Patents by Inventor Patrick M. McCarthy
Patrick M. McCarthy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220249231Abstract: An annuloplasty ring including elastic features that make the ring optimal for receiving a subsequent prosthetic valve via a “Valve In Ring Procedure.” The elastic features provide a squeezing force on the native valve annulus that both ensures coaptation of the native valve leaflets and also prevents paravalvular leakage around a subsequently-placed prosthetic valve.Type: ApplicationFiled: April 26, 2022Publication date: August 11, 2022Applicant: Northwestern UniversityInventor: Patrick M. McCarthy
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Patent number: 11337808Abstract: An annuloplasty ring including elastic features that make the ring optimal for receiving a subsequent prosthetic valve via a “Valve In Ring Procedure.” The elastic features provide a squeezing force on the native valve annulus that both ensures coaptation of the native valve leaflets and also prevents paravalvular leakage around a subsequently-placed prosthetic valve.Type: GrantFiled: June 8, 2016Date of Patent: May 24, 2022Assignee: Northwestern UniversityInventor: Patrick M. McCarthy
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Publication number: 20210113334Abstract: A ring sizer including a face plate that has markings usable to provide measurements of a valve. The sizer may include a clear face plate on which the markings are provided such that the valve is visible through the face plate facilitating accurate measurements of various valve dimensions and optimal ring sizing.Type: ApplicationFiled: June 11, 2019Publication date: April 22, 2021Applicant: Northwestern UniversityInventor: Patrick M. McCarthy
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Publication number: 20200390551Abstract: An annuloplasty device that includes at least one helical coil usable for percutaneous implantation and activatable such that a length of the coil shortens, thereby reducing a circumference of a dilated valve annulus.Type: ApplicationFiled: June 12, 2020Publication date: December 17, 2020Applicant: NORTHWESTERN UNIVERSITYInventor: Patrick M. McCarthy
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Publication number: 20190343631Abstract: An annuloplasty ring including a spring-like inner element that is able to be stretched to accept a prosthetic valve that, when stretched, places a circumferential constrictive force on the valve to prevent paravalvular leakage.Type: ApplicationFiled: May 24, 2019Publication date: November 14, 2019Applicant: Northwestern UniversityInventor: Patrick M. McCarthy
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Patent number: 10434225Abstract: The present invention provides single sheet and compound para-xylene films for therapeutic uses. For example, the present invention provides single sheet para-xylene films useful as tissue separators and/or adhesion barriers in a subject, where the top and/or bottom surfaces of such films have a water contact angle between 75 and 95 degrees (e.g., to prevent adhesion formation). The present invention also provides compound films composed of at least two para-xylene polymer films with a therapeutic molecule layer in between. Such compound films, when used in vivo (e.g., as a tissue separator and to treat inflammation or atrial fibrillation) allow either therapeutic molecule elution through one of the para-xylene layers, or therapeutic molecule release when the compound film is pierced, such as when it is sutured in place.Type: GrantFiled: March 29, 2016Date of Patent: October 8, 2019Assignees: Northwestern University, University of Maryland, Ann & Robert H. Lurie Children's Hospital of ChicagoInventors: Dean Ho, Erik M. Robinson, Sunjay Kaushal, Patrick M. McCarthy
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Publication number: 20190117398Abstract: Prosthetic annuloplasty ring(s) configured to attach to and remodel a valve annulus. Each ring can comprise a generally oval shaped inner body made of a semi-rigid material. The inner body can be surrounded by an outer suture-permeable sheath that permits the ring body to be attached to the valve annulus. The inner body can include a posterior section contiguous with an anterior section together forming a continuous periphery oriented about a flow axis. In plan view as seen along the flow axis, the ring can have a major axis perpendicular to a minor axis, wherein a maximum dimension lies along the major axis and a minimum dimension lies along the minor axis. The rings can be a set of rings of increasing ring sizes, where a ratio of the minimum dimension to the maximum dimension changes for at least some of the rings of different ring sizes.Type: ApplicationFiled: December 21, 2018Publication date: April 25, 2019Inventors: Ottavio Alfieri, Alain F. Carpentier, Francesco Maisano, Alberto Redaelli, Patrick M. McCarthy
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Patent number: 10188518Abstract: An annuloplasty ring having a three-dimensional discontinuous form generally arranged about an axis with two free ends that are axially offset. The ring is particularly suited for repair of the tricuspid valve, and more closely conforms to the annulus shape. The ring is more flexible in bending about radially extending axes than about the central axis. The ring may have an inner structural support covered by a pliable sleeve and/or a fabric tube. The structural support may have a varying cross-section, such as a C-shaped cross-section in a mid-section between two free ends and a rectangular cross-section at the free ends. A deliver template having a mounting ring with about the same shape as the ring facilitates implant, and may be releasably attached to a delivery handle. The deliver template may include a plurality of cutting guides for releasably attaching the annuloplasty ring thereto while presenting maximum outer surface area of the ring.Type: GrantFiled: August 15, 2016Date of Patent: January 29, 2019Assignee: Edwards Lifesciences CorporationInventors: Patrick M. McCarthy, Richard S. Rhee, Stefan Schreck
