Patents by Inventor Patrick J. Sinko
Patrick J. Sinko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130302249Abstract: Peptide ligands for transporting therapeutic agents across the intestinal epithelial barrier that ordinarily are inadequately absorbed and must be delivered by alternative means, which contain an isolated amino acid sequence wherein at least one pair of amino acids are of an opposite charge and the pair members are separated by a spacer of 1-12 amino acid residues including at least one hydrophobic amino acid, and wherein the length of the amino acid sequence is greater than 5 and less than 20 amino acids. Pharmaceutical compositions for gastro-intestinal delivery and methods for the gastrointestinal delivery of poorly absorbed therapeutic agents are also disclosed.Type: ApplicationFiled: October 14, 2011Publication date: November 14, 2013Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Patrick J. Sinko, Xiaoping Zhang, Zoltan Szekely
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Publication number: 20130072447Abstract: The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of which is covalently bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at least one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent.Type: ApplicationFiled: May 14, 2012Publication date: March 21, 2013Applicant: Rutgers, The State University of New JerseyInventors: Srinivasan Ramanathan, Stanley Stein, Michael Leibowitz, Patrick J. Sinko, Tamara Minko, Gregory C. Williams, Goubao Zhang, Xiaoping Zhang, Shahrair Pooyan, Seong Hee Park, Bo Qiu, Pankaj Paranjpe
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Publication number: 20120183578Abstract: The instant invention relates to polyethylene glycol-based dendrons, otherwise known as PEGtide dendrons, compositions thereof and methods of use.Type: ApplicationFiled: November 14, 2011Publication date: July 19, 2012Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Patrick J. Sinko, Jieming Gao, Yashveer Singh, Xiaoping Zhang, Matthew S. Palombo, Stanley Stein
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SYNERGISTIC COMBINATIONS TO REDUCE PARTICLE DOSE FOR TARGETED TREATMENT OF CANCER AND ITS METASTASES
Publication number: 20120183621Abstract: Non-Small Cell Lung Carcinomas (NSCLCs) are treated with Gel Micro-Particles (GMPs) that passively accumulate in the lungs and contain Nano-Particles (NPs) combining one or more therapeutic agents that are cytotoxic to the NSCLC with one or more NSCLC active targeting ligands, as well as one or more other optional agents that increase cellular uptake, enhance the pro-apoptotic effect of the chemotherapeutic agent(s), and the like. NPs targeting other cancer cells are also disclosed, as well as NP-containing GMPs that reduce the occurrence of tumor metastasis.Type: ApplicationFiled: November 14, 2011Publication date: July 19, 2012Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Patrick J. Sinko, Jieming Gao, Manjeet Deshmukh, Xiaoping Zhang, Matthew S. Palombo, Sherif Ibrahim -
Publication number: 20120093723Abstract: This invention provides multimeric nanocarrier for in vivo delivery of a bioactive agent, comprising at least two peptide monomers reversibly or irreversibly linked with one or more of said bioactive agents, wherein said two or more of said peptide monomers are covalently linked by a biodegradable difunctional moiety, as well as methods of using this nanocarrier.Type: ApplicationFiled: March 16, 2010Publication date: April 19, 2012Applicant: Rutgers, The State University of New JerseyInventors: Patrick J. Sinko, Stanley Stein, Simi Gunaseelan, Shahrair Pooyan, Matthew S. Palombo, Xiaoping Zhang
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Patent number: 8124051Abstract: The present invention relates to compositions and methods for producing a complex drug delivery system which specifically targets cancer cells, has an increase in cellular uptake, is cytotoxic, and suppresses antiapoptotic cellular defenses.Type: GrantFiled: June 27, 2008Date of Patent: February 28, 2012Assignee: Rutgers, The State University of New JerseyInventors: Tamara Minko, Patrick J. Sinko, Stanley Stein
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Publication number: 20110286926Abstract: This invention concerns an in situ biodegradable hydrogel drug delivery system in which the components are assembled in a manner that provides a mechanism for the timed cleavage of a particular amide bond in a covalently linked active agent or of the hydrogel structure.Type: ApplicationFiled: November 20, 2009Publication date: November 24, 2011Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Patrick J. Sinko, Manjeet Deshmukh, Yashveer Singh, Simi Gunaseelan
