Abstract: An exercise bike includes a frame, a rotor assembly and a drive assembly mounted on the frame, where the drive assembly is configured to drive rotation of the rotor assembly, and a cover configured to at least partially cover the rotor assembly. The components of the drive assembly and the rotor assembly include structures that improve the performance of the exercise bike, including but not limited to a strong and rigid construction and improvements in belt tracking, user feel, effort consistency, synchronization, and rotor performance.

Abstract: Support systems for handpieces are provided. The support system includes a boom assembly having a rigid anchor base and a flexible rod having proximal and distal ends, and a connection assembly having a proximal end configured to couple to the distal end of the flexible rod and a distal end configured to couple to the handpiece. The flexible rod is pivotally secured at the proximal end thereof to the anchor base, and the flexible rod has a flexibility that increases from a distal end to the proximal end thereof. The connection assembly is configured to enable the handpiece to rotate in at least two degrees of freedom. The boom assembly is configured to support the connection assembly and the handpiece such that the connection assembly and the handpiece rest in a neutral position.

Abstract: The present invention relates to a process for producing a beer bittering agent via enzyme catalyzed bioconversion of hop-derived isoalpha acids to dihydro-(rho)-isoalpha acids.

Abstract: A system for redistributing traffic in response to failure of a service region. An event bus service is configured to monitor performance of computing resources in a first region of the plurality of regions, wherein events are received from one or more event sources at the event bus via a network endpoint created for the event bus and delivered to one or more event targets by the event bus service in the primary region. Based on the monitoring of the performance of the computing resources in the first region, the event bus service detects a region change event for the event bus in the first region, after detection of the region change event, redirects further events to the event bus in the secondary region, wherein the further events are delivered to the one or more event targets by the event bus service in the secondary region.

Abstract: The present invention relates to tools and methods for the generation of antibodies which specifically bind chemokine receptors, such as CC or CXC chemokine receptors. Provided are isolated sulfated polypeptides and conjugates thereof, which can be used for example as antigens or for off target panning to facilitate the generation of anti-human, anti-cynomolgus, and/or anti-mouse chemokine receptor antibodies, e.g. for the generation of antibodies with fully human CDRs and/or other favorable properties for therapeutic use. The present invention furthermore relates to antibodies and conjugates thereof which can be obtained by applying the aforementioned tools and methods. Provided are antibodies specifically binding to human, cynomolgus and/or murine CCR8 with favorable properties for therapeutic use, such as cross-reactive antibodies, fully human antibodies, low internalizing (including non-internalizing) antibodies, and antibodies efficiently inducing ADCC and/or ADCP in Treg cells.

Abstract: The invention relates to a rotational linear motor drive system for the acceleration of a rotational shaft. The rotational linear motor drive system comprises a stator, with at least two stator elements, arranged on either side of a non-magnetic conductive rotor. Each stator maybe connected to its own energy source or may be connected in series to a single energy source. The rotor can operate at the same time with the two synchronized stator groups, or the rotor may be driven out of phase by each stator group. No permanent magnets are used in the design of the motor.

Abstract: The present disclosure relates generally to a water-resistant gypsum board including a gypsum core with a first major surface and a second, opposing major surface; a first liner having a first major surface and a second, opposing major surface, the first liner comprising at at least the first major surface thereof a condensation product of a polysiloxane comprising at least one silanol, the first major surface of the first liner being disposed against the first major surface of the gypsum core; and a second liner having a first major surface and a second, opposing major surface, the first major surface of the second liner being disposed against the second major surface of the gypsum core.

Abstract: The present invention relates to tools and methods for the generation of antibodies which specifically bind chemokine receptors, such as CC or CXC chemokine receptors. Provided are isolated sulfated polypeptides and conjugates thereof, which can be used for example as antigens or for off target panning to facilitate the generation of anti-human, anti-cynomolgus, and/or anti-mouse chemokine receptor antibodies, e.g. for the generation of antibodies with fully human CDRs and/or other favorable properties for therapeutic use. The present invention furthermore relates to antibodies and conjugates thereof which can be obtained by applying the aforementioned tools and methods. Provided are antibodies specifically binding to human, cynomolgus and/or murine CCR8 with favorable properties for therapeutic use, such as cross-reactive antibodies, fully human antibodies, low internalizing (including non-internalizing) antibodies, and antibodies efficiently inducing ADCC and/or ADCP in Treg cells.

Abstract: An exercise bike includes a frame, a pedal assembly, and a rotor mounted on the frame and operably connected to the pedal assembly. The rotor includes a hub with a plurality of blades extending radially outward from the hub. A rotor cover is mounted on the frame and at least partially encloses the rotor, and has opposed side portions and a middle portion extending between the side portions. One side portion has an opening, and the rotor cover further has slots extending on opposite sides of the middle portion. The bike also includes a moveable baffle that is moveable to selectively restrict air passage through the opening, and an actuator connected to the moveable baffle and including a handle and two legs extending into the slots. The actuator is moveable by the legs traveling along the slots to adjust the moveable baffle.

