Abstract: The present invention relates to efficient synthetic processes useful in the preparation of antiviral nucleosides, particularly uridine 4-oxime 5?-(2-methylpropanoate) {(2R,3S,4R,5R)-3,4-dihydroxy-5-[4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl]oxolan-2-yl}methyl 2-methylpropanoate and pharmaceutically acceptable salts, derivatives, tautomers, isomers, and prodrugs of, which may be active as antiviral agents, as well as compositions and methods thereof. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

Abstract: A container for holding and pouring semi-viscous or viscous liquids is disclosed and is particularly useful for holding and pouring condiments such as ketchup, mayonnaise, mustard, relish or semi-viscous liquids such as salad dressing. The container includes an integrally molded body having a neck finish defining a generally cylindrical opening and being adapted to secure a lid to the container. At least one shaped pour guide is formed by the body below the neck finish for controlling and directing the flow of liquids out of the container in at least one selectable direction. In an embodiment, the container includes a plurality of shaped pour guides formed by the neck of the container and being spaced equidistantly about a circumference of the neck finish and opening of the container.

Abstract: An improved cell separator is provided that includes apparatus for automatically controlling the cell separation process. Particularly, a plurality of valves are responsive to a data processor assembly for controlling the path of fluid flow through the cell separator. A plurality of sensors are provided for providing sensor signals indicative of the density of fluid flowing through the cell separator. The microprocessor is responsive to the sensor signals for controlling the flow and operation of the cell separator. A parastaltic pump is responsive to the microprocessor assembly for controlling the speed and direction of fluid flow through the system. A stirplate assembly is responsive to a drive signal from the data processor assembly for controllably agitating the contents of a column. The data processor assembly is further responsive to the sensor input to provide the valve control signals and pump control signal to control the concentration of selected cells that are collected.

Abstract: A particle separator is provided for collection and manipulation of target particles, e.g., target cells, in a closed sterile field condition. In one embodiment, closed sterile field conditions are maintained from separation through concentration and/or cryo treatment steps and/or transfusion. Preservation of closed sterile field condition are accommodated by using the same integrally coupled rigid-walled vessel for collection and concentration and transfer via integrally coupled conduits to a vessel for cryopreservation and/or transfusion.In one embodiment, a plurality of valves are responsive to a data processor for controlling the path of fluid flow through the particle separator. A plurality of sensors are provided for providing sensor signals indicative of fluid flowing through the cell separator. A peristaltic pump is responsive to the microprocessor assembly for controlling the speed and direction of fluid flow through the system.

Abstract: A cell separator is provided that includes apparatus for automatically controlling the cell separation process. Particularly, a plurality of valves are responsive to a data processor assembly for controlling the path of fluid flow through the cell separator. A plurality of sensors are provided for providing sensor signals indicative of the density of fluid flowing through the cell separator. The microprocessor is responsive to the sensor signals for controlling the flow and operation of the cell separator. A parastaltic pump is responsive to the microprocessor assembly for controlling the speed and direction of fluid flow through the system. A stirplate assembly is responsive to a drive signal from the data processor assembly for controllably agitating the contents of a column. The data processor assembly is further responsive to the sensor input to provide the valve control signals and pump control signal to control the concentration of selected cells that are collected.

Abstract: A catheter sized and adapted to be passed through a tortuous path into a desired location in a human medical patient's body is disclosed. This catheter includes a deflection system, such as a bellows located at or near the distal end of the catheter. The distal end portion of the catheter can be controllably deflected, relative to the remainder of the catheter, by activating, e.g., pressurizing, the deflection system. This controlled deflection allows one to easily maneuver the catheter through the tortuous path.

Abstract: A device for use in withdrawing a catheter such as a balloon catheter from a vessel in the vascular system in order to inhibit damage to the vessel wall includes an assembly defining a passageway through which to pass the catheter. The assembly is dimensioned and arranged to be grasped by a user, and it includes components for coupling the assembly to the catheter so that the user can withdraw the catheter from the vessel by moving the assembly generally axially. The coupling components are adjustable to enable the user to select a desired maximum amount of force that can be coupled from the assembly to the catheter, and for this purpose one embodiment includes a cap-and-compressible-disk arrangement on a body member in which a spring-coupled handle member is telescopingly disposed, graduations along the handle member providing a visually discernible indication of relative handle member position and therefore of the magnitude of a force being coupled by the user to the assembly.

Abstract: An instrument comprising an elongated control handle having a passage extending therethrough, an elongated flexible catheter body having at least one lumen and a distal end coupled to the control handle and an elongated flexible member extending through the passage and into the lumen and having a distal end portion. A tool is coupled to the distal end portion of the flexible member, and the tool is capable of performing a medical task within a patient. An elongated flexible image-transmitting member extends through the passage of the control handle and into the lumen. A position controller is mounted for sliding movement along the control handle and is drivingly coupled to the flexible members so that the axial positions of the tool and the image-transmitting member can be adjusted with respect to the distal end of the catheter body.

Abstract: A tape-ribbon supply cartridge for supplying tape and ribbon to a lettering apparatus having a mechanism for creating a lettering force and a mechanism for positioning a character to be lettered into lettering position. The cartridge includes an improved ribbon rewind feature driven by movement of the tape advancement means and positioned in a common plane with the ribbon supply spool.

Abstract: A lettering apparatus adapted for receiving a replaceable tape supply cartridge comprising a pair of spaced apart, parallel frame members defining a cartridge receiving cavity and a print bar pivotally supported between the frame members. The apparatus also includes an improved force resisting arm.