Patents by Inventor Patrick J. Sheeran

Patrick J. Sheeran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Efficient process for the preparation of [S-(R,S)]-N-[1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2[4-[4-methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-1-azetidine carboxamide, a human leukocyte elastase inhibitor
    Patent number: 6194569
    Abstract: Processes for the preparation of [S-(R,S)]-N-[1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2[4-[4-methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-l-azetidine carboxamide, a useful inhibitor of human leukocyte elastase (HLE), are described. The process including (a) contacting a compound of formula (II): with a compound of formula (III): in a first polar solvent system in the presence of an aqueous base and a phase transfer catalyst, to form the title compound, or a salt form thereof.
    Type: Grant
    Filed: August 30, 1999
    Date of Patent: February 27, 2001
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Patrick J. Sheeran, Luigi Anzalone, Hui-Yin Li, Joseph M. Fortunak, Louis Storace
  • Process for preparing dialkyl propanediimidate dihydrohalides
    Patent number: 4495108
    Abstract: An improved process for preparing a dialkyl propanediimidate dihydrohalide by reacting malononitrile, an alcohol, and hydrogen halide, wherein the improvement comprises conducting the reaction under greater than atmospheric pressure in a halobenzene, haloalkylbenzene or alkylbenzene solvent.
    Type: Grant
    Filed: March 11, 1983
    Date of Patent: January 22, 1985
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Jeffrey S. Gramm, Edwin L. Mongan, Jr., Patrick J. Sheeran