Abstract: A vehicle seating assembly includes a seat, a front leg, a seatback, and a lower leg support. The seat includes a forward end and a rearward end. The seat is configured to be coupled to a support surface. The front leg engages with the support surface. The seatback is rotatably coupled to the seat proximate the rearward end. The lower leg support is directly and rotatably coupled to the seat proximate the forward end. The lower leg support is movable between an extended position and a retracted position. The vehicle seating assembly is movable between a seated position and a reclined-and-raised position. Moving from the seated position toward the reclined-and-raised position includes increasing a first distance between the front leg and the support surface.

Abstract: A transportation system is disclosed. The transportation system includes a vehicle, a plurality of seating assemblies positioned within a passenger compartment of the vehicle and defining an arrangement, a plurality of actuators that effect movement of various components of the plurality of seating assemblies, a plurality of sensors, and a controller. Specific examples of pre-set or pre-programmed arrangements are disclosed, as well as the ability to customize the arrangement. Additionally, exemplary methods are disclosed that illustrate transitions between a variety of the pre-set or pre-programmed arrangements.

Abstract: Provided herein are agonists of the apelin receptor for the treatment of disease. The compounds disclosed herein are useful for the treatment of a range of cardiovascular, renal and metabolic conditions.

Abstract: A communication system and associated methods are provided. The communication system and associated methods includes a vehicle having an interior for seating a number of individuals, a camera coupled to the interior, and a display screen coupled to the interior. The communication system further includes an apparatus having a camera and a display screen. The camera of the vehicle is wirelessly connected to the display screen of the apparatus. The camera of the apparatus is wirelessly connected to the display screen of the vehicle.

Abstract: A profile for an occupant is stored. The profile includes a plurality of clusters of sitting positions for the occupant in a seat and classifications of respective clusters as preferred or nonpreferred. Respective clusters are classified as preferred or nonpreferred based on sitting scores for the respective sitting positions in that cluster. A higher sitting score increases a likelihood of the classification being preferred. A series of pressure maps indicating a respective series of sitting positions of the occupant in the seat are received. The pressure maps include a current pressure map. One of the sitting positions is assigned to one of the clusters that is classified as preferred in response to the sitting score of that sitting position being greater than a threshold score. A physical configuration of the seat is adjusted in response to the current sitting position being in one of the clusters that is classified as nonpreferred.

Abstract: Provided herein are agonists of the apelin receptor of Formula (I): for the treatment of disease. The compounds disclosed herein are useful for the treatment of a range of cardiovascular, renal and metabolic conditions.

Abstract: Various embodiments relate to compounds and methods useful for preventing or treating a cancer in a subject. The method may include administering to a subject a composition according to any of the embodiments described herein in an amount effective to inhibit metastatic activity or tumor growth in the subject.

Abstract: A system for reconfiguring a seating assembly within a vehicle, the system comprising identifying an adjacent surface within an interior of the vehicle, calculating a distance between the seating assembly and the adjacent surface, wherein the configuration is an occupiable seating configuration, and further wherein the occupiable seating configuration has a mode chosen from a forward facing mode and a rearward facing mode, storing the distance between the seating assembly and the adjacent surface, receiving a user input to transition the seating assembly from one occupiable seating configuration mode chosen from the forward facing mode and the rearward facing mode toward the other mode, and controlling the configuration of the seating assembly to transition from one occupiable seating configuration mode chosen from the forward facing mode and the rearward facing mode toward the other of the forward facing mode and the rearward facing mode.

Abstract: A seat assembly includes a cushioned component having a lattice matrix. An air bladder assembly is covered by the lattice matrix. The air bladder assembly includes a plurality of air bladders supported on a platform assembly. Each air bladder includes a body portion operable between deflated and inflated conditions. Each air bladder includes a connection stem. A support plate includes a plurality of access apertures disposed therethrough. The air bladder assembly is operably coupled to the support plate. Each air bladder is aligned with at least one access aperture of the plurality of access apertures. A carrier assembly includes a plurality of mounting apertures disposed through an outer surface thereof. The carrier assembly receives the connection stem of each air bladder through at least one mounting aperture of the plurality of mounting apertures of the carrier assembly.

Abstract: A headrest assembly includes a lattice matrix having a plurality of three-dimensional (3D) cells. Each 3D cell of includes a node and a plurality of links outwardly extending from the node. The lattice matrix includes a plurality of sections including a first section having a first overall elastic modulus, a second section positioned adjacent to the first section and having a second overall elastic modulus that is higher than the first overall elastic modulus of the first section, and a third section positioned adjacent to the second section and having a third overall elastic modulus that is higher than the second overall elastic modulus of the second section. The lattice matrix is integrally constructed using an additive manufacturing technique, wherein the 3D cells of each section are provided in various patterns and cured to varying degrees to provide the varying overall elastic moduli of each section of the lattice matrix.

