Abstract: Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.

Abstract: Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.

Abstract: Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.

Abstract: Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.

Abstract: Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.

Abstract: Systems and methods are shown for developing physics-based high resolution biomechanical head and neck deformable models for generating ground-truth deformations that can be used for validating both image registration and adaptive RT frameworks.

Abstract: Systems and methods are shown for developing physics-based high resolution biomechanical head and neck deformable models for generating ground-truth deformations that can be used for validating both image registration and adaptive RT frameworks.

Abstract: The present invention provides a method for estimation of retrospective and real-time 3D target position by a single imager. The invention includes imaging a target on at least one 2D plane to determine 2D position and/or position components of the target, and resolving a position and/or position component along at least one imager axis of the target using a spatial probability density. The present invention provides a probability-based method for accurate estimation of the mean position, motion magnitude, motion correlation, and trajectory of a tumor from CBCT projections. The applicability of the method for tumors with periodic respiratory motion and for prostate are provided. Clinical feasibility is demonstrated for a pancreas tumor. The method includes monoscopic tracking of the 3D prostate position utilizing the spatial probability density to estimate the unresolved motion from the resolved motion. The method is applicable to prostate tracking even with a population-based probability density.

Abstract: The present invention provides a method for estimation of retrospective and real-time 3D target position by a single imager. The invention includes imaging a target on at least one 2D plane to determine 2D position and/or position components of the target, and resolving a position and/or position component along at least one imager axis of the target using a spatial probability density. The present invention provides a probability-based method for accurate estimation of the mean position, motion magnitude, motion correlation, and trajectory of a tumor from CBCT projections. The applicability of the method for tumors with periodic respiratory motion and for prostate are provided. Clinical feasibility is demonstrated for a pancreas tumor. The method includes monoscopic tracking of the 3D prostate position utilizing the spatial probability density to estimate the unresolved motion from the resolved motion. The method is applicable to prostate tracking even with a population-based probability density.