Patents by Inventor Patrick M. Woster

Patrick M. Woster has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor in grapefruit
    Patent number: 6160006
    Abstract: The present invention provides a composition and methods for inhibiting cytochrome P450 enzyme activity and in particular, inhibiting the activity of the cytochrome P450 3A sub-family of enzymes, specifically, CYP3A4. The present invention provides 6',7'-dihydroxybergamottin, a furanocoumarin, as the compound primarily responsible for the inhibitory effects of grapefruit juice on cytochrome P450 enzyme activity. The present invention also provides a novel synthesis scheme for 6',7'-dihydroxybergamottin.
    Type: Grant
    Filed: October 16, 1997
    Date of Patent: December 12, 2000
    Assignee: Wayne State University
    Inventors: David J. Edwards, Patrick M. Woster