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Publication number: 20110268803Abstract: The American Cancer Society estimated that in 2009, 1,479,350 new cancer cases would be diagnosed in the United States of which 219,440 would be lung and bronchus related. The standard treatments for NSCLC include surgery, chemotherapy, radiation, laser and photodynamic therapy, all with various success rates depending on the stage of the cancer. National Cancer Institute assesses, however, that results of standard treatment are generally poor with only a 15 percent 5-year survival rate for combined cancer stages. Challenges facing the current chemotherapy drugs include excessive toxicity to healthy tissues and limited ability to prevent metastases. A dual drug delivery system described herein selectively targets the lung to deliver anti-cancer drugs and inhibit the formation of metastases.Type: ApplicationFiled: April 5, 2011Publication date: November 3, 2011Applicants: Rutgers, The State University of New Jersey, THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Robert K. Prud'homme, Patrick J. Sinko, Howard A. Stone, Nathalie M. Pinkerton, Lei Shi, Jiandi Wan, Sherif Ibrahim, Dayuan Gao
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Publication number: 20110135732Abstract: The present invention is directed to pharmaceutical compositions, and method for preparing pharmaceutical compositions, comprising a cross-linked matrix physically entrapping at least one therapeutic agent. The matrix may comprise one or more phases in addition to an aqueous phase, such as a solid and/or oil phase. The matrix of the invention has at least one controlled release in-vivo kinetic profile, and may have additional profiles for the same agent. The matrix may also comprise more than one therapeutic agent, and each additional therapeutic agent may have one or more controlled release in-vivo kinetic profile.Type: ApplicationFiled: November 22, 2010Publication date: June 9, 2011Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Stanley Stein, Bo Qiu, Patrick J. Sinko
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Publication number: 20110117024Abstract: Novel classes of multi-arm polyalkylene oxide-based materials including PEG nanocarriers, nanogel particles, and aggregated nanogel particles are disclosed. These classes of compositions may be associated with therapeutic agents and targeting moieties, or visibility enhancing agents, and may have a modified surface structure. In some embodiments the PEG-based materials can be made to provide relatively high drug loads with improved solubility and targeted delivery.Type: ApplicationFiled: April 6, 2009Publication date: May 19, 2011Applicant: RUTGERS THE STATE UNIVERSITY OF NEW JERSEYInventors: Patrick J. Sinko, Stanley Stein, Hilliard Kutscher, Manjeet Deshmukh, Anupa Menjoge, Yashveer Singh, Simi Gunaseelan
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Publication number: 20110087004Abstract: The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of which is covalently bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at least one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent.Type: ApplicationFiled: June 18, 2010Publication date: April 14, 2011Inventors: Srinivasan Ramanathan, Stanley Stein, Michael Leibowitz, Patrick J. Sinko, Tamara Minko, Gregory C. Williams, Goubao Zhang, Xiaoping Zhang, Shahrair Pooyan, Seong Hee Park, Bo Qiu, Pankaj Paranjpe
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Publication number: 20110033503Abstract: Described is a spray-on hydrogel comprising water-soluble PEG polymers that cross-link in situ to form a hydrogel such that the cross-links are reversible. The hydrogel can be useful as a drug delivery composition, wound dressing or surgery adjuvant. Polyethylene glycol polymer and cross-linker solutions are sprayed simultaneously through a common orifice. Cross-linking via formation of thioether or disulfide bonds is initiated upon mixing, providing rapid gelation. The hydrogel components can be derivatized with RGD peptides or analogs thereof to promote retention in/on a body compartment such as the skin, surface of the eye, or a mucosa such as the vaginal mucosa. The cross-links are reversed using a reducing solution enabling easy removal of the hydrogel by dissolution. Processes for preparation of the cross-linker, RGD derivatized PEG and RGD-linked agents are also disclosed.Type: ApplicationFiled: April 23, 2008Publication date: February 10, 2011Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Patrick J. Sinko, Stanley Stein, Anupa R. Menjoge, Simi Gunaseelan, Siva Naga Sree priay Anumolu, Raghavandra Navath
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Patent number: 7846893Abstract: Monodisperse macromolecular conjugate compositions of a peptidic carrier irreversibly or reversibly conjugated with one or more effectors and one or more therapeutic agents, wherein at least one effector or therapeutic agent is attached to a pendant reactive group on said peptidic carrier via a water-soluble polymer. Monodispersity is obtained through the use of orthogonal and separate conjugation reactions.Type: GrantFiled: February 16, 2006Date of Patent: December 7, 2010Assignee: Rutgers, The State University of New JerseyInventors: Patrick J. Sinko, Stanley Stein, Simi Gunaseelan, Shahriar Pooyan, Li Wan, Xiaoping Zhang
