Abstract: The present invention features a nucleic acid and a polypeptide encoding a novel splice variant isoform of mitotic centromere-associated kinesin (MCAK). The polynucleotide sequence of MCAKsv1 is provided by SEQ ID NO 2. The amino acid sequence for MCAKsv1 is provided by SEQ ID NO 3. The present invention also provides methods for using MCAKsv1 polynucleotide and protein to screen for compounds that bind to MCAKsv1 and to screen for compounds that bind to other kinesin isoform polypeptides but not to MCAKsv1.

Abstract: The present invention features nucleic acids and polypeptides encoding three novel splice variant isoforms of sodium channel, voltage gated, type VIII, alpha (SCN8A). The polynucleotide sequences of SCN8Asv1.1, SCN8Asv1.2 and SCN8Asv2 are provided by SEQ ID NO 3, SEQ ID NO 5, and SEQ ID NO 7, respectively. The amino acid sequences for SCN8Asv1.1, SCN8Asv1.2, and SCN8Asv2 are provided by SEQ ID NO 4, SEQ ID NO 6, and SEQ ID NO 8, respectively. The present invention also provides methods for using SCN8Asv1.1, SCN8Asv1.2, and SCN8Asv2 polynucleotides and proteins to screen for compounds that bind to SCN8Asv1.1, SCN8Asv1.2, and SCN8Asv2, respectively.

Abstract: The present invention features nucleic acids and polypeptides encoding three novel splice variant isoforms of receptor-interacting serine-threonine kinase 2 (RIPK2). The polynucleotide sequences of RIPK2sv1.1, RIPK2sv1.2, and RIPK2s2 are provided by SEQ ID NO 1, SEQ ID NO 3, and SEQ ID NO 5, respectively. The amino acid sequences for RIPK2sv1.1, RIPK2sv1.2, and RIPK2sv2 are provided by SEQ ID NO 2, SEQ ID NO 4, and SEQ ID NO 6, respectively. The present invention also provides methods for using RIPK2sv1.1, RIPK2sv1.2, and RIPK2sv2 polynucleotides and proteins to screen for compounds that bind to RIPK2sv1.1, RIPK2sv1.2, and RIPK2sv2, respectively.

Abstract: The present invention features nucleic acids and polypeptides encoding three novel variant isoform of centromere protein E (CENPE). The polynucleotide sequence of CENPEv2, CENPEv3, and CENPEv4 are provided by SEQ ID NO 6, SEQ ID NO 8, and SEQ ID NO 10, respectively. The amino acid sequences for CENPEv2, CENPEv3, and CENPEv4 are provided by SEQ ID NO 7, SEQ ID NO 9, and SEQ ID NO 11, respectively. The present invention also provides methods for using CENPEv2, CENPEv3, and CENPEv4 polynucleotides and proteins to screen for compounds that bind to CENPEv2, CENPEv3, and CENPEv4, respectively. The present invention also provides for methods to detect the presence of cancer and for inhibiting abnormal cell proliferation.