventors: Natarajan Savithiry, Patrick J. Oriel
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Patent number: 5691171Abstract: A method for the production of indigo and indirubin dyes using a recombinant Escherichia coli containing a gene encoding a phenol hydroxylase from Bacillus stearothermophilus. The dyes are used for coloring cloth and the like.Type: GrantFiled: October 23, 1995Date of Patent: November 25, 1997Assignee: Board of Trustees operating Michigan State UniversityInventors: Patrick J. Oriel, In Cheol Kim
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Patent number: 5688673Abstract: A process for producing monoterpenes using a DNA segment Bacillus stearothermophilus in a recombinant bacterium, particularly Escherichia coli. The useful monoterpenes produced from limonene are perillyl alcohol, perillyl aldehyde, perillic acid (path A); alpha-terpineol (path B) or carveol and carvone (path C).Type: GrantFiled: July 28, 1995Date of Patent: November 18, 1997Assignee: Board of Trustees operating Michigan State UniversityInventors: Patrick J. Oriel, Srinivasan Savithiry, Hae Choon Chang
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Patent number: 5652137Abstract: A process for the preparation of monoterpene compounds (such as perillyl alcohol, aldehyde and .alpha.-terpineol) from limonene is described. The process uses Bacillus stearothermophilus which is effective at high temperatures (55.degree. to 70.degree. C.).Type: GrantFiled: September 5, 1995Date of Patent: July 29, 1997Assignee: Board of Trustees operating Michigan State UniversityInventors: Hae Choon Chang, Patrick J. Oriel
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Patent number: 5571873Abstract: A new thermoplastic homopolymer of o-cresol which is a poly(2-methylphenylene oxide) having a high molecular weight distribution is described. The polymer is prepared using a 2 and/or 6 substituted pyridine catalyst to the molecular weight distribution. The homopolymer can be blended with other thermoplastic polymers. The homopolymer is rapidly biodegraded, particularly in soil containing soil microorganisms.Type: GrantFiled: June 5, 1995Date of Patent: November 5, 1996Assignee: Board of Trustees operating Michigan State UniversityInventors: Li-Xia Li, Patrick J. Oriel, Eric A. Grulke
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Patent number: 5571887Abstract: A new thermoplastic homopolymer of o-cresol which is a poly(2-methylphenylene oxide) having a high molecular weight distribution is described. The polymer is prepared using a 2 and/or 6 substituted pyridine catalyst to the molecular weight distribution. The homopolymer can be blended with other thermoplastic polymers. The homopolymer is rapidly biodegraded, particularly in soil containing soil microorganisms.Type: GrantFiled: June 19, 1995Date of Patent: November 5, 1996Assignee: Board of Trustees operating Michigan State UniversityInventors: Li-Xia Li, Patrick J. Oriel, Eric A. Grulke
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Patent number: 5487988Abstract: A process for the preparation of monoterpene compounds (such as perillyl alcohol, aldehyde and .alpha.-terpineol) from limonene is described. The process uses Bacillus stearothermophilus which is effective at high temperatures (55.degree. to 70.degree. C.). A preferred strain of Bacillus stearothermophilus is ATCC 55596.Type: GrantFiled: August 15, 1994Date of Patent: January 30, 1996Assignee: Board of Trustees Operating Michigan State UniversityInventors: Hae C. Chang, Patrick J. Oriel
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Patent number: 4894337Abstract: A process for producing useful quantities of a cyclic hydroxide, such as pyrocatechol from a compound having a benzene ring, such as phenol using a Bacillus is described. The process uses tetracycline to inhibit the modification of the cyclic hydroxide by the Bacillus. Pyrocatechol and other related compounds are commercially useful chemicals.Type: GrantFiled: January 17, 1989Date of Patent: January 16, 1990Assignee: Board of Trustees operating Michigan State UniversityInventors: Patrick J. Oriel, Gopalakrishnan Gurujeyalakshmi
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Patent number: 4806636Abstract: A novel heteropolysaccharide produced by strains of Enterobacter sakazakii, such as Enterobacter sakazakii ATCC 53017, Enterobacter sakazakii ATCC 29004, and Enterobacter sakazakii ATCC 12868, is disclosed. The heteropolysaccharide comprises from about 13 to about 22 percent by weight of L-fucose, from about 19 to about 24 percent by weight of D-galactose, from about 23 to about 30 percent by weight of D-glucose, from about 0 to about 8 percent by weight of D-mannose, from about 29 to about 32 percent by weight of glucuronic acid, said percent ranges based on total carbohydrate; the heteropolysaccharide further comprising about 1 to about 1.5 equivalents of ester per equivalent of neutral sugar. The heteropolysaccharide has many uses as a suspending, thickening, or stabilizing agent, and is particularly useful as a frictional drag reduction agent in aqueous systems.Type: GrantFiled: March 20, 1985Date of Patent: February 21, 1989Assignee: The Dow Chemical CompanyInventors: L. Scott Harris, Patrick J. Oriel
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Patent number: 4402877Abstract: The use of basic ion exchange resins to adsorb rifamycin B or rifamycin S from dilute solutions containing rifamycin B or rifamycin S is disclosed. The rifamycin B or rifamycin S may be recovered from the resin by desorption with a suitable desorbing solvent system.Type: GrantFiled: August 9, 1982Date of Patent: September 6, 1983Assignee: The Dow Chemical CompanyInventors: Jo Ann Gilpin, Patrick J. Oriel, Roger A. Briggs
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Patent number: 4308349Abstract: The production of a heat stable glucose isomerase from a microorganism belonging to the genus Ampullariella and a method for using the isomerase to convert glucose to fructose.Type: GrantFiled: March 9, 1978Date of Patent: December 29, 1981Assignee: The Dow Chemical CompanyInventors: Sharonkay E. Foley, Patrick J. Oriel, Carol C. Epstein
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Patent number: 4246350Abstract: Proteins such as enzymes are immobilized on macroporous resins having recurring bis-picolylamine, imino diacetate or hydroxyethyl picolylamine chelating sites. Immobilization is carried out by contacting the resin with a multivalent metal ion selected from the transition metals or rare earth metals and adsorbing the protein to the resin. This immobilization technique permits strongly binding protein to a high surface area resin. The protein can be readily removed from the resin by simply flushing the resin with an appropriate solution.Type: GrantFiled: March 1, 1979Date of Patent: January 20, 1981Assignee: The Dow Chemical CompanyInventors: Deborah E. Hier, Patrick J. Oriel