Patents by Inventor Patrick Laurén
Patrick Laurén has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11969505Abstract: The present disclosure provides a method for freeze-drying cells in a hydrogel comprising nanofibrillar cellulose, the method comprising providing a hydrogel comprising nanofibrillar cellulose, providing cells, combining the cells and the hydrogel comprising nanofibrillar cellulose to form a cell system, and freeze drying the cell system to obtain dried cells in a hydrogel comprising nanofibrillar cellulose. The present disclosure also provides a freeze-dried hydrogel comprising nanofibrillar cellulose and cells.Type: GrantFiled: April 4, 2022Date of Patent: April 30, 2024Assignee: UPM-KYMMENE CORPORATIONInventors: Heli Paukkonen, Vili-Veli Auvinen, Marjo Yliperttula, Patrick Laurën, Arto Urtti, Timo Laaksonen, Arto Merivaara, Tiina Hakkarainen, Outi Monni, Anne Mäkelä, Petter Somersalo, Piia-Riitta Karhemo, Heikki Joensuu, Raili Koivuniemi, Kari Luukko, Markus Nuopponen
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Patent number: 11850306Abstract: The present disclosure relates to method for drying hydrogel comprising nanofibrillar cellulose, the method comprising providing a hydrogel comprising nanofibrillar cellulose, providing polyethylene glycol, providing trehalose, mixing the hydrogel, the polyethylene glycol and the trehalose to obtain a mixture, and freeze drying the mixture to obtain a dried hydrogel comprising nanofibrillar cellulose. The present disclosure relates to a freeze-dryable hydrogel comprising nanofibrillar cellulose, to a freeze-dried hydrogel comprising nanofibrillar cellulose, and to a medical hydrogel comprising nanofibrillar cellulose and one or more therapeutic agent(s).Type: GrantFiled: December 15, 2017Date of Patent: December 26, 2023Assignee: UPM-KYMMENE CORPORATIONInventors: Vili-Veli Auvinen, Heli Paukkonen, Marjo Yliperttula, Arto Urtti, Tiina Hakkarainen, Patrick Laurén, Mikko Kunnari, Timo Laaksonen, Mingwei Li, Kari Luukko
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Publication number: 20220249378Abstract: The present disclosure provides a method for freeze-drying cells in a hydrogel comprising nanofibrillar cellulose, the method comprising providing a hydrogel comprising nanofibrillar cellulose, providing cells, combining the cells and the hydrogel comprising nanofibrillar cellulose to form a cell system, and freeze drying the cell system to obtain dried cells in a hydrogel comprising nanofibrillar cellulose. The present disclosure also provides a freeze-dried hydrogel comprising nanofibrillar cellulose and cells.Type: ApplicationFiled: April 4, 2022Publication date: August 11, 2022Inventors: Heli PAUKKONEN, Vili-Veli AUVINEN, Marjo YLIPERTTULA, Patrick LAURÉN, Arto URTTI, Timo LAAKSONEN, Arto MERIVAARA, Tiina HAKKARAINEN, Outi MONNI, Anne MÄKELÄ, Petter SOMERSALO, Piia-Riitta KARHEMO, Heikki JOENSUU, Raili KOIVUNIEMI, Kari LUUKKO, Markus NUOPPONEN
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Patent number: 11324701Abstract: The present disclosure provides a method for freeze-drying cells in a hydrogel comprising nanofibrillar cellulose, the method comprising providing a hydrogel comprising nanofibrillar cellulose, providing cells, combining the cells and the hydrogel comprising nanofibrillar cellulose to form a cell system, and freeze drying the cell system to obtain dried cells in a hydrogel comprising nanofibrillar cellulose. The present disclosure also provides a freeze-dried hydrogel comprising nanofibrillar cellulose and cells.Type: GrantFiled: August 25, 2017Date of Patent: May 10, 2022Assignee: UPM-KYMMENE CORPORATIONInventors: Heli Paukkonen, Vili-Veli Auvinen, Marjo Yliperttula, Patrick Laurén, Arto Urtti, Timo Laaksonen, Arto Merivaara, Tiina Hakkarainen, Outi Monni, Anne Mäkelä, Petter Somersalo, Piia-Riitta Karhemo, Heikki Joensuu, Raili Koivuniemi, Kari Luukko, Markus Nuopponen
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Publication number: 20210190765Abstract: The present invention relates a method for chemical testing, comprising culturing cells in a first plant-derived nanofibrillar cellulose (NFC)hydrogel to obtain in vivo like cells; exposing the in vivo like cells to a test chemical; optionally within another plant-derived NFC hydrogel; incubating the exposed in vivo like cells; detecting during or after incubating, the impact of the test chemical on the in vivo like cells by at least one detection; and removing the plant-derived NFC hydrogel at least once at any stage after obtaining the in vivo like cells and before at least one detection used for detecting the impact of the test chemical on the in vivo like cells. The invention further relates to the use of plant-derived NFC hydrogel in a method for chemical testing, the use of in vivo like cells obtained by culturing cells in plant-derived NFC hydrogel for chemical testing and to a kit for chemical testing comprising plant-derived NFC hydrogel, instructions and a cell or test chemical library.Type: ApplicationFiled: March 2, 2021Publication date: June 24, 2021Inventors: Marjo Yliperttula, Arto Urtti, Yan-Ru Lou, Melina Malinen, Patrick Laurén, Liisa Kanninen, Kirsti Johanna Niklander, Petter Somersalo, Riina Harjumäki
