Abstract: The present invention features nucleic acids and polypeptides encoding two novel splice variant isoforms of cysteine protease cathepsin K (CTSK). The polynucleotide sequences of CTSKsv1.1 and CTSKsv1.2 are provided by SEQ ID NO 1 and SEQ ID NO 3, respectively. The amino acid sequences for CTSKsv1.1 and CTSKsv1.2 are provided by SEQ ID NO 2 and SEQ ID NO 4, respectively. The present invention also provides methods for using CTSKsv1.1 and CTSKsv1.2 polynucleotides and proteins to screen for compounds that bind to CTSKsv1.1 and CTSKsv1.2, respectively.

Abstract: The present invention features nucleic acids and polypeptides encoding four novel splice variant isoforms of histone deacetylase 3 (HDAC3). The polynucleotide sequences of HDAC3sv1.1, HDAC3sv1.2, HDAC3sv2, HDAC3sv3, HDAC3sv4, HDAC3sv5, and HDAC3sv6 are provided by SEQ ID NO 1, SEQ ID NO 3, SEQ ID NO 5, SEQ ID NO 7, SEQ ID NO 9, SEQ ID NO 20, and SEQ ID NO 21, respectively. The amino acid sequences for HDAC3sv1.1, HDAC3sv1.2, HDAC3sv2, HDAC3sv3, and HDAC3sv4 are provided by SEQ ID NO 2, SEQ ID NO 4, SEQ ID NO 6, SEQ ID NO 8, and SEQ ID NO 10, respectively. The present invention also provides methods for using HDAC3sv1.1, HDAC3sv1.2, HDAC3sv2, HDAC3sv3, and HDAC3sv4 polynucleotides and proteins to screen for compounds that bind to HDAC3sv1.1, HDAC3sv1.2, HDAC3sv2, HDAC3sv3, or HDAC3sv4, respectively.