Patents by Inventor Patrick Koenig
Patrick Koenig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20250124008Abstract: A method of handling a dataset for a build pipeline comprises receiving, from a build service, a query for information related to a dataset being in a first format not managed by the build service for a build pipeline; providing, to the build service, first information related to change in the dataset since a last build performed by the build service in a second format managed by the build service, the first information indicating a version of the dataset used in the last build; transmitting, to the build service, a request for information regarding a new build performed based on the first information; receiving, from the build service, second information regarding the dataset generated from the new build in the second format; storing a new version of the dataset in the first format based on the second information.Type: ApplicationFiled: September 25, 2024Publication date: April 17, 2025Inventors: PATRICK KOENIG, PAUL NEPYWODA, ROBERT FINK
-
Publication number: 20250109195Abstract: The invention provides dual specific antibodies and methods of making and using such antibodies. In general, the dual specific antibodies are generated by identification of a monospecific antibody having light chain variable region VL residues that are electrostatic or hydrophobic and altering the nucleic acid sequence encoding one or more solvent accessible residues in the VH of the antibody either alone or in combination with alteration of the nucleic acid sequence encoding the VL of the antibody. The altered VH and the VL are expressed and dual specific antibodies, or antigen-binding fragments thereof, are selected. Exemplary dual specific antibodies are also provided as well as methods of using the antibodies.Type: ApplicationFiled: December 13, 2024Publication date: April 3, 2025Inventors: Germaine FUH, Chingwei V. LEE, Patrick KOENIG
-
Publication number: 20250084172Abstract: The present disclosure relates to a ULBP6 binding protein that inhibits the interaction between ULBP6 and NKG2D, and methods of treating cancer with said ULBP6 binding protein.Type: ApplicationFiled: July 15, 2024Publication date: March 13, 2025Applicants: 23andMe, Inc., Glaxosmithkline Intellectual Property (No.3) LtdInventors: Joel Benjamin, Shashank Bharill, I-Ling Chen, Yu Chen, Wei-Jen Chung, Zahra Bahrami Dizicheh, Germaine Fuh, Patrick Koenig, Yujie Liu, Mauro Poggio, Shruti Yadav, Ping-Chiao Tsai, Claus Spitzfaden
-
Patent number: 12121586Abstract: The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.Type: GrantFiled: December 21, 2020Date of Patent: October 22, 2024Assignee: Genentech, Inc.Inventors: Patrick Koenig, Chingwei Vivian Lee, Karthikan Rajagopal, Amin Famili, Germaine Fuh
-
Patent number: 12105682Abstract: A method comprises receiving, at a build service of a build server, an external dataset and an adaptor application module, the external dataset being in a specific format, the adaptor application module providing information relevant to a build pipeline maintained by the build service for building an output dataset based on the external dataset, the information including changes to the external dataset since a previous build of the output dataset is performed and a data schema used in the previous build, the build pipeline involving data only in one or more formats other than the specific format; incorporating the external dataset into the build pipeline without the external dataset being reformatted in accordance with requirements of the build service; receiving a request from the adaptor application module for specific information relating to a most recent data build run by the build service; providing a response to the adaptor application module.Type: GrantFiled: October 17, 2023Date of Patent: October 1, 2024Assignee: Palantir Technologies Inc.Inventors: Patrick Koenig, Paul Nepywoda, Robert Fink
-
Publication number: 20240279327Abstract: The invention provides dual specific antibodies and methods of making and using such antibodies. In general, the dual specific antibodies are generated by identification of a monospecific antibody having light chain variable region VL residues that are electrostatic or hydrophobic and altering the nucleic acid sequence encoding one or more solvent accessible residues in the VH of the antibody either alone or in combination with alteration of the nucleic acid sequence encoding the VL of the antibody. The altered VH and the VL are expressed and dual specific antibodies, or antigen-binding fragments thereof, are selected. Exemplary dual specific antibodies are also provided as well as methods of using the antibodies.Type: ApplicationFiled: April 29, 2024Publication date: August 22, 2024Inventors: Germaine FUH, Chingwei V. LEE, Patrick KOENIG
