Abstract: A memory expansion device operable with a host computer system (host) comprises a non-volatile memory (NVM) subsystem, cache memory, and control logic configurable to receive a submission from the host including a read command and specifying a payload in the NVM subsystem and demand data in the payload. The control logic is configured to request ownership of a set of cache lines corresponding to the payload, to indicate completion of the submission after acquiring ownership of the cache lines, and to load the payload to the cache memory. The set of cache lines correspond to a set of cache lines in a coherent destination memory space accessible by the host. The control logic is further configured to, after indicating completion of the submission and in response to a request from the host to read demand data in the payload, return the demand data after determining that the demand data is in the cache memory.

Abstract: Self-tuning clusters for resilient microservices, including: receiving, by a services orchestrator within a cloud-computing environment and from a plurality of cloud computing instances, respective latency measurements corresponding to respective control plane operations directed to a shared resource of the plurality of cloud computing instances; determining, based on a current timeout value and on the respective latency measurements from the plurality of cloud computing instances, an updated timeout value for the shared resource; and providing, to each of the plurality of cloud computing instances, the updated timeout value for the shared resource.

Abstract: Provided is a tissue staining composition containing carbon particles having a mean particle diameter less than 0.3 ?m in diameter (optionally less than 0.2 ?m in diameter) together with one or more agents that maintain the carbon particles in suspension (for example, an anti-settling agent and/or surfactant). In certain circumstances, the anti-settling agent may also have mucoadhesive properties. The tissue staining composition is visually dark and does not disperse rapidly when introduced into regions of tissue of interest making it ideal for marking the regions that can be visualized clearly and over prolonged periods of time via, for example, direct visualization, endoscopic or laparoscopic inspection. The invention also provides methods of making and using the tissue staining composition for marking regions of tissue of interest, for example, gastrointestinal tissue, as well as other tissues.

Abstract: A memory expansion device operable with a host computer system (host) comprises a non-volatile memory (NVM) subsystem, cache memory, and control logic configurable to receive a submission from the host including a read command and specifying a payload in the NVM subsystem and demand data in the payload. The control logic is configured to request ownership of a set of cache lines corresponding to the payload, to indicate completion of the submission after acquiring ownership of the cache lines, and to load the payload to the cache memory. The set of cache lines correspond to a set of cache lines in a coherent destination memory space accessible by the host. The control logic is further configured to, after indicating completion of the submission and in response to a request from the host to read demand data in the payload, return the demand data after determining that the demand data is in the cache memory.

Abstract: We describe a new genomic signature (MEN1 mut/DAXX wt) that correlates with PNET response to CAPTEM therapy. MEN1-mut/DAXX-wt status correlates with longer progression-free survival on CAPTEM in patients with pancreatic neuroendocrine tumors, relative to patients with MEN1-wt or DAXX-mut.

Abstract: A memory expansion device operable with a host computer system (host) comprises a non-volatile memory (NVM) subsystem, cache memory, and control logic configurable to receive a submission from the host including a read command and specifying a payload in the NVM subsystem and demand data in the payload. The control logic is configured to request ownership of a set of cache lines corresponding to the payload, to indicate completion of the submission after acquiring ownership of the cache lines, and to load the payload to the cache memory. The set of cache lines correspond to a set of cache lines in a coherent destination memory space accessible by the host. The control logic is further configured to, after indicating completion of the submission and in response to a request from the host to read demand data in the payload, return the demand data after determining that the demand data is in the cache memory.

Abstract: A canister apparatus configured to protect and seal a range of jars and perishable items therein from light, dehydration, loss of volatiles, and or rapid change in temperature. The canister apparatus comprising a canister lid, a canister base and a cup fit within the canister base. The canister lid may comprise a gasket and a boss that are sized to accommodate an airtight seal of a jar upon insertion substantially within the canister base. The cup is configured to secure a jar upon insertion substantially within the canister base. The canister apparatus may include a jar and a cover configured to couple to the jar.

Abstract: A chest drainage system including a collection device configured to receive fluid from the pleural cavity of a patient. A sensor is included to detect a pressure differential in the fluid. A display is configured to display a trend in occurrences of changes in pressure of the fluid over time in predetermined time increments based on a number of detections of pressure differentials that exceed a predetermined pressure differential during each of the predetermined time increments. The trend is correlative to the percentage of time that the patient is deemed to have an air leak in the pleural cavity in the predetermined time increments. The trend is derived from a ratio of the quantity of respiratory cycles of the patient for which the predetermined pressure differential is detected (QRCleak) in the predetermined time increments to the total quantity of respiratory cycles of the patient in respective predetermined time increments (QRCtotal).

Abstract: Provided herein are submucosal lifting compositions and methods of using same. The submucosal lifting agents of the disclosure include a polysaccharide, a polyol, and a colorant.

