Abstract: Antibodies having enhanced biodistribution and/or pharmacokinetics obtained through disruption of one or more clusters of surface-exposed positively charged amino acids are provided. Also provided are methods of enhancing the biodistribution and/or pharmacokinetics of an antibody. The enhanced antibodies find use in immunotherapy, radiotherapy, and in vivo imaging.

Abstract: Aspects of the present disclosure relate generally to novel antigen binding sequences and uses thereof. More specifically, certain features of the present disclosure concern antibodies, minibodies, and cys-diabodies for use in targeting the protein FAP. The antigen binding sequences herein may be used as part of treatment to confer health benefits to subjects in need thereof. The antigen binding sequences can also be used for detection, targeting, and imaging purposes.

Abstract: The present invention relates generally to a portable coring machine for penetrating a surface to install or repair sub-surface structures. Coring machine may include a frame assembly and a drilling device. Frame assembly may include a plurality of interconnected bars and facilitate operating drilling device in a generally horizontal position or in a generally vertical position. Further, frame assembly may accommodate core bits of different sizes for cutting an annular hole into asphalt, concrete or other hard surface. Support members of frame assembly may be configured to support a track including a plurality of teeth. The track may engage with a gear assembly of a mounting block configured to support the drilling device. Advantageously, coring machine may be moveable along track in response to an operator rotating a crank mechanically coupled to the gear assembly.

Abstract: A cooking grate for a grill is provided having substantially hollow rungs in fluid communication with each other and/or with a substantially hollow border to provide improved thermal management and more efficient heat transfer.

Abstract: The present invention relates generally to a claw device for installing, removing, and repairing a manhole assembly. Claw device may include a base assembly and two or more arm assemblies. The arm assemblies may be configured to pivot in response to movement of a slide along an axis of a shaft extending upwardly from base assembly. In particular, when a lifting force is applied to the slide, one or more grip pads of arm assemblies may be configured to move inwardly toward the shaft and frictionally grip a surface of the manhole assembly. In one aspect, at least one arm assembly includes an extending member having a plurality of positions for adjusting the length of at least one arm assembly. Advantageously, claw device may be adjusted to accommodate for manhole assemblies of different diameters or other objects having various shapes and sizes.

Abstract: According to an example, event anomaly analysis and prediction may include accessing a master directed graph that specifies known events and transitions between the known events, and ranking each of the known events. Each of the ranked known events may be clustered into a plurality of anomaly categories. A plurality of rules to analyze new events may be determined based on the plurality of anomaly categories. A determination may be made, based on an application of the plurality of rules to data that is to be analyzed for an anomaly, whether the data includes the anomaly. In response to a determination that the data includes the anomaly, a device associated with the data may be controlled.

Abstract: A cooking grate for a grill is provided having substantially hollow rungs in fluid communication with each other and/or with a substantially hollow border to provide improved thermal management and more efficient heat transfer.

Abstract: A cooking grate for a grill is provided having substantially hollow rungs in fluid communication with each other and/or with a substantially hollow border to provide improved thermal management and more efficient heat transfer.

Abstract: A cooking grate for a grill is provided having substantially hollow rungs in fluid communication with each other and/or with a substantially hollow border to provide improved thermal management and more efficient heat transfer.

Abstract: According to an example, event anomaly analysis and prediction may include accessing a master directed graph that specifies known events and transitions between the known events, and ranking each of the known events. Each of the ranked known events may be clustered into a plurality of anomaly categories. A plurality of rules to analyze new events may be determined based on the plurality of anomaly categories. A determination may be made, based on an application of the plurality of rules to data that is to be analyzed for an anomaly, whether the data includes the anomaly. In response to a determination that the data includes the anomaly, a device associated with the data may be controlled.

