Abstract: Disclosed herein are engineered cytokines, compositions and uses thereof, and in silico methods for engineering cytokines generated from artificial neural network machine learning protocols and/or molecular dynamics simulations. Also disclosed herein are poly peptide structures designed using AI methods with modulated stability, potency and developability. Also disclosed herein are compositions containing engineered cytokine for pharmaceutical use, as well as methods of treating a subject by administering to the subject compositions containing the same.

Abstract: A method and system for correlating content with linear media. More particularly, but not exclusively, the method and system correlate synchronous content with linear media by linking the content to a portion of the linear media, and including creating content related to the linear media; identifying a portion of the linear media corrected to the content; and linking the content to the portion; wherein the content is not synchronized with the linear media and the content is created non-contemporaneously with creation of the linear media.