-
Patent number: 12060426Abstract: The present disclosure relates to a ULBP6 binding protein that inhibits the interaction between ULBP6 and NKG2D, and methods of treating cancer with said ULBP6 binding protein.Type: GrantFiled: April 28, 2023Date of Patent: August 13, 2024Assignee: 23andMe, Inc.Inventors: Joel Benjamin, Shashank Bharill, I-Ling Chen, Yu Chen, Wei-Jen Chung, Zahra Bahrami Dizicheh, Germaine Fuh, Patrick Koenig, Yujie Liu, Mauro Poggio, Shruti Yadav, Ping-Chiao Tsai, Claus Spitzfaden
-
Patent number: 12006360Abstract: The invention provides dual specific antibodies capable of binding interleukin 4 (IL4) and interleukin 5 (IL5) and methods of making and using such antibodies. In general, the dual specific antibodies capable of binding IL4 and IL5 are generated by identification of a monospecific antibody having light chain variable region VL residues that are electrostatic or hydrophobic and altering the nucleic acid sequence encoding one or more solvent accessible residues in the VH of the antibody either alone or in combination with alteration of the nucleic acid sequence encoding the VL of the antibody. The altered VH and the VL are expressed and dual specific antibodies, or antigen-binding fragments thereof, are selected.Type: GrantFiled: April 28, 2020Date of Patent: June 11, 2024Assignee: Genentech, Inc.Inventors: Germaine Fuh, Chingwei V. Lee, Patrick Koenig
-
Publication number: 20240086376Abstract: A method comprises receiving, at a build service of a build server, an external dataset and an adaptor application module, the external dataset being in a specific format, the adaptor application module providing information relevant to a build pipeline maintained by the build service for building an output dataset based on the external dataset, the information including changes to the external dataset since a previous build of the output dataset is performed and a data schema used in the previous build, the build pipeline involving data only in one or more formats other than the specific format; incorporating the external dataset into the build pipeline without the external dataset being reformatted in accordance with requirements of the build service; receiving a request from the adaptor application module for specific information relating to a most recent data build run by the build service; providing a response to the adaptor application module.Type: ApplicationFiled: October 17, 2023Publication date: March 14, 2024Inventors: PATRICK KOENIG, PAUL NEPYWODA, ROBERT FINK
-
Patent number: 11891437Abstract: The present invention provides antibody conjugates that include antibodies (e.g., anti-VEGF antibodies) covalently linked to polymers (e.g., hyaluronic acid (HA) polymers), cysteine engineered antibodies, pharmaceutical compositions thereof, and uses thereof, for example for treatment of disorders associated with pathological angiogenesis (e.g., ocular disorders).Type: GrantFiled: August 3, 2021Date of Patent: February 6, 2024Assignee: Genentech, Inc.Inventors: Amin Famili, Germaine Fuh, Patrick Koenig, Chingwei Vivian Lee, Karthikan Rajagopal
-
Publication number: 20230348604Abstract: The present disclosure relates to a ULBP6 binding protein that inhibits the interaction between ULBP6 and NKG2D, and methods of treating cancer with said ULBP6 binding protein.Type: ApplicationFiled: April 28, 2023Publication date: November 2, 2023Applicants: 23andMe, Inc., GLAXOSMITHKLINE INTELLECTUAL PROPERTY (No.3) LIMITEDInventors: Joel BENJAMIN, Shashank BHARILL, I-Ling CHEN, Yu CHEN, Wei-Jen CHUNG, Zahra Bahrami DIZICHEH, Germaine FUH, Patrick KOENIG, Yujie LIU, Mauro POGGIO, Shruti YADAV, Ping-Chiao TSAI, Claus SPITZFADEN
-
Patent number: 11789912Abstract: A method is disclosed, comprising receiving, at a build service, an external dataset and an adaptor associated with the external dataset, the external dataset being in a format which is not managed by the build server. The method may also comprise querying the adaptor, by the build service, for information related to the external dataset. The method may also comprise receiving, at the build service, the information related to the external dataset; and causing, by the build service, the external dataset to be input into a build pipeline using the information related to the external dataset.Type: GrantFiled: June 6, 2022Date of Patent: October 17, 2023Assignee: PALANTIR TECHNOLOGIES INC.Inventors: Patrick Koenig, Paul Nepywoda, Robert Fink
