Patents by Inventor Patrick M. Gillevet
Patrick M. Gillevet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11253554Abstract: Disclosed herein are compositions and methods for diagnosing fungal dysbiosis in the gut of a subject with cirrhosis that involves assaying a sample from the subject for bacterial taxa. These compositions and methods are based on the discovery that there is significant correlation between fungal and bacterial diversity in gut microbiota of cirrhotic patients. Therefore, disclosed herein is a method for treating a subject with liver cirrhosis that involves assaying a gut sample from the subject for bacterial taxa to generate a bacterial profile, comparing the bacterial profile to control profiles to predict fungal dysbiosis; and treating the subject for fungal dysbiosis.Type: GrantFiled: October 5, 2017Date of Patent: February 22, 2022Assignees: Virginia Commonwealth University, George Mason UniversityInventors: Jasmohan Bajaj, Patrick M. Gillevet
-
Patent number: 11091813Abstract: Embodiments of the invention herein described relate to multiplex polynucleotide sequence analysis without the use of size separation methods or blotting. In certain particulars the invention relates to multiplex sequencing using massively parallel sequencing methods, such as pyrosequencing methods and sequencing by synthesis. The invention provides increased throughput, increased accuracy of enumerating sample components, and the ability to analyze greater numbers of samples simultaneously or serially on presently available systems, as well as others yet to be developed. In certain of its embodiments the invention relates to the analysis of complex microbial communities, particularly to in-depth analysis thereof in large numbers of samples.Type: GrantFiled: August 18, 2016Date of Patent: August 17, 2021Assignee: PRESCIENT METABIOMICS JV, LLCInventor: Patrick M. Gillevet
-
Publication number: 20200157609Abstract: Methods of detecting and treating cognitive impairment are provided. The methods involve determining, via a metagenomic analysis, the salivary and/or gut microbiota signature of the subject, e.g. a subject with an illness such as chronic liver disease and/or post-traumatic stress disorder (PTSD), and based in the microbiota signature, identifying subjects who have cognitive impairment.Type: ApplicationFiled: October 22, 2019Publication date: May 21, 2020Inventors: Jasmohan Bajaj, Patrick M. Gillevet
-
Publication number: 20190224252Abstract: Disclosed herein are compositions and methods for diagnosing fungal dysbiosis in the gut of a subject with cirrhosis that involves assaying a sample from the subject for bacterial taxa. These compositions and methods are based on the discovery that there is significant correlation between fungal and bacterial diversity in gut microbiota of cirrhotic patients. Therefore, disclosed herein is a method for treating a subject with liver cirrhosis that involves assaying a gut sample from the subject for bacterial taxa to generate a bacterial profile, comparing the bacterial profile to control profiles to predict fungal dysbiosis; and treating the subject for fungal dysbiosis.Type: ApplicationFiled: October 5, 2017Publication date: July 25, 2019Inventors: Jasmohan Bajaj, Patrick M. Gillevet
-
Publication number: 20190194727Abstract: Embodiments of the invention herein described relate to multiplex polynucleotide sequence analysis without the use of size separation methods or blotting. In certain particulars the invention relates to multiplex sequencing using massively parallel sequencing methods, such as pyrosequencing methods and sequencing by synthesis. The invention provides increased throughput, increased accuracy of enumerating sample components, and the ability to analyze greater numbers of samples simultaneously or serially on presently available systems, as well as others yet to be developed. In certain of its embodiments the invention relates to the analysis of complex microbial communities, particularly to in-depth analysis thereof in large numbers of samples.Type: ApplicationFiled: February 1, 2019Publication date: June 27, 2019Inventor: Patrick M. Gillevet
-
Publication number: 20180251820Abstract: The present invention relates to methods and compositions for diagnosing, monitoring, prognosticating, analyzing, etc., polymicrobial diseases. The present invention also relates to the microbial community present in the digestive tract and lumen in normal subjects, and subjects with digestive tract diseases, especially diseases of the colon, such as inflammatory bowel disease, including ulcerative colitis, Crohn's syndrome, and pouchitis. The present invention especially relates to compositions and methods for diagnosing and prognosticating the mentioned diseases and conditions, e.g., to determine the presence of the disease in a subject, to determine a therapeutic regimen, to determine the onset of active disease, to determine the predisposition to the disease, etc.Type: ApplicationFiled: May 18, 2018Publication date: September 6, 2018Inventors: Patrick M. Gillevet, Ali Keshavarzian
-
Publication number: 20160355874Abstract: Embodiments of the invention herein described relate to multiplex polynucleotide sequence analysis without the use of size separation methods or blotting. In certain particulars the invention relates to multiplex sequencing using massively parallel sequencing methods, such as pyrosequencing methods and sequencing by synthesis. The invention provides increased throughput, increased accuracy of enumerating sample components, and the ability to analyze greater numbers of samples simultaneously or serially on presently available systems, as well as others yet to be developed. In certain of its embodiments the invention relates to the analysis of complex microbial communities, particularly to in-depth analysis thereof in large numbers of samples.Type: ApplicationFiled: August 18, 2016Publication date: December 8, 2016Inventor: Patrick M. Gillevet
-
