Patents by Inventor Patrick L. Moore

Patrick L. Moore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dual-fluorescence cell viability assay using ethidium homodimer and calcein AM
    Patent number: 5314805
    Abstract: This invention relates to a method for simultaneously detecting live and dead cells using two fluorogenic reagents: calcein AM and ethidium homodimer. Live cells are distinguished by an intense uniform green fluorescence generated by the enzymatic hydrolysis of calcein AM: ##STR1## Dead or damaged cells are distinguished by a bright red fluorescence resulting from nucleic acids stained with ethidium homodimer: ##STR2## The assay is useful to determine cell viability and to monitor cytotoxicity agents or events.
    Type: Grant
    Filed: October 28, 1991
    Date of Patent: May 24, 1994
    Assignee: Molecular Probes, Inc.
    Inventors: Richard P. Haugland, Ian C. MacCoubrey, Patrick L. Moore