-
Publication number: 20220414239Abstract: Computing systems and methods are provided for defining, within a data platform, a segment having constraints at a level of the segment, implementing the constraints or the classification rules within the segment while insulating resources within the segment from inheriting the constraints, and controlling an ingestion of an external resource into the segment based on the constraints.Type: ApplicationFiled: June 24, 2022Publication date: December 29, 2022Inventors: Christopher Yu, Hannah Korus, Katherine Carras, Kevin Lowe, Lam Tran, Patrick Koenig, Sebastian Brueckner, Thomas Playford, Yin Lin
-
Publication number: 20220365911Abstract: A method is disclosed, comprising receiving, at a build service, an external dataset and an adaptor associated with the external dataset, the external dataset being in a format which is not managed by the build server. The method may also comprise querying the adaptor, by the build service, for information related to the external dataset. The method may also comprise receiving, at the build service, the information related to the external dataset; and causing, by the build service, the external dataset to be input into a build pipeline using the information related to the external dataset.Type: ApplicationFiled: June 6, 2022Publication date: November 17, 2022Inventors: PATRICK KOENIG, PAUL NEPYWODA, ROBERT FINK
-
Patent number: 11354281Abstract: A method is disclosed, comprising receiving, at a build service, an external dataset and an adaptor associated with the external dataset, the external dataset being in a format which is not managed by the build server. The method may also comprise querying the adaptor, by the build service, for information related to the external dataset. The method may also comprise receiving, at the build service, the information related to the external dataset; and causing, by the build service, the external dataset to be input into a build pipeline using the information related to the external dataset.Type: GrantFiled: November 16, 2017Date of Patent: June 7, 2022Assignee: PALANTIR TECHNOLOGIES INC.Inventors: Patrick Koenig, Paul Nepywoda, Robert Fink
-
Publication number: 20210363231Abstract: The present invention provides antibody conjugates that include antibodies (e.g., anti-VEGF antibodies) covalently linked to polymers (e.g., hyaluronic acid (HA) polymers), cysteine engineered antibodies, pharmaceutical compositions thereof, and uses thereof, for example for treatment of disorders associated with pathological angiogenesis (e.g., ocular disorders).Type: ApplicationFiled: August 3, 2021Publication date: November 25, 2021Inventors: Amin FAMILI, Germaine FUH, Patrick KOENIG, Chingwei Vivian LEE, Karthikan RAJAGOPAL
-
Patent number: 11111291Abstract: The present invention provides antibody conjugates that include antibodies (e.g., anti-VEGF antibodies) covalently linked to polymers (e.g., hyaluronic acid (HA) polymers), cysteine engineered antibodies, pharmaceutical compositions thereof, and uses thereof, for example for treatment of disorders associated with pathological angiogenesis (e.g., ocular disorders).Type: GrantFiled: September 17, 2019Date of Patent: September 7, 2021Assignee: Genetech, Inc.Inventors: Amin Famili, Germaine Fuh, Patrick Koenig, Chingwei Vivian Lee, Karthikan Rajagopal
-
Publication number: 20210115124Abstract: The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.Type: ApplicationFiled: December 21, 2020Publication date: April 22, 2021Inventors: Patrick KOENIG, Chingwei Vivian LEE, Karthikan RAJAGOPAL, Amin FAMILI, Germaine FUH
-
Patent number: 10906968Abstract: The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.Type: GrantFiled: July 12, 2018Date of Patent: February 2, 2021Assignee: Genentech, Inc.Inventors: Patrick Koenig, Chingwei Vivian Lee, Karthikan Rajagopal, Amin Famili, Germaine Fuh
-
Patent number: 10899828Abstract: The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.Type: GrantFiled: July 12, 2018Date of Patent: January 26, 2021Assignee: Genentech, Inc.Inventors: Patrick Koenig, Chingwei Vivian Lee, Karthikan Rajagopal, Amin Famili, Germaine Fuh