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Patent number: 7740882Abstract: The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of which is covalently bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at least one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent.Type: GrantFiled: June 29, 2005Date of Patent: June 22, 2010Inventors: Srinivasan Ramanathan, Stanley Stein, Michael Leibowitz, Patrick J. Sinko, Tamara Minko, Gregory C. Williams, Goubao Zhang, Xiaoping Zhang, Shahrair Pooyan, Seong Hee Park, Bo Qiu, Pankaj Paranjpe
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Publication number: 20090104254Abstract: Formulations and methods for their preparation including a hydrogel including a crosslinked matrix comprising a polymer, and a one or more liposomes containing a therapeutic agent.Type: ApplicationFiled: December 22, 2005Publication date: April 23, 2009Applicant: Rutgers, The State University of New JerseyInventors: Patrick J. Sinko, Stanley Stein, Anita Lalloo
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Publication number: 20080280813Abstract: The present invention relates to compositions and methods for producing a complex drug delivery system which specifically targets cancer cells, has an increase in cellular uptake, is cytotoxic, and suppresses antiapoptotic cellular defenses.Type: ApplicationFiled: June 27, 2008Publication date: November 13, 2008Applicant: Rutgers, The State University of New JerseyInventors: Tamara MINKO, Patrick J. Sinko, Stanley Stein
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Publication number: 20080188399Abstract: Monodisperse macromolecular conjugate compositions of a peptidic carrier irreversibly or reversibly conjugated with one or more effectors and one or more therapeutic agents, wherein at least one effector or therapeutic agent is attached to a pendant reactive group on said peptidic carrier via a water-soluble polymer. Monodispersity is obtained through the use of orthogonal and separate conjugation reactions.Type: ApplicationFiled: February 16, 2006Publication date: August 7, 2008Applicant: Ruthers, The State University of New JerseyInventors: Patrick J. Sinko, Stanley Stein, Simi Gunaseelan, Shahriar Pooyan, Li Wan, Xiaoping Zhang
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Patent number: 6996473Abstract: A secondary compound library produced by a method of screening a compound library or portion thereof by absorption is provided. The method includes a step (i) that screens a primary compound library or portion thereof having a plurality of test samples containing isolated compounds or isolated mixtures of compounds per test sample by generating an in vivo absorption profile for each of the test samples from initial dose data and from in vitro bioavailability data comprising permeability and solubility data for each of the test samples, wherein the absorption profile includes at least one of rate of absorption, extent of absorption, and concentration of a test sample. Step (ii) produces a secondary compound library that includes at least one compound from the primary compound library having a desired absorption profile.Type: GrantFiled: November 21, 2001Date of Patent: February 7, 2006Assignee: Lion Bioscience AGInventors: George M. Grass, Glen D. Leesman, Daniel A. Norris, Patrick J. Sinko, John E. Wehrli
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Publication number: 20040180322Abstract: Permeability models and methods for creating the models are disclosed. The models include receiving as an input in vitro permeability and structure data for a particular compound. Then the data is mapped to at least one permeability. In some models the data is mapped to a plurality of permeabilities, each associated with a specific region in a mammalian GI tract. Some models may take into consideration solubility, permeability and at least one molecular descriptor associated with the compound of interest.Type: ApplicationFiled: June 5, 2003Publication date: September 16, 2004Inventors: George M. Grass, Glen D. Leesman, Daniel A. Norris, Patrick J. Sinko, Jehangir Athwal, Carleton Sage, Troy Bremer, Kevin Holme, Yong-Hee Lee, Kyoung Lee
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Publication number: 20040039530Abstract: A system for simulating metabolism of a compound in a mammal is disclosed that includes a metabolism simulation model of a mammalian liver. This model has equations which, when executed on a computer, calculate the rate of metabolism of the compound in the cells of the mammalian liver and a rate of transport of the compound into the cells, wherein the simulation model determines an amount of the metabolism product. The rate of metabolism may be a rate of depletion of the compound. The metabolism product may be an amount of the compound remaining after the compound's first passage through the mammalian liver (This is not necessarily limited to first pass, nor would it need to be limited to the liver. Intestinal metabolism could also be modeled). The rate of metabolism may alternatively be a rate of accumulation of a metabolite of the compound.Type: ApplicationFiled: May 30, 2003Publication date: February 26, 2004Inventors: Glen D Leesman, Daniel A Norris, Patrick J Sinko, Kevin Holme, Tatyana Izhikevich, Julie Doerr-Stevens, Edward Lecluyse, Dhiren R Thakker, George M Grass