Patents by Inventor Patrick K. Lai

Patrick K. Lai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid and polypeptide p10 of a Borna Disease virus (BDV) and their use for diagnostic and immunization purposes
    Patent number: 6740486
    Abstract: One aspect of the present invention is a polypeptide having at least one bioactivity of a polypeptide p10 of a Borna Disease Virus. A second aspect of the present invention is a specific binding member, such as an antibody, that binds with at least a portion of a polypeptide p10 of a Borna Disease Virus. A third aspect of the present invention is a nucleic acid molecule that encodes a polypeptide having at least one bioactivity of a polypeptide p10 of a Borna Disease Virus. A fourth aspect of the present invention is a test kit that includes at least one of: a polypeptide of the present invention, a specific binding member of the present invention or a nucleic acid molecule of the present invention. A fifth aspect of the present invention is a vaccine and method of immunization that includes at least one of: a polypeptide of the present invention, a specific binding member of the present invention or a nucleic acid molecule of the present invention.
    Type: Grant
    Filed: February 23, 2001
    Date of Patent: May 25, 2004
    Assignee: Salem International University (Salem-Teikyo University)
    Inventors: Patrick K. Lai, Tahir H. Malik
  • Protein having anti-HIV activity and method for obtaining it
    Patent number: 5643881
    Abstract: A protein having potent anti-HIV activity is obtained by a method which comprises culturing a strain of CD4-positive T cells, such as a subclone of CEM cells designated 4084, in a tissue culture medium under conditions in which the cells are induced to produce and secrete a protein having anti-HIV activity, separating the cells from the culture medium containing the protein and then recovering the protein from the medium, wherein the molecular weight of the protein having anti-HIV activity is at least 30,000 daltons as determined by a membrane with defined pore size that retains molecules of 30,000 daltons.
    Type: Grant
    Filed: August 4, 1994
    Date of Patent: July 1, 1997
    Assignee: Tampa Bay Research Institute
    Inventors: Meihan Nonoyama, Akiko Tanaka, Patrick K. Lai
  • Process for obtaining cellular protein having anti-HIV activity
    Patent number: 5480782
    Abstract: A process for obtaining cellular protein having potent anti-HIV activity comprises culturing CD4-positive T cells or myeloid cells in a tissue culture medium under conditions in which the cells are induced to produce and secrete a protein having anti-HIV activity, separating the cells from the culture medium containing the protein and then recovering the protein from the medium, wherein the molecular weight of the protein having anti-HIV activity, as measured by gel filtration analysis, is within the range of about 7,000 to about 12,000 daltons.
    Type: Grant
    Filed: August 4, 1994
    Date of Patent: January 2, 1996
    Assignee: Tampa Bay Research Institute
    Inventors: Meihan Nonoyama, Akiko Tanaka, Patrick K. Lai
  • Methods of inhibiting HIV replication in vitro using polymers of p-hydroxylated cinnamic acids
    Patent number: 5346695
    Abstract: Polymers of p-hydroxylated cinnamic acids and p-hydroxylated cinnamyl alcohols have potent anti-viral activity in vitro.
    Type: Grant
    Filed: December 28, 1992
    Date of Patent: September 13, 1994
    Assignee: Tampa Bay Research Institute
    Inventors: Meihan Nonoyama, Akiko Tanaka, Patrick K. Lai, Kunio Konno, Yutaka Kawazoe, Hiroshi Sakagami
  • Process for obtaining cellular protein having anti-HIV activity
    Patent number: 5346988
    Abstract: A process for obtaining cellular protein having potent anti-HIV activity comprises culturing CD4-positive T cells or myeloid cells in a tissue culture medium under conditions in which the cells are induced to produce and secrete a protein having anti-HIV activity, separating the cells from the culture medium containing the protein and then recovering the protein from the medium, wherein the molecular weight of the protein having anti-HIV activity, as measured by gel filtration analysis, is within the range of about 7,000 to about 12,000 daltons.
    Type: Grant
    Filed: February 22, 1991
    Date of Patent: September 13, 1994
    Assignee: Tampa Bay Research Institute
    Inventors: Meihan Nonoyama, Akiko Tanaka, Patrick K. Lai