Patent number: 9453262Abstract: Embodiments of the invention herein described relate to multiplex polynucleotide sequence analysis without the use of size separation methods or blotting. In certain particulars the invention relates to multiplex sequencing using massively parallel sequencing methods, such as pyrosequencing methods and sequencing by synthesis. The invention provides increased throughput, increased accuracy of enumerating sample components, and the ability to analyze greater numbers of samples simultaneously or serially on presently available systems, as well as others yet to be developed. In certain of its embodiments the invention relates to the analysis of complex microbial communities, particularly to in-depth analysis thereof in large numbers of samples.Type: GrantFiled: October 30, 2013Date of Patent: September 27, 2016Assignee: BIOSPHEREX, LLCInventor: Patrick M. Gillevet
-
Publication number: 20150267250Abstract: The present invention relates to methods and compositions for diagnosing, monitoring, prognosticating, analyzing, etc., polymicrobial diseases. The present invention also relates to the microbial community present in the digestive tract and lumen in normal subjects, and subjects with digestive tract diseases, especially diseases of the colon, such as inflammatory bowel disease, including ulcerative colitis, Crohn's syndrome, and pouchitis. The present invention especially relates to compositions and methods for diagnosing and prognosticating the mentioned diseases and conditions, e.g., to determine the presence of the disease in a subject, to determine a therapeutic regimen, to determine the onset of active disease, to determine the predisposition to the disease, etc.Type: ApplicationFiled: June 5, 2015Publication date: September 24, 2015Inventors: Patrick M. Gillevet, Ali Keshavarzian
-
Publication number: 20140194323Abstract: Embodiments of the invention herein described relate to multiplex polynucleotide sequence analysis without the use of size separation methods or blotting. In certain particulars the invention relates to multiplex sequencing using massively parallel sequencing methods, such as pyrosequencing methods and sequencing by synthesis. The invention provides increased throughput, increased accuracy of enumerating sample components, and the ability to analyze greater numbers of samples simultaneously or serially on presently available systems, as well as others yet to be developed. In certain of its embodiments the invention relates to the analysis of complex microbial communities, particularly to in-depth analysis thereof in large numbers of samples.Type: ApplicationFiled: October 30, 2013Publication date: July 10, 2014Applicant: BioSpherex, LLC a Limited Liability CompanyInventor: Patrick M. Gillevet
-
Publication number: 20140179537Abstract: The present invention relates to methods and compositions for diagnosing, monitoring, prognosticating, analyzing, etc., polymicrobial diseases. The present invention also relates to the microbial community present in the digestive tract and lumen in normal subjects, and subjects with digestive tract diseases, especially diseases of the colon, such as inflammatory bowel disease, including ulcerative colitis, Crohn's syndrome, and pouchitis. The present invention especially relates to compositions and methods for diagnosing and prognosticating the mentioned diseases and conditions, e.g., to determine the presence of the disease in a subject, to determine a therapeutic regimen, to determine a therapeutic regimen, to determine the onset of active disease, to determine the predisposition to the disease, etc.Type: ApplicationFiled: November 25, 2013Publication date: June 26, 2014Applicants: Rush University, George Mason Intellectual Properties, Inc.Inventor: Patrick M. Gillevet
-
Publication number: 20140179726Abstract: A systems biology approach is used to characterize and relate the intestinal (gut) microbiome of a host organism (e.g. a human) to physiological processes within the host. Information regarding the types and relative amounts of gut microflora is correlated with physiological processes indicative of e.g., a patient's risk of developing a disease or condition, likelihood of responding to a particular treatment, for adjusting treatment protocols, etc. The information is also used to identify novel suitable therapeutic targets and/or to develop and monitor the outcome of therapeutic treatments. An exemplary disease/condition is the development of hepatic encephalopathy (HE), particularly in patients with liver cirrhosis.Type: ApplicationFiled: May 18, 2012Publication date: June 26, 2014Applicants: VIRGINIA COMMONWEALTH UNIVERSITY, GEORGE MASON UNIVERSITY, THE U.S DEPARTMENT OF VETRANS AFFAIRSInventors: Jasmohan Bajaj, Arun Sanyal, Patrick M. Gillevet
-
Patent number: 8603749Abstract: Embodiments of the invention herein described relate to multiplex polynucleotide sequence analysis without the use of size separation methods or blotting. In certain particulars the invention relates to multiplex sequencing using massively parallel sequencing methods, such as pyrosequencing methods and sequencing by synthesis. The invention provides increased throughput, increased accuracy of enumerating sample components, and the ability to analyze greater numbers of samples simultaneously or serially on presently available systems, as well as others yet to be developed. In certain of its embodiments the invention relates to the analysis of complex microbial communities, particularly to in-depth analysis thereof in large numbers of samples.Type: GrantFiled: November 15, 2007Date of Patent: December 10, 2013Assignee: Biospherex, LLCInventor: Patrick M. Gillevet
-
Publication number: 20100143908Abstract: Embodiments of the invention herein described relate to multiplex polynucleotide sequence analysis without the use of size separation methods or blotting. In certain particulars the invention relates to multiplex sequencing using massively parallel sequencing methods, such as pyrosequencing methods and sequencing by synthesis. The invention provides increased throughput, increased accuracy of enumerating sample components, and the ability to analyze greater numbers of samples simultaneously or serially on presently available systems, as well as others yet to be developed. In certain of its embodiments the invention relates to the analysis of complex microbial communities, particularly to in-depth analysis thereof in large numbers of samples.Type: ApplicationFiled: November 15, 2007Publication date: June 10, 2010Applicant: BioSpherex, LLC, A Limited Liability CompanyInventor: Patrick M. Gillevet