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Publication number: 20210127663Abstract: The present disclosure provides a method for freeze-drying cells in a hydrogel comprising nanofibrillar cellulose, the method comprising providing a hydrogel comprising nanofibrillar cellulose, providing cells, combining the cells and the hydrogel comprising nanofibrillar cellulose to form a cell system, and freeze drying the cell system to obtain dried cells in a hydrogel comprising nanofibrillar cellulose. The present disclosure also provides a freeze-dried hydrogel comprising nanofibrillar cellulose and cells.Type: ApplicationFiled: August 25, 2017Publication date: May 6, 2021Inventors: Heli PAUKKONEN, Vili-Veli AUVINEN, Marjo YLIPERTTULA, Patrick LAURÉN, Arto URTTI, Timo LAAKSONEN, Arto MERIVAARA, Tiina HAKKARAINEN, Outi MONNI, Anne MÄKELÄ, Petter SOMERSALO, Piia-Riitta KARHEMO, Heikki JOENSUU, Raili KOIVUNIEMI, Kari LUUKKO, Markus NUOPPONEN
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Patent number: 10976308Abstract: The present invention relates a method for chemical testing, comprising culturing cells in a first plant-derived nanofibrillar cellulose (NFC) hydrogel to obtain in vivo like cells; exposing the in vivo like cells to a test chemical; optionally within another plant-derived NFC hydrogel; incubating the exposed in vivo like cells; detecting during or after incubating, the impact of the test chemical on the in vivo like cells by at least one detection; and removing the plant-derived NFC hydrogel at least once at any stage after obtaining the in vivo like cells and before at least one detection used for detecting the impact of the test chemical on the in vivo like cells. The invention further relates to the use of plant-derived NFC hydrogel in a method for chemical testing, the use of in vivo like cells obtained by culturing cells in plant-derived NFC hydrogel for chemical testing and to a kit for chemical testing comprising plant-derived NFC hydrogel, instructions and a cell or test chemical library.Type: GrantFiled: December 18, 2015Date of Patent: April 13, 2021Assignee: UPM-KYMMENE CORPORATIONInventors: Marjo Yliperttula, Arto Urtti, Yan-Ru Lou, Melina Malinen, Patrick Laurén, Liisa Kanninen, Kirsti Johanna Niklander, Petter Somersalo, Riina Harjumäki
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Patent number: 10729804Abstract: The present invention relates to the use of nanofibrillar cellulose hydrogel in cell culture and medical applications. The invention relates to a composition comprising nanofibrillar cellulose, cross linkable polymer and at least one bioactive agent. The invention also provides methods for producing the composition and uses thereof. The present invention further relates to the use of said composition for manufacturing of a shaped matrix, the method of preparing said matrix, the matrix and the use of said matrix in various applications.Type: GrantFiled: February 10, 2016Date of Patent: August 4, 2020Assignee: UPM-KYMMENE CORPORATIONInventors: Marjo Yliperttula, Patrick Lauren, Petter Somersalo, Yanru Lou
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Patent number: 10612003Abstract: The present invention relates material that is useful in culturing and transferring cells as well as delivering cells. The material comprises plant derived cellulose nanofibers or derivatives thereof, wherein the cellulose nanofibers are in a form of a hydrogel or membrane. The invention also provides methods for producing these materials and compositions and uses thereof.Type: GrantFiled: October 26, 2011Date of Patent: April 7, 2020Assignee: UPM-KYMMENE CORPORATIONInventors: Marjo Yliperttula, Patrick Laurén, Madhushree Bhattacharya, Yanru Lou, Antti Laukkanen
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Publication number: 20200078305Abstract: The present disclosure relates to method for drying hydrogel comprising nanofibrillar cellulose, the method comprising providing a hydrogel comprising nanofibrillar cellulose, providing polyethylene glycol, providing trehalose, mixing the hydrogel, the polyethylene glycol and the trehalose to obtain a mixture, and freeze drying the mixture to obtain a dried hydrogel comprising nanofibrillar cellulose. The present disclosure relates to a freeze-dryable hydrogel comprising nanofibrillar cellulose, to a freeze-dried hydrogel comprising nanofibrillar cellulose, and to a medical hydrogel comprising nanofibrillar cellulose and one or more therapeutic agent(s).Type: ApplicationFiled: December 15, 2017Publication date: March 12, 2020Inventors: Vili-Veli AUVINEN, Heli PAUKKONEN, Marjo YLIPERTTULA, Arto URTTI, Tiina HAKKARAINEN, Patrick LAURÉN, Mikko KUNNARI, Timo LAAKSONEN, Mingwei LI, Kari LUUKKO