Abstract: According to an example, event anomaly analysis and prediction may include accessing a master directed graph that specifies known events and transitions between the known events, and ranking each of the known events. Each of the ranked known events may be clustered into a plurality of anomaly categories. A plurality of rules to analyze new events may be determined based on the plurality of anomaly categories. A determination may be made, based on an application of the plurality of rules to data that is to be analyzed for an anomaly, whether the data includes the anomaly. In response to a determination that the data includes the anomaly, a device associated with the data may be controlled.

Abstract: According to an example, event anomaly analysis and prediction may include accessing a master directed graph that specifies known events and transitions between the known events, and ranking each of the known events. Each of the ranked known events may be clustered into a plurality of anomaly categories. A plurality of rules to analyze new events may be determined based on the plurality of anomaly categories. A determination may be made, based on an application of the plurality of rules to data that is to be analyzed for an anomaly, whether the data includes the anomaly. In response to a determination that the data includes the anomaly, a device associated with the data may be controlled.

Abstract: The present invention pertains to a system for processing semiconductor wafers. The processing may involve the removal of material from the wafers or deposition of material on the wafers. Various aspects of the invention include specialized pressurization, process vessel, recirculation, chemical addition, depressurization, and recapture-recycle subsystems. A solvent delivery mechanism can convert a liquid-state sub-critical solution to a supercritical processing solution and introduce it into a process vessel that contains a batch of wafers. The wafers may be rotated within the supercritical processing solution. The supercritical processing solution is preferably recirculated through the process vessel by a recirculation system. When chemical additives are added to a supercritical solvent, the momentum of the chemical additives are preferably matched to the momentum of the supercritical solvent. Additives may be added at a higher initial flow rate, then ramped down a lower flow rate, e.g.

Abstract: A filtering device for a gravity-flow liquid treatment system includes a first filter component that can be either exposed or adjacent to a substantially transparent region in at least a portion of a filter housing. The first filter component is capable of providing a visual indication of exposure to at least one contaminant. The contaminants for which the first filter component can indicate exposure include particles, inorganic, and organic contamination. Particle contamination is indicated by a change in color of the first filter component through particle collection. Inorganic and organic contaminants are indicated by reaction with at least one agent capable of undergoing a color-change reaction in response to at least one contaminant.

Abstract: The present invention pertains to apparatus and methods for introduction of solid precursors and reactants into a supercritical fluid reactor. Solids are dissolved in supercritical fluid solvents in generator apparatus separate from the supercritical fluid reactor. Such apparatus preferably generate saturated solutions of solid precursors via recirculation of supercritical fluids through a vessel containing the solid precursors. Supercritical solutions of the solids are introduced into the reactor, which itself is charged with a supercritical fluid. Supercritical conditions are maintained during the delivery of the dissolved precursor to the reactor. Recirculation of supercritical precursor solutions through the reactor may or may not be implemented in methods of the invention. Methods of the invention are particularly well suited for integrated circuit fabrication, where films are deposited on wafers under supercritical conditions.

Abstract: A filtering device for a gravity-flow liquid treatment system includes a first filter component that can be either exposed or adjacent to a substantially transparent region in at least a portion of a filter housing. The first filter component is capable of providing a visual indication of exposure to at least one contaminant. The contaminants for which the first filter component can indicate exposure include particles, inorganic, and organic contamination. Particle contamination is indicated by a change in color of the first filter component through particle collection. Inorganic and organic contaminants are indicated by reaction with at least one agent capable of undergoing a color-change reaction in response to at least one contaminant.

Abstract: An amplifier assembly includes a heat sink and a plurality of amplifier stages, where the total power rating of the amplifier stages is greater than the power rating of the heat sink. The heat sink can have a power rating of 50 watts and can include two amplifier stages, each having a power rating of 50 watts. In an alarm system, each amplifier is able to power one or more selected alarm loops. One of the plurality of amplifier stages acts as a backup amplifier for any of the other amplifier stages in the event of an amplifier stage failure. Also, the amount of power produced by the amplifier stages is flexibly controlled by the alarm system.