Abstract: A system is configured to replicate events to be processed by service regions. The system implements an event bus service that hosts an event bus in respective ones of a plurality of regions. The event bus service is configured to receive, at the event bus in a secondary region of the plurality of regions, a replicated indication of an event that is replicated from the event bus in a primary region of the plurality of regions. The event bus service determines, at the event bus in the secondary region, whether the primary region has completed processing of the event. Based on a determination that the primary region has not completed processing of the event within the pre-determined time period, the event bus service processes the event according to the replicated indication and indicates, in the replication record, that the secondary region has completed processing of the event.

Abstract: Methods and systems building tiered request-response communications using probability-based selections. For example, the methods and systems may use machine learning and/or artificial intelligence to generate a tier of a tiered request-response communications with a subset of user input fields and/or tiers, in which the subset is dispositive for completing the tiered request-response communication.

Abstract: The present invention relates to tools and methods for the generation of antibodies which specifically bind chemokine receptors, such as CC or CXC chemokine receptors. Provided are isolated sulfated polypeptides and conjugates thereof, which can be used for example as antigens or for off target panning to facilitate the generation of anti-human, anti-cynomolgus, and/or anti-mouse chemokine receptor antibodies, e.g. for the generation of antibodies with fully human CDRs and/or other favorable properties for therapeutic use. The present invention furthermore relates to antibodies and conjugates thereof which can be obtained by applying the aforementioned tools and methods. Provided are antibodies specifically binding to human, cynomolgus and/or murine CCR8 with favorable properties for therapeutic use, such as cross-reactive antibodies, fully human antibodies, low internalizing (including non-internalizing) antibodies, and antibodies efficiently inducing ADCC and/or ADCP in Treg cells.

Abstract: An exercise bike includes a frame, a rotor assembly and a drive assembly mounted on the frame, where the drive assembly is configured to drive rotation of the rotor assembly, and a cover configured to at least partially cover the rotor assembly. The components of the drive assembly and the rotor assembly include structures that improve the performance of the exercise bike, including but not limited to a strong and rigid construction and improvements in belt tracking, user feel, effort consistency, synchronization, and rotor performance.

Abstract: Data processing systems and methods, according to various embodiments, are adapted for determining a categorization for each tracking tool that executes on a particular webpage based on a variety of criteria, such as the purpose of the tracking tool and its source script. The system may compare the characteristics of tracking tools on a webpage to a database of known tracking tools to determine the appropriate categorization. When a user visits the webpage, the system analyzes these categories and determines whether the tracking tool should be permitted to run based on the categories and/or other criteria, such as whether the user has consented to the use of that type of tracking tool.

Abstract: The present invention relates to a manufacturing process and intermediates for preparing a crystalline or non-crystalline form of N-((1S,3S)-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclobutyl)propane-1-sulfonamide. The present invention also relates to salt forms and pharmaceutical compositions comprising the crystalline form, and to methods for use of the compound prepared from a crystalline form in the treatment of various diseases.

Abstract: Techniques are described for enabling a cloud-based service to provide rate controls for events to be delivered by the service to event targets. An event bus service, for example, broadly enables users to create and configure event buses that receive events from event sources and from which the event bus service filters, transforms, routes, and delivers events to selected event targets according to configurable rules. A new event egress call pattern is provided that estimates a rate of attempted event traffic to event targets and a rate of successfully delivered event traffic (also referred to as a local rate estimation), and that uses the rate estimations to determine when it may be appropriate to throttle event delivery, thereby reducing stress on downstream systems experiencing capacity issues and potentially reducing a number of event delivery retries to be handled by the event bus service.

Abstract: A system is configured to simulate outages of network resources. The system is configured to provide a control plane for computing resources of a provider network. The control plane is configured to cause simulated outages of a primary region of the plurality of regions selected to host the plurality of different computing resources. During the simulated outages, the control plane moves respective workloads of the plurality of different computing resources to be performed in the one or more secondary networks and tracks a performance of the one or more secondary regions hosting the moved respective workloads of the plurality of computing resources. After completing individual ones of the simulated outages of the first network, the control plane moves the respective workloads of the plurality of different computing resources back to the primary region.

Abstract: A vertical internal coating machine is taught, which may be used with bodies such as cans (2 piece, 3 piece, draw, redraw) and including cylinders, containers and any similar body. In the machine cans or similar bodies are sprayed with the star wheel in continuous motion without stopping and starting. The machine teaches that a plurality of spray guns may be provided for each pocket of the star wheel. By means of the machine an improved line layout is devised which may eliminate the need to raise the bodies immediately prior to a necker by allowing the vertical can internal coating machine and internal bake oven to be disposed on any level of the facility, upper, lower, mezzanine, etc. In green aspects, the machine may use negative pressure cabinets/hoods and positive pressure tunnels to entrain volatile organic chemicals emitted by the spray guns and coated bodies and may send these VOCs to a VOC destruction device, such as an oven.