Abstract: The present invention relates generally to proteasome inhibiting ?-lactam compounds useful for the treatment of cancer and neurodegenerative disorders. The invention also provides pharmaceutical compositions and extended release formulations of said compounds, and medical uses of said compounds and/or pharmaceutical compositions to treat cancer and neurodegenerative disorders.

Abstract: The present invention relates generally to proteasome inhibiting ?-lactam compounds useful for the treatment of cancer and neurodegenerative disorders. The invention also provides pharmaceutical compositions and extended release formulations of said compounds, and medical uses of said compounds and/or pharmaceutical compositions to treat cancer and neurodegenerative disorders.

Abstract: Methods for the secure control of an apparatus by way of a system include a viewing device comprising a touch surface, a viewing screen and a processing and control unit. The secure control method comprises the following steps: displaying a first symbol corresponding to a first state of the apparatus and a second symbol corresponding to a second state; implementing the second state of the apparatus by way of a single continuous press on the touch surface starting on the first symbol, passing through a first crossing point, following a pattern comprising a part passing diagonally through a plurality of rows and columns of the matrix, passing through a second crossing point and finishing on the second symbol.

Abstract: Methods for the secure control of an apparatus by way of a system include a viewing device comprising a touch surface, a viewing screen and a processing and control unit. The secure control method comprises the following steps: displaying a first symbol corresponding to a first state of the apparatus and a second symbol corresponding to a second state; implementing the second state of the apparatus by way of a single continuous press on the touch surface starting on the first symbol, passing through a first crossing point, following a pattern comprising a part passing diagonally through a plurality of rows and columns of the matrix, passing through a second crossing point and finishing on the second symbol.

Abstract: The device according to the invention, which makes it possible to secure a client application, including an acquisition and processing module of measured properties (GM) to generate properties of interest (GI); a lookup table associating each dynamic variable (VD) of each of the graphic objects to be maintained with a property of interest (GI); and a module for generating commands capable of issuing a command (C) to the server application. The device includes dedicated means for securing the operation of said acquisition and processing module; dedicated means for securing said lookup table; and dedicated means for securing said command generating module.

Abstract: The present invention relates to compound of general formula (1) wherein R1 represents C6-C10 aryl comprising one or two fused rings, wherein from 2 to 5 carbon atoms may be replaced with a heteroatom selected from O, S and NR6, and eventually substituted with from 5 to 11 substituents selected from R6, halo, CN, NO2, CF3, OCF3, COOR6, OCOR6, SO2NR6R7, CONR6R7, NR6R7, NR6COR7, (CH2)p—NR6R7, (CH2)p—OR6 and (CH2)pSR6, as well as, if appropriate, their pharmaceutically acceptable salts and/or isomers, tautomers, solvates or isotopic variations thereof. The compounds are useful for the treatment of cancers.

Abstract: The present invention relates to compound of general formula (1) wherein R1 represents C6-C10 aryl comprising one or two fused rings, wherein from 2 to 5 carbon atoms may be replaced with a heteroatom selected from O, S and NR6, and eventually substituted with from 5 to 11 substituents selected from R6, halo, CN, NO2, CF3, OCF3, COOR6, OCOR6, SO2NR6R7, CONR6R7, NR6R7, NR6COR7, (CH2)p—NR6R7, (CH2)p—OR6 and (CH2)pSR6, as well as, if appropriate, their pharmaceutically acceptable salts and/or isomers, tautomers, solvates or isotopic variations thereof. The compounds are useful for the treatment of cancers.

Abstract: The device according to the invention, which makes it possible to secure a client application, including an acquisition and processing module of measured properties (GM) to generate properties of interest (GI); a lookup table associating each dynamic variable (VD) of each of the graphic objects to be maintained with a property of interest (GI); and a module for generating commands capable of issuing a command (C) to the server application. The device includes dedicated means for securing the operation of said acquisition and processing module; dedicated means for securing said lookup table; and dedicated means for securing said command generating module.

Abstract: This assembly between a spigot and a socket comprises a sealing gasket provided with a locking insert which comprises a head and a foot. The head comprises a radial projection, designed to press against a bottom surface of an anchoring groove belonging to the socket and a first inclined projection, designed to press against an inclined surface of the anchoring groove. The head also comprises a frontal projection which is offset from the first inclined projection and designed to press against an annular frontal surface of the anchoring groove. Application to the connecting of cast iron pipes.