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Publication number: 20180021473Abstract: The present invention relates to the use of nanofibrillar cellulose hydrogel in cell culture and medical applications. The invention relates to a composition comprising nanofibrillar cellulose, cross linkable polymer and at least one bioactive agent. The invention also provides methods for producing the composition and uses thereof. The present invention further relates to the use of said composition for manufacturing of a shaped matrix, the method of preparing said matrix, the matrix and the use of said matrix in various applications.Type: ApplicationFiled: February 10, 2016Publication date: January 25, 2018Inventors: Marjo Yliperttula, Patrick Lauren, Petter Somersalo, Yanru Lou
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Publication number: 20180024121Abstract: The present invention relates a method for chemical testing, comprising culturing cells in a first plant-derived nanofibrillar cellulose (NFC) hydrogel to obtain in vivo like cells; exposing the in vivo like cells to a test chemical; optionally within another plant-derived NFC hydrogel; incubating the exposed in vivo like cells; detecting during or after incubating, the impact of the test chemical on the in vivo like cells by at least one detection; and removing the plant-derived NFC hydrogel at least once at any stage after obtaining the in vivo like cells and before at least one detection used for detecting the impact of the test chemical on the in vivo like cells. The invention further relates to the use of plant-derived NFC hydrogel in a method for chemical testing, the use of in vivo like cells obtained by culturing cells in plant-derived NFC hydrogel for chemical testing and to a kit for chemical testing comprising plant-derived NFC hydrogel, instructions and a cell or test chemical library.Type: ApplicationFiled: December 18, 2015Publication date: January 25, 2018Inventors: Marjo Yliperttula, Arto Urtti, Yan-Ru Lou, Melina Malinen, Patrick Laurén, Liisa Kanninen, Johanna Niklander, Petter Somersalo, Riina Harjumäki
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Patent number: 9631177Abstract: The present invention relates material that is useful in drug delivery compositions. The material comprises cellulose nanofibers and/or derivatives thereof, wherein the cellulose nanofibers are in a form of a hydrogel or membrane. The invention also provides methods for producing these materials and compositions and uses thereof.Type: GrantFiled: October 26, 2011Date of Patent: April 25, 2017Assignee: UPM-KYMMENE CORPORATIONInventors: Marjo Yliperttula, Patrick Laurén, Madhushree Bhattacharya, Yanru Lou, Antti Laukkanen
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Publication number: 20140010790Abstract: The present invention relates material based on microbial cellulose that is useful in culturing and transferring cells as well as delivering drugs. The material comprises cellulose nanofibers and/or derivatives thereof, based on microbial cellulose, wherein the cellulose nanofibers are in a form of a hydrogel or membrane. The invention also provides methods for producing these materials and compositions and uses thereof.Type: ApplicationFiled: October 26, 2011Publication date: January 9, 2014Applicant: UPM-KYMMENE CORPORATIONInventors: Marjo Yliperttula, Patrick Laurén, Madhushree Bhattacharya, Yanru Lou, Antti Loukkanen
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Publication number: 20130344036Abstract: The present invention relates material that is useful in culturing and transferring cells as well as delivering cells. The material comprises plant derived cellulose nanofibers or derivatives thereof, wherein the cellulose nanofibers are in a form of a hydrogel or membrane. The invention also provides methods for producing these materials and compositions and uses thereof.Type: ApplicationFiled: October 26, 2011Publication date: December 26, 2013Applicant: UPM-KYMMENE CORPORATIONInventors: Marjo Yliperttula, Patrick Laurén, Madhushree Bhattacharya, Yanru Lou, Antti Laukkanen
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Publication number: 20130330379Abstract: The present invention relates material that is useful in drug delivery compositions. The material comprises cellulose nanofibers and/or derivatives thereof, wherein the cellulose nanofibers are in a form of a hydrogel or membrane. The invention also provides methods for producing these materials and compositions and uses thereof.Type: ApplicationFiled: October 26, 2011Publication date: December 12, 2013Applicant: UPM-KYMMENE CORPORATIONInventors: Marjo Ylipertula, Patrick Laurén, Madhushree BHhattacharya, Yanru Lou, Antti Laukkanen