Abstract: This invention relates to various methods and systems of using therapeutic hypothermia to treat medical conditions such as cardiac arrest, myocardial ischemia, cerebral ischemia, ischemia, stroke, traumatic brain or spinal cord injuries and hypoxic-ischemic injury.

Abstract: This invention relates to various methods and systems of using therapeutic hypothermia to treat medical conditions such as cardiac arrest, myocardial ischemia, cerebral ischemia, ischemia, stroke, traumatic brain or spinal cord injuries and hypoxic-ischemic injury.

Abstract: Ultrashort laser pulses are used to induce photodisruptive breakdown in vasculature in an animal to controllably produce hemorrhage, thrombosis or breach of blood-brain barrier in individual, specifically targeted blood vessels. Damage is limited to the targeted vessels such that neighboring vessels exhibit no signs of vascular damage, including vessels directly above or below the targeted vessel. Ultrashort laser pulses of lower energy are also used to observe and quantify the baseline and altered states of blood flow. Observation and measurement may be performed (1) by TPLSM, OCT or other known techniques, providing a real-time, in vivo model for the dynamics and effects of vascular injury.

Abstract: Ultrashort laser pulses are used to induce photodisruptive breakdown in vasculature in an animal to controllably produce hemorrhage, thrombosis or breach of the blood-brain barrier in individual, specifically-targeted blood vessels. Damage is limited to the targeted vessels such that neighboring vessels exhibit no signs of vascular damage, including vessels directly above and directly below the targeted vessel. Ultrashort laser pulses of lower energy are also used to observe and quantify the baseline and altered states of blood flow. Observation and measurement may be performed by TPLSM, OCT or other known techniques, providing a real-time, in vivo model for the dynamics and effects of vascular injury.