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Patent number: 10166101Abstract: Methods of remodeling an abnormal mitral valve with an annuloplasty ring having a reduced anterior-to-posterior dimension to restore coaptation between the mitral leaflets in mitral valve insufficiency (IMVI). The ring has a generally oval shaped body with a major axis perpendicular to a minor axis. An anterior section lies between anteriolateral and posteriomedial trigones, while a posterior section defines the remaining ring body and is divided into P1, P2, and P3 segments. The anterior-to-posterior dimension of the ring body is reduced from conventional rings; such as by providing, in atrial plan view, a pulled-in P3 segment. The ring body may have a downwardly deflected portion in the posterior section. The downwardly deflected portion may have an apex which is the lowest elevation of the ring body and may be offset with respect to the center of the downwardly deflected portion toward the P3 segment.Type: GrantFiled: June 22, 2016Date of Patent: January 1, 2019Assignee: Edwards Lifesciences CorporationInventors: Ottavio Alfieri, Alain F. Carpentier, Francesco Maisano, Alberto Redaelli, Patrick M. McCarthy
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Publication number: 20180168808Abstract: An annuloplasty ring including elastic features that make the ring optimal for receiving a subsequent prosthetic valve via a “Valve In Ring Procedure.” The elastic features provide a squeezing force on the native valve annulus that both ensures coaptation of the native valve leaflets and also prevents paravalvular leakage around a subsequently-placed prosthetic valve.Type: ApplicationFiled: June 8, 2016Publication date: June 21, 2018Applicant: Northwestern UniversityInventor: Patrick M. McCarthy
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Patent number: 9554787Abstract: The present invention provides methods and devices for obtaining percutaneous access, maintaining hemostasis, and providing closure of openings in tissues of the body. In particular, the present invention provides methods and devices for maintaining hemostasis and providing closure surgical incisions of the left ventricular apex of the heart.Type: GrantFiled: September 29, 2014Date of Patent: January 31, 2017Assignee: Northwestern UniversityInventors: Patrick M. McCarthy, Swaminadhan Gnanashanmugam, Usha Periyanayagam, Ingrid Lin, Leah Ralph, Christopher Lubeck
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Publication number: 20170000931Abstract: The present invention provides single sheet and compound para-xylene films for therapeutic uses. For example, the present invention provides single sheet para-xylene films useful as tissue separators and/or adhesion barriers in a subject, where the top and/or bottom surfaces of such films have a water contact angle between 75 and 95 degrees (e.g., to prevent adhesion formation). The present invention also provides compound films composed of at least two para-xylene polymer films with a therapeutic molecule layer in between. Such compound films, when used in vivo (e.g., as a tissue separator and to treat inflammation or atrial fibrillation) allow either therapeutic molecule elution through one of the para-xylene layers, or therapeutic molecule release when the compound film is pierced, such as when it is sutured in place.Type: ApplicationFiled: March 29, 2016Publication date: January 5, 2017Inventors: Dean Ho, Erik M. Robinson, Sunjay Kaushal, Patrick M. McCarthy
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Publication number: 20160367366Abstract: Methods of remodeling an abnormal mitral valve with an annuloplasty ring having a reduced anterior-to-posterior dimension to restore coaptation between the mitral leaflets in mitral valve insufficiency (IMVI). The ring has a generally oval shaped body with a major axis perpendicular to a minor axis. An anterior section lies between anteriolateral and posteriomedial trigones, while a posterior section defines the remaining ring body and is divided into P1, P2, and P3 segments. The anterior-to-posterior dimension of the ring body is reduced from conventional rings; such as by providing, in atrial plan view, a pulled-in P3 segment. The ring body may have a downwardly deflected portion in the posterior section. The downwardly deflected portion may have an apex which is the lowest elevation of the ring body and may be offset with respect to the center of the downwardly deflected portion toward the P3 segment.Type: ApplicationFiled: June 22, 2016Publication date: December 22, 2016Inventors: Ottavio Alfieri, Alain F. Carpentier, Francesco Maisano, Alberto Redaelli, Patrick M. McCarthy
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Publication number: 20160354206Abstract: An annuloplasty ring having a three-dimensional discontinuous form generally arranged about an axis with two free ends that are axially offset. The ring is particularly suited for repair of the tricuspid valve, and more closely conforms to the annulus shape. The ring is more flexible in bending about radially extending axes than about the central axis. The ring may have an inner structural support covered by a pliable sleeve and/or a fabric tube. The structural support may have a varying cross-section, such as a C-shaped cross-section in a mid-section between two free ends and a rectangular cross-section at the free ends. A deliver template having a mounting ring with about the same shape as the ring facilitates implant, and may be releasably attached to a delivery handle. The deliver template may include a plurality of cutting guides for releasably attaching the annuloplasty ring thereto while presenting maximum outer surface area of the ring.Type: ApplicationFiled: August 15, 2016Publication date: December 8, 2016Inventors: Patrick M. McCarthy, Richard S. Rhee, Stefan Schreck