Abstract: A method may include detecting, by a computing device based on a problem signature, that a system has experienced a problem that is associated with the problem signature, wherein the problem signature comprises a specification of a pattern of events indicative of the particular problem experienced by at least one other system; determining that the particular problem violates an operational policy of the system; and deploying one or more corrective measures that modify the system to resolve the problem.

Abstract: A method may include detecting, by a computing device based on a problem signature, that a system has experienced a problem that is associated with the problem signature, wherein the problem signature comprises a specification of a pattern of events indicative of the particular problem experienced by at least one other system; determining that the particular problem violates an operational policy of the system; and deploying, without user intervention, one or more corrective measures that modify the system to resolve the problem.

Abstract: A chest drainage system including a collection device configured to receive fluid from the pleural cavity of a patient. A sensor is included to detect a pressure differential in the fluid. A display is configured to display a trend in occurrences of changes in pressure of the fluid over time in predetermined time increments based on a number of detections of pressure differentials that exceed a predetermined pressure differential during each of the predetermined time increments. The trend is correlative to the percentage of time that the patient is deemed to have an air leak in the pleural cavity in the predetermined time increments. The trend is derived from a ratio of the quantity of respiratory cycles of the patient for which the predetermined pressure differential is detected (QRCleak) in the predetermined time increments to the total quantity of respiratory cycles of the patient in respective predetermined time increments (QRCtotal).

Abstract: A dialysis system includes a dialysis machine comprising a motorized autoconnection mechanism, a fluid supply line connected to a source of dialysis fluid, and a cassette for use with the dialysis machine. The cassette includes a frame, a pump chamber within the frame, a first set of valves for routing the dialysis fluid from the fluid supply line to the pump chamber, and a second set of valves for routing the dialysis fluid from the pump chamber to a patient line. The cassette also includes a plurality of ports communicating with the first and second set of valves. Each port includes an integral spike. The motorized autoconnection mechanism is configured to move the fluid supply line and the patient line automatically so as to be spiked open respectively by the plurality of ports of the cassette.

Abstract: An endoscopic tool for facilitating injection of fluid into a submucosal layer of tissue includes a first cannula, a second cannula, and means for attaching the first cannula to a mucosal layer of tissue. The first cannula has a distal end and a proximal end opposite the distal end. The second cannula is adapted to be coupled to a source of fluid and carries a needle at a distal end thereof. The means for attaching the first cannula to the mucosal layer draws the mucosal layer, which enlarges the submucosal layer. Fluid is then injected into the enlarged portion of the submucosal layer via the needle, thereby creating a raised portion of tissue around the injection site.

Abstract: A dialysis system including a disposable fluid pumping cassette including at least one flexible membrane attached to a housing and at least one port extending from the housing, the at least one port including a spike; at least one dialysis fluid supply in fluid communication with at least one tubing and tubing connector; an autoconnection device including a shuttle for moving the at least one tubing and tubing connector towards the spike of the at least one port, the autoconnection device including at least one lead screw in mechanical communication with the shuttle, a motor and power transmission equipment to transmit power from the motor to the at least one lead screw; and a controller programmed to operate the motor to move the at least one tubing and tubing connector towards the spike of the at least one port of the disposable fluid pumping cassette.

Abstract: A memory expansion device operable with a host computer system (host) comprises a non-volatile memory (NVM) subsystem, cache memory, and control logic configurable to receive a submission from the host including a read command and specifying a payload in the NVM subsystem and demand data in the payload. The control logic is configured to request ownership of a set of cache lines corresponding to the payload, to indicate completion of the submission after acquiring ownership of the cache lines, and to load the payload to the cache memory. The set of cache lines correspond to a set of cache lines in a coherent destination memory space accessible by the host. The control logic is further configured to, after indicating completion of the submission and in response to a request from the host to read demand data in the payload, return the demand data after determining that the demand data is in the cache memory.

Abstract: Self-tuning clusters for resilient microservices, including: receiving, by a services orchestrator within a cloud-computing environment and from a plurality of cloud computing instances, respective latency measurements corresponding to respective control plane operations directed to a shared resource of the plurality of cloud computing instances; determining, based on a current timeout value and on the respective latency measurements from the plurality of cloud computing instances, an updated timeout value for the shared resource; and providing, to each of the plurality of cloud computing instances, the updated timeout value for the shared resource.

Abstract: A method may include detecting, by a computing device based on a problem signature, that a system has experienced a problem that is associated with the problem signature, wherein the problem signature comprises a specification of a pattern of events indicative of the particular problem experienced by at least one other system; determining that the particular problem violates an operational policy of the system; and deploying, without user intervention, one or more corrective measures that modify the system to resolve the problem.

Abstract: An illustrative method includes detecting, by a cloud based storage system services provider based on a problem signature, that a storage system has experienced a problem that is associated with the problem signature; and deploying, without user intervention, one or more corrective measures that modify the storage system to resolve the problem.