Abstract: A system for redistributing traffic in response to failure of a service region. An event bus service is configured to monitor performance of computing resources in a first region of the plurality of regions, wherein events are received from one or more event sources at the event bus via a network endpoint created for the event bus and delivered to one or more event targets by the event bus service in the primary region. Based on the monitoring of the performance of the computing resources in the first region, the event bus service detects a region change event for the event bus in the first region, after detection of the region change event, redirects further events to the event bus in the secondary region, wherein the further events are delivered to the one or more event targets by the event bus service in the secondary region.

Abstract: The present invention relates to tools and methods for the generation of antibodies which specifically bind chemokine receptors, such as CC or CXC chemokine receptors. Provided are isolated sulfated polypeptides and conjugates thereof, which can be used for example as antigens or for off target panning to facilitate the generation of anti-human, anti-cynomolgus, and/or anti-mouse chemokine receptor antibodies, e.g. for the generation of antibodies with fully human CDRs and/or other favorable properties for therapeutic use. The present invention furthermore relates to antibodies and conjugates thereof which can be obtained by applying the aforementioned tools and methods. Provided are antibodies specifically binding to human, cynomolgus and/or murine CCR8 with favorable properties for therapeutic use, such as cross-reactive antibodies, fully human antibodies, low internalizing (including non-internalizing) antibodies, and antibodies efficiently inducing ADCC and/or ADCP in Treg cells.

Abstract: The invention relates to a rotational linear motor drive system for the acceleration of a rotational shaft. The rotational linear motor drive system comprises a stator, with at least two stator elements, arranged on either side of a non-magnetic conductive rotor. Each stator maybe connected to its own energy source or may be connected in series to a single energy source. The rotor can operate at the same time with the two synchronized stator groups, or the rotor may be driven out of phase by each stator group. No permanent magnets are used in the design of the motor.

Abstract: The present invention relates to tools and methods for the generation of antibodies which specifically bind chemokine receptors, such as CC or CXC chemokine receptors. Provided are isolated sulfated polypeptides and conjugates thereof, which can be used for example as antigens or for off target panning to facilitate the generation of anti-human, anti-cynomolgus, and/or anti-mouse chemokine receptor antibodies, e.g. for the generation of antibodies with fully human CDRs and/or other favorable properties for therapeutic use. The present invention furthermore relates to antibodies and conjugates thereof which can be obtained by applying the aforementioned tools and methods. Provided are antibodies specifically binding to human, cynomolgus and/or murine CCR8 with favorable properties for therapeutic use, such as cross-reactive antibodies, fully human antibodies, low internalizing (including non-internalizing) antibodies, and antibodies efficiently inducing ADCC and/or ADCP in Treg cells.

Abstract: A system is configured to replicate events to be processed by service regions. The system implements an event bus service that hosts an event bus in respective ones of a plurality of regions. The event bus service is configured to receive, at the event bus in a secondary region of the plurality of regions, a replicated indication of an event that is replicated from the event bus in a primary region of the plurality of regions. The event bus service determines, at the event bus in the secondary region, whether the primary region has completed processing of the event. Based on a determination that the primary region has not completed processing of the event within the pre-determined time period, the event bus service processes the event according to the replicated indication and indicates, in the replication record, that the secondary region has completed processing of the event.

Abstract: Methods and systems building tiered request-response communications using probability-based selections. For example, the methods and systems may use machine learning and/or artificial intelligence to generate a tier of a tiered request-response communications with a subset of user input fields and/or tiers, in which the subset is dispositive for completing the tiered request-response communication.

Abstract: The present invention relates to tools and methods for the generation of antibodies which specifically bind chemokine receptors, such as CC or CXC chemokine receptors. Provided are isolated sulfated polypeptides and conjugates thereof, which can be used for example as antigens or for off target panning to facilitate the generation of anti-human, anti-cynomolgus, and/or anti-mouse chemokine receptor antibodies, e.g. for the generation of antibodies with fully human CDRs and/or other favorable properties for therapeutic use. The present invention furthermore relates to antibodies and conjugates thereof which can be obtained by applying the aforementioned tools and methods. Provided are antibodies specifically binding to human, cynomolgus and/or murine CCR8 with favorable properties for therapeutic use, such as cross-reactive antibodies, fully human antibodies, low internalizing (including non-internalizing) antibodies, and antibodies efficiently inducing ADCC and/or ADCP in Treg cells.

Abstract: The present invention relates to a manufacturing process and intermediates for preparing a crystalline or non-crystalline form of N-((1S,3S)-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclobutyl)propane-1-sulfonamide. The present invention also relates to salt forms and pharmaceutical compositions comprising the crystalline form, and to methods for use of the compound prepared from a crystalline form in the treatment of various diseases.

Abstract: Techniques are described for enabling a cloud-based service to provide rate controls for events to be delivered by the service to event targets. An event bus service, for example, broadly enables users to create and configure event buses that receive events from event sources and from which the event bus service filters, transforms, routes, and delivers events to selected event targets according to configurable rules. A new event egress call pattern is provided that estimates a rate of attempted event traffic to event targets and a rate of successfully delivered event traffic (also referred to as a local rate estimation), and that uses the rate estimations to determine when it may be appropriate to throttle event delivery, thereby reducing stress on downstream systems experiencing capacity issues and potentially reducing a number of event delivery retries to be handled by the event bus service.

