Abstract: The present invention relates to methods of determining whether a patient responds to a therapeutic treatment of multiple sclerosis (MS), of monitoring the course of multiple sclerosis (MS) in a patient, of determining the risk for a relapse of multiple sclerosis (MS) in a patient, and of adjusting the dose of a therapeutic drug applied for therapeutic treatment of multiple sclerosis in a patient. Said methods are based on the determination of the level of at least one miRNA in a test sample isolated from the patient. The present invention also relates to a method of identifying a compound suitable for the treatment of multiple sclerosis in a patient.

Abstract: A minute hand of a timepiece has a central arbor, on which, for driving around the same: a gearwheel is fixed in a first accommodating region, a flyback device is fixed in a second accommodating region, and a snail cam is arranged with an interference fit in a third accommodating region. The snail cam has an opening for accommodating the head of an eccentric and the flyback device has an opening for accommodating the finger of the eccentric, and therefore rotation of the eccentric head, via the flyback device fixed on the central arbor, makes it possible to rotate the snail cam by an angle about the central arbor relative to the gearwheel for setting the triggering point of the advancement operation by the minute control level.

Abstract: A timepiece includes: —a barrel bridge (33), and—a barrel mounted on the barrel bridge, the barrel having: —a drum (20) which includes an end wall and side walls, —an arbor (14) which passes through the center of the drum, —a leaf spring housed in the drum and engaging at a first end with the arbor and at a second end with the drum, and—a cover (28) through which the arbor passes freely and which closes the drum, —a ratchet wheel (30) secured to the arbor to tension the leaf spring. The drum is pivoted by a first ball bearing including an intermediate ring (36), an inner ring (42) secured to the arbor and an outer ring (38), one of the intermediate ring and the outer ring being fixed to the barrel bridge and the other being secured to the end wall.

Abstract: A mechanical watch comprises a motive spring in a first spring barrel and a mechanical and/or automatic winding device. A second spring barrel and a differential having three drive trains are provided, wherein the train connected to the winding device acts on the first and second spring barrels in the same direction.

Abstract: A timepiece includes:—a barrel bridge (33), and—a barrel mounted on the barrel bridge, the barrel having:—a drum (20) which includes an end wall and side walls,—an arbor (14) which passes through the centre of the drum,—a leaf spring housed in the drum and engaging at a first end with the arbor and at a second end with the drum, and—a cover (28) through which the arbor passes freely and which closes the drum,—a ratchet wheel (30) secured to the arbor to tension the leaf spring. The drum is pivoted by a first ball bearing including an intermediate ring (36), an inner ring (42) secured to the arbor and an outer ring (38), one of the intermediate ring and the outer ring being fixed to the barrel bridge and the other being secured to the end wall.

Abstract: A timepiece includes a platen (10) and a barrel mounted on the platen, the barrel including: a drum (20) with a bottom and side walls; a shaft (14) extending through the drum at the center thereof and provided with pivoting elements (40, 54) on the platen; a leaf spring provided in the drum and co-operating with the shaft at one end and with the drum at the other end; and a lid (28) through which the shaft extends and closing the drum, a ratchet wheel (30) being kinematically connected to the shaft for winding the spring. According to the invention, the drum is pivoted via a first ball bearing (34) having a bushing (36) connected to the platen and another bushing (38) connected to the bottom of the drum.

Abstract: A timepiece includes a platen (10) and a barrel mounted on the platen, the barrel including: a drum (20) with a bottom and side walls; a shaft (14) extending through the drum at the centre thereof and provided with pivoting elements (40, 54) on the platen; a leaf spring provided in the drum and co-operating with the shaft at one end and with the drum at the other end; and a lid (28) through which the shaft extends and closing the drum, a ratchet wheel (30) being kinematically connected to the shaft for winding the spring. According to the invention, the drum is pivoted via a first ball bearing (34) having a bushing (36) connected to the platen and another bushing (38) connected to the bottom of the drum.

Abstract: A mechanical watch comprises a motive spring in a first spring barrel and a mechanical and/or automatic winding device. A second spring barrel and a differential having three drive trains are provided, wherein the train connected to the winding device acts on the first and second spring barrels in the same direction.

Abstract: A watch includes a conventional hour hand and minute hand. The watch also includes a time zone display with a window in which information regarding a time zone is placed on a disc. This time zone includes a time display comprising at least one hour display, which may also be realized by a window in that an hour display for the displayed time zone is placed on a disc. A crown with a depressor is then provided, which is mechanically connected to the time zone display or the time display for the displayed time zone such that, by actuating the depressor, at least the hour hand may be brought into synchronization with the time zone determined by the time zone display. In this manner, the new local time may be set according to a predetermined time zone by a single operation without stopping the clockwork.