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Patent number: 9414922Abstract: An annuloplasty ring having a three-dimensional discontinuous form generally arranged about an axis with two free ends that are axially offset. The ring is particularly suited for repair of the tricuspid valve, and more closely conforms to the annulus shape. The ring is more flexible in bending about radially extending axes than about the central axis. The ring may have an inner structural support covered by a pliable sleeve and/or a fabric tube. The structural support may have a varying cross-section, such as a C-shaped cross-section in a mid-section between two free ends and a rectangular cross-section at the free ends.Type: GrantFiled: February 9, 2012Date of Patent: August 16, 2016Assignee: Edwards Lifesciences CorporationInventors: Patrick M. McCarthy, Richard S. Rhee, Stefan Schreck
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Patent number: 9301927Abstract: The present invention provides single sheet and compound para-xylene films for therapeutic uses. For example, the present invention provides single sheet para-xylene films useful as tissue separators and/or adhesion barriers in a subject, where the top and/or bottom surfaces of such films have a water contact angle between 75 and 95 degrees (e.g., to prevent adhesion formation). The present invention also provides compound films composed of at least two para-xylene polymer films with a therapeutic molecule layer in between. Such compound films, when used in vivo (e.g., as a tissue separator and to treat inflammation or atrial fibrillation) allow either therapeutic molecule elution through one of the para-xylene layers, or therapeutic molecule release when the compound film is pierced, such as when it is sutured in place.Type: GrantFiled: May 21, 2014Date of Patent: April 5, 2016Assignees: Northwestern University, University of Maryland, Baltimore, Ann & Robert H. Lurie Children's Hospital of ChicagoInventors: Dean Ho, Erik M. Robinson, Sunjay Kaushal, Patrick M. McCarthy
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Patent number: 9149359Abstract: An annuloplasty ring having a three-dimensional discontinuous form generally arranged about an axis with two free ends that are axially offset. The ring is particularly suited for repair of the tricuspid valve, and more closely conforms to the annulus shape. The ring is more flexible in bending about radially extending axes than about the central axis. The ring may have an inner structural support covered by a pliable sleeve and/or a fabric tube. The structural support may have a varying cross-section, such as a C-shaped cross-section in a mid-section between two free ends and a rectangular cross-section at the free ends.Type: GrantFiled: February 9, 2012Date of Patent: October 6, 2015Assignee: Edwards Lifesciences CorporationInventors: Patrick M. McCarthy, Richard S. Rhee, Stefan Schreck
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Publication number: 20150230920Abstract: Methods of remodeling an abnormal mitral valve with an annuloplasty ring having a reduced anterior-to-posterior dimension to restore coaptation between the mitral leaflets in mitral valve insufficiency (IMVI). The ring has a generally oval shaped body with a major axis perpendicular to a minor axis. An anterior section lies between anteriolateral and posteriomedial trigones, while a posterior section defines the remaining ring body and is divided into P1, P2, and P3 segments. The anterior-to-posterior dimension of the ring body is reduced from conventional rings; such as by providing, in atrial plan view, a pulled-in P3 segment. The ring body may have a downwardly deflected portion in the posterior section. The downwardly deflected portion may have an apex which is the lowest elevation of the ring body and may be offset with respect to the center of the downwardly deflected portion toward the P3 segment.Type: ApplicationFiled: March 13, 2015Publication date: August 20, 2015Inventors: Ottavio Alfieri, Alain F. Carpentier, Francesco Maisano, Alberto Redaelli, Patrick M. McCarthy
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Publication number: 20150087916Abstract: The present invention provides methods and devices for obtaining percutaneous access, maintaining hemostasis, and providing closure of openings in tissues of the body. In particular, the present invention provides methods and devices for maintaining hemostasis and providing closure surgical incisions of the left ventricular apex of the heart.Type: ApplicationFiled: September 29, 2014Publication date: March 26, 2015Inventors: Patrick M. McCarthy, Swaminadhan Gnanashanmugam, Usha Periyanayagam, Ingrid Lin, Leah Ralph, Christopher Lubeck
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Publication number: 20140348895Abstract: The present invention provides single sheet and compound para-xylene films for therapeutic uses. For example, the present invention provides single sheet para-xylene films useful as tissue separators and/or adhesion barriers in a subject, where the top and/or bottom surfaces of such films have a water contact angle between 75 and 95 degrees (e.g., to prevent adhesion formation). The present invention also provides compound films composed of at least two para-xylene polymer films with a therapeutic molecule layer in between. Such compound films, when used in vivo (e.g., as a tissue separator and to treat inflammation or atrial fibrillation) allow either therapeutic molecule elution through one of the para-xylene layers, or therapeutic molecule release when the compound film is pierced, such as when it is sutured in place.Type: ApplicationFiled: May 21, 2014Publication date: November 27, 2014Applicant: Northwestern UniversityInventors: Dean Ho, Erik M. Robinson, Sunjay Kaushal, Patrick M. McCarthy