Abstract: A system is configured to simulate outages of network resources. The system is configured to provide a control plane for computing resources of a provider network. The control plane is configured to cause simulated outages of a primary region of the plurality of regions selected to host the plurality of different computing resources. During the simulated outages, the control plane moves respective workloads of the plurality of different computing resources to be performed in the one or more secondary networks and tracks a performance of the one or more secondary regions hosting the moved respective workloads of the plurality of computing resources. After completing individual ones of the simulated outages of the first network, the control plane moves the respective workloads of the plurality of different computing resources back to the primary region.

Abstract: A vertical internal coating machine is taught, which may be used with bodies such as cans (2 piece, 3 piece, draw, redraw) and including cylinders, containers and any similar body. In the machine cans or similar bodies are sprayed with the star wheel in continuous motion without stopping and starting. The machine teaches that a plurality of spray guns may be provided for each pocket of the star wheel. By means of the machine an improved line layout is devised which may eliminate the need to raise the bodies immediately prior to a necker by allowing the vertical can internal coating machine and internal bake oven to be disposed on any level of the facility, upper, lower, mezzanine, etc. In green aspects, the machine may use negative pressure cabinets/hoods and positive pressure tunnels to entrain volatile organic chemicals emitted by the spray guns and coated bodies and may send these VOCs to a VOC destruction device, such as an oven.

Abstract: Disclosed is a system and method of providing enhanced content to a PSAP or other service center whereby when a 911 call is to be initiated, prior to the call or text communication being sent, the software application on the device contacts the cloud-based dynamic page service. The cloud-based dynamic page service receives event information, dynamically creates a page for the event along with a page identifier, and sends the page identifier to the software application of the initiating device. Then, the software application on the device initiates a 911 communication and includes the page identifier with the communication. In some cases, the page identifier may be sent as a separate communication.

Abstract: The present invention relates to tools and methods for the generation of antibodies which specifically bind chemokine receptors, such as CC or CXC chemokine receptors. Provided are isolated sulfated polypeptides and conjugates thereof, which can be used for example as antigens or for off target panning to facilitate the generation of anti-human, anti-cynomolgus, and/or anti-mouse chemokine receptor antibodies, e.g. for the generation of antibodies with fully human CDRs and/or other favorable properties for therapeutic use. The present invention furthermore relates to antibodies and conjugates thereof which can be obtained by applying the aforementioned tools and methods. Provided are antibodies specifically binding to human, cynomolgus and/or murine CCR8 with favorable properties for therapeutic use, such as cross-reactive antibodies, fully human antibodies, low internalizing (including non-internalizing) antibodies, and antibodies efficiently inducing ADCC and/or ADCP in Treg cells.

Abstract: A probabilistic data structure such as a bloom filter may be used to provide a space efficient representation of rules that define events of interest to sources and may be used to reduce the number of events ingested by an event bus system. An event bus system may generate a probabilistic data structure based on the rules that may be used at the event source as a filter. The probabilistic data structure predetermines whether the events to be sent to the event bus system will be of interest to any event targets and if an event is of no interest to any of the event targets, the event will not be sent.

Abstract: A method of producing a semiconductor module arrangement includes providing a first subassembly having a number N1 of first adjustment openings, a second subassembly having a number N2 of second adjustment openings and a third subassembly having a plurality of adjustment pins which are fixedly connected to one another, the first subassembly, the second subassembly and the third subassembly being independent of one another and not connected to one another. The first subassembly, the second subassembly and the third subassembly are arranged relative to one another in such a way that each of the adjustment pins engages into one of the first adjustment openings and/or into one of the second adjustment openings.

Abstract: A wireless earring assembly for discretely streaming audio into a user's ears includes a pair of earrings that each includes an ornament, a stud extending away from the ornament and a retainer that is slidable onto the stud. A pair of audio units is each integrated into the ornament of a respective one of the earrings. Each of the audio units is in wireless communication with an audio source such that each of the audio units receives an audio signal from the audio source. Additionally, each of the audio units has sound emitting capabilities to emit audible sounds from the audio signal toward the user's ear.

Abstract: The present invention relates to a manufacturing process and intermediates for preparing a crystalline or non-crystalline form of N-((1S,3S)-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclobutyl)propane-1-sulfonamide. The present invention also relates to salt forms and pharmaceutical compositions comprising the crystalline form, and to methods for use of the compound prepared from a crystalline form in the treatment of various diseases.

Abstract: Disclosed is a system and method of providing enhanced content to a PSAP or other service center whereby when a 911 call is to be initiated, prior to the call or text communication being sent, the software application on the device contacts the cloud-based dynamic page service. The cloud-based dynamic page service receives event information, dynamically creates a page for the event along with a page identifier, and sends the page identifier to the software application of the initiating device. Then, the software application on the device initiates a 911 communication and includes the page identifier with the communication. In some cases, the page identifier may be sent as a separate communication.

Abstract: Disclosed is a system and method of automatically generating an event-based request communication (“ERC”) and routing the ERC to a public safety answering point (“PSAP”) (or other call center) to service the ERC based on PSAP profiles that each specify capabilities of a given PSAP. A client device may be programmed to obtain the capabilities of a relevant PSAP, and generate and communicate an ERC based on the capabilities of the PSAP. The ERC may be generated in a format that the relevant PSAP is capable of processing. The format may include a voice call, a text message, an electronic mail message, a shortwave radio communication, and/or other type of broadband wireless or wireline communication.

Abstract: The present invention relates to a manufacturing process and intermediates for preparing a crystalline or non-crystalline form of N-((1S,3S)-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclobutyl)propane-1-sulfonamide. The present invention also relates to salt forms and pharmaceutical compositions comprising the crystalline form, and to methods for use of the compound prepared from a crystalline form in the treatment of various diseases.