Abstract: A seat assembly includes a cushioned component having a lattice matrix. An air bladder assembly is covered by the lattice matrix. The air bladder assembly includes a plurality of air bladders supported on a platform assembly. Each air bladder includes a body portion operable between deflated and inflated conditions. Each air bladder includes a connection stem. A support plate includes a plurality of access apertures disposed therethrough. The air bladder assembly is operably coupled to the support plate. Each air bladder is aligned with at least one access aperture of the plurality of access apertures. A carrier assembly includes a plurality of mounting apertures disposed through an outer surface thereof. The carrier assembly receives the connection stem of each air bladder through at least one mounting aperture of the plurality of mounting apertures of the carrier assembly.

Abstract: Various embodiments relate to compounds and methods useful for preventing or treating a cancer in a subject. The method may include administering to a subject a composition according to any of the embodiments described herein in an amount effective to inhibit metastatic activity or tumor growth in the subject.

Abstract: A method of making a trim article includes the steps of 1) obtaining specified criteria of a target component part comprised of a plurality of materials; 2) processing the specified criteria into a design envelope that includes parameters of the target component part within which the trim article to be created is to be confined, 3) inputting the design envelope into an additive manufacturing device supplied with a single forming material; and 4) forming the trim article using the additive manufacturing device from the single material. The formed trim article includes an outer casing with an interior portion having one or more lattice matrices disposed therein and having varying density profiles to simulate the specified criteria of the target component part. The formed trim article is created as a fully integrated monolithic whole via the additive manufacturing device.

Abstract: A translation assembly for a vehicle includes a rail assembly that defines a first channel, a second channel, and a central member that extends between the first and second channels. A carriage assembly couples to the rail assembly. The carriage assembly is movable relative to the rail assembly. The carriage assembly includes a first rail engagement structure that extends into the rail assembly and is received within the first channel; a second rail engagement structure that extends into the rail assembly and is received within the second channel; and a carriage housing that is coupled to the first and second rail engagement structures. The carriage housing extends between the first and second rail engagement structures. The carriages assembly also includes one or more drive assemblies that engage with a top surface of the central member of the rail assembly.

Abstract: A transportation system is disclosed. The transportation system includes a vehicle, a plurality of seating assemblies positioned within a passenger compartment of the vehicle and defining an arrangement, a plurality of actuators that effect movement of various components of the plurality of seating assemblies, a plurality of sensors, and a controller. Specific examples of pre-set or pre-programmed arrangements are disclosed, as well as the ability to customize the arrangement. Additionally, exemplary methods are disclosed that illustrate transitions between a variety of the pre-set or pre-programmed arrangements.

Abstract: A vehicle seating assembly includes a seat, a front leg, a seatback, and a lower leg support. The seat includes a forward end and a rearward end. The seat is configured to be coupled to a support surface. The front leg engages with the support surface. The seatback is rotatably coupled to the seat proximate the rearward end. The lower leg support is directly and rotatably coupled to the seat proximate the forward end. The lower leg support is movable between an extended position and a retracted position. The vehicle seating assembly is movable between a seated position and a reclined-and-raised position. Moving from the seated position toward the reclined-and-raised position includes increasing a first distance between the front leg and the support surface.

Abstract: Provided herein are agonists of the apelin receptor for the treatment of disease. The compounds disclosed herein are useful for the treatment of a range of cardiovascular, renal and metabolic conditions.

Abstract: A seat assembly includes a cushioned component having a lattice matrix. An air bladder assembly is covered by the lattice matrix. The air bladder assembly includes a plurality of air bladders supported on a platform assembly. Each air bladder includes a body portion operable between deflated and inflated conditions. Each air bladder includes a connection stem. A support plate includes a plurality of access apertures disposed therethrough. The air bladder assembly is operably coupled to the support plate. Each air bladder is aligned with at least one access aperture of the plurality of access apertures. A carrier assembly includes a plurality of mounting apertures disposed through an outer surface thereof. The carrier assembly receives the connection stem of each air bladder through at least one mounting aperture of the plurality of mounting apertures. Each air bladder may include a release valve for releasing air therethrough.

Abstract: A vehicle seating assembly includes a seat, a support surface, a seatback and a lower leg support. The seat includes a forward end and a rearward end. The support surface is coupled to the seat. The seatback is rotatably coupled to the seat proximate the rearward end. The lower leg support is directly and rotatably coupled to the seat proximate the forward end. The lower leg support is directly coupled to the support surface in a manner that results in automatic mechanical deployment of the lower leg support when the seat and the seatback are moved toward a reclined-and-raised position.

Abstract: A transportation system includes a vehicle, a plurality of seating assemblies positioned within a passenger compartment of the vehicle and defining an arrangement, a plurality of actuators that effect movement of various components of the plurality of seating assemblies, a plurality of sensors, and a controller. Specific examples of pre-set or pre-programmed arrangements are provided, as well as the ability to customize the arrangement. Additionally, exemplary methods illustrate transitions between a variety of the pre-set or pre-programmed arrangements.