Patents by Inventor Patrick Maquaire

Patrick Maquaire has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12183475
    Abstract: An apparatus is for the automated production of a daughter radionuclide from a parent radionuclide using a generator comprising a solid medium onto which the parent nuclide is fixed and whereby the daughter nuclide is formed by radioactive decay of the parent nuclide. The apparatus includes a fluid circuit including a chromatography column having a head port and a tail port, at least one connection port for connecting the generator to the fluid circuit, at least one inlet port for connecting fluid sources to the fluid circuit and at least one valve controlled by an electronic control unit for selectively connecting the chromatography column, the connection port and the at least one inlet port in various configurations.
    Type: Grant
    Filed: November 3, 2020
    Date of Patent: December 31, 2024
    Assignee: Orano Med
    Inventors: Julien Torgue, Patrick Bourdet, Gilbert Andreoletti, Rémy Dureau, Patrick Maquaire
  • Patent number: 11037690
    Abstract: The invention relates to a method for preparing lead (212) for medical use. This method comprises the production of lead (212) by the decay of radium (224) in a generator comprising a solid medium to which the radium (224) is bound, followed by the extraction of the lead (212) from the generator in the form of an aqueous solution A1, characterised in that the lead (212) contained in the aqueous solution A1 is purified from the radiological and chemical impurities, also contained in said aqueous solution, by a liquid chromatography on a column. The invention also relates to an apparatus specially designed for automated implementation in a closed system of said method. It further relates to lead (212) produced by means of this method and this apparatus. Applications: manufacture of radiopharmaceuticals based on lead (212), useful in nuclear medicine for the treatment of cancers, particularly by a-radioimmunotherapy, or for medical imaging, in both humans and animals.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: June 15, 2021
    Assignee: ORANO MED
    Inventors: Julien Torgue, Patrick Maquaire, John Young, Gilbert Andreoletti, Patrick Bourdet
  • Publication number: 20210050126
    Abstract: An apparatus is for the automated production of a daughter radionuclide from a parent radionuclide using a generator comprising a solid medium onto which the parent nuclide is fixed and whereby the daughter nuclide is formed by radioactive decay of the parent nuclide. The apparatus includes a fluid circuit including a chromatography column having a head port and a tail port, at least one connection port for connecting the generator to the fluid circuit, at least one inlet port for connecting fluid sources to the fluid circuit and at least one valve controlled by an electronic control unit for selectively connecting the chromatography column, the connection port and the at least one inlet port in various configurations.
    Type: Application
    Filed: November 3, 2020
    Publication date: February 18, 2021
    Inventors: Julien TORGUE, Patrick BOURDET, Gilbert ANDREOLETTI, Rémy DUREAU, Patrick MAQUAIRE
  • Patent number: 10861615
    Abstract: A process for producing a daughter radionuclide from a parent radionuclide includes a) loading the parent radionuclide on a first solid medium contained in a generator and onto which the parent radionuclide is retained and whereby the daughter radionuclide is formed by radioactive decay of the parent radionuclide; b) eluting this medium with a A0 solution so as to recover a A1 solution comprising the daughter radionuclide; c) optionally adjusting the pH of the A1 solution so as to obtain a A1? solution, d) loading this A1 or A1? solution onto the head of a second solid medium contained in a chromatography column; e) first washing said second solid medium with a A2 solution; f) second washing said second solid medium with a A2? solution; g) eluting the daughter radionuclide with a A3 solution. The first washing step is conducted from head to tail of the column and the second washing step and the second eluting step are conducted from tail to head of the column.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: December 8, 2020
    Assignee: ORANO MED
    Inventors: Julien Torgue, Patrick Bourdet, Gilbert Andreoletti, Rémy Dureau, Patrick Maquaire
  • Publication number: 20180350480
    Abstract: The present invention concerns a process for producing a daughter radionuclide from a parent radionuclide comprising the purification of the daughter radionuclide on a chromatography column, as well as the apparatus for carrying out such process.
    Type: Application
    Filed: November 22, 2016
    Publication date: December 6, 2018
    Inventors: Julien TORGUE, Patrick BOURDET, Gilbert ANDREOLETTI, Rémy DUREAU, Patrick MAQUAIRE
  • Publication number: 20180308600
    Abstract: The invention relates to a method for preparing lead (212) for medical use. This method comprises the production of lead (212) by the decay of radium (224) in a generator comprising a solid medium to which the radium (224) is bound, followed by the extraction of the lead (212) from the generator in the form of an aqueous solution A1, characterised in that the lead (212) contained in the aqueous solution A1 is purified from the radiological and chemical impurities, also contained in said aqueous solution, by a liquid chromatography on a column. The invention also relates to an apparatus specially designed for automated implementation in a closed system of said method. It further relates to lead (212) produced by means of this method and this apparatus. Applications: manufacture of radiopharmaceuticals based on lead (212), useful in nuclear medicine for the treatment of cancers, particularly by a-radioimmunotherapy, or for medical imaging, in both humans and animals.
    Type: Application
    Filed: June 5, 2018
    Publication date: October 25, 2018
    Applicant: ORANO MED
    Inventors: Julien Torgue, Patrick Maquaire, John Young, Gilbert Andreoletti, Patrick Bourdet
  • Patent number: 10020086
    Abstract: The invention relates to a method for preparing lead (212) for medical use. This method comprises the production of lead (212) by the decay of radium (224) in a generator comprising a solid medium to which the radium (224) is bound, followed by the extraction of the lead (212) from the generator in the form of an aqueous solution A1, characterized in that the lead (212) contained in the aqueous solution A1 is purified from the radiological and chemical impurities, also contained in said aqueous solution, by a liquid chromatography on a column. The invention also relates to an apparatus specially designed for automated implementation in a closed system of said method. It further relates to lead (212) produced by means of this method and this apparatus. Applications: manufacture of radiopharmaceuticals based on lead (212), useful in nuclear medicine for the treatment of cancers, particularly by a-radioimmunotherapy, or for medical imaging, in both humans and animals.
    Type: Grant
    Filed: May 23, 2013
    Date of Patent: July 10, 2018
    Assignee: Orano Med
    Inventors: Julien Torgue, Patrick Maquaire, John Young, Gilbert Andreoletti, Patrick Bourdet
  • Publication number: 20150170776
    Abstract: The invention relates to a method for preparing lead (212) for medical use. This method comprises the production of lead (212) by the decay of radium (224) in a generator comprising a solid medium to which the radium (224) is bound, followed by the extraction of the lead (212) from the generator in the form of an aqueous solution A1, characterised in that the lead (212) contained in the aqueous solution A1 is purified from the radiological and chemical impurities, also contained in said aqueous solution, by a liquid chromatography on a column. The invention also relates to an apparatus specially designed for automated implementation in a closed system of said method. It further relates to lead (212) produced by means of this method and this apparatus. Applications: manufacture of radiopharmaceuticals based on lead (212), useful in nuclear medicine for the treatment of cancers, particularly by a-radioimmunotherapy, or for medical imaging, in both humans and animals.
    Type: Application
    Filed: May 23, 2013
    Publication date: June 18, 2015
    Applicant: AREVA MED SAS
    Inventors: Julien Torgue, Patrick Maquaire, John Young, Gilbert Andreoletti, Patrick Bourdet