Patents by Inventor Patrick J. Paddison

Patrick J. Paddison has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20150025017
    Abstract: The present disclosure provides compositions and methods for treating cellular hyperproliferative disorders with a PHF5? inhibitor, such as siRNA, shRNA, antisense oligonucleotides, or pharmaceutical compounds. Exemplary cellular hyperproliferative disorders that can be treated with the PHF5? antagonists of the present disclosure include cancers, such as gliomas, adenocarcinomas, cervical cancer or prostate cancer.
    Type: Application
    Filed: February 28, 2013
    Publication date: January 22, 2015
    Inventors: Christopher G. Hubert, Patrick J. Paddison, James M. Olson, Robert K. Bradley
  • Methods and compositions for RNA interference
    Patent number: 8383599
    Abstract: The present invention provides methods for attenuating gene expression in a cell using gene-targeted double stranded RNA (dsRNA). The dsRNA contains a nucleotide sequence that hybridizes under physiologic conditions of the cell to the nucleotide sequence of at least a portion of the gene to be inhibited (the “target” gene).
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: February 26, 2013
    Assignee: Cold Spring Harbor Laboratory
    Inventors: Gregory J. Hannon, Patrick J. Paddison, Emily Bernstein, Amy Caudy, Douglas S. Conklin, Scott Hammond
  • CELL-BASED RNA INTERFERENCE AND RELATED METHODS AND COMPOSITIONS
    Publication number: 20100186097
    Abstract: The invention provides, among other things, methods for performing RNA interference in stem cells and methods for using the stem cells in vivo.
    Type: Application
    Filed: July 6, 2009
    Publication date: July 22, 2010
    Applicant: Cold Spring Harbor Laboratory
    Inventors: Scott W. LOWE, Michael HEMANN, Gregory J. HANNON, Patrick J. PADDISON, Jack ZILFOU, Jordan FRIDMAN, Michelle A. CARMELL, Ross DICKINS, Thomas A. ROSENQUIST, Stephen J. ELLEDGE
  • Embryonic stem cell self maintenance and renewal reporter
    Patent number: 7662941
    Abstract: The present invention relates to methods and compositions for assaying embryonic stem cell maintenance. In particular, the present invention provides reporter constructs for stem cell pluripotency and differentiation and cells and organisms containing such constructs.
    Type: Grant
    Filed: January 17, 2006
    Date of Patent: February 16, 2010
    Assignee: The Trustees of the University of Princeton - Princeton University
    Inventors: Ihor R. Lemischka, Christoph Schaniel, Feng Li, Xenla Schafer, Patrick J. Paddison
  • Cell-Based Rna Interference and Related Methods and Compositions
    Publication number: 20080226553
    Abstract: This invention provides, among other things, methods for performing RNA interference in stem cells and methods for using stem cells in vivo.
    Type: Application
    Filed: September 29, 2003
    Publication date: September 18, 2008
    Applicant: Cold Spring Harbor Laboratory
    Inventors: Scott W. Lowe, Michelle A. Carmell, Gregory J. Hannon, Patrick J. Paddison, Jack Zilfou, Jordan Fridman, Michelle A. Carmell, Ross Dickins, Thomas A. Rosenquist, Stephen J. Elledge
  • Methods and compositions for RNA interference
    Publication number: 20080213861
    Abstract: The present invention provides methods for attenuating gene expression in a cell, especially in a mammalian cell, using gene-targeted double stranded RNA (dsRNA), such as a hairpin RNA. The dsRNA contains a nucleotide sequence that hybridizes under physiologic conditions of the cell to the nucleotide sequence of at least a portion of the gene to be inhibited (the “target” gene).
    Type: Application
    Filed: August 20, 2007
    Publication date: September 4, 2008
    Inventors: Gregory J. Hannon, Patrick J. Paddison, Despina C. Siolas
  • Methods and compositions for RNA interference
    Publication number: 20040086884
    Abstract: The present invention provides methods for attenuating gene expression in a cell using gene-targeted double stranded RNA (dsRNA). The dsRNA contains a nucleotide sequence that hybridizes under physiologic conditions of the cell to the nucleotide sequence of at least a portion of the gene to be inhibited (the “target” gene).
    Type: Application
    Filed: January 24, 2003
    Publication date: May 6, 2004
    Applicants: Genetica, Inc., Cold Spring Harbor Laboratory
    Inventors: David H. Beach, Emily Bernstein, Amy Caudy, Scott Hammond, Gregory J. Hannon, Patrick J. Paddison, Douglas Conklin