Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for improving recommendation to users in data intelligence systems. In one aspect, a method includes the actions of receiving a current observation describing an interaction of a user with a data intelligence system; identifying a current user interest based on the current observation, wherein past observations of the user with the data intelligence system are clustered to form user interests in a Markov model; using the Markov model and based on the current user interest, determining a next user interest from the user interests; extracting a one past observation from the determined next user interest based on a selection criterion and a threshold, wherein the selection criterion is based on how closely the at least one past observation matches the current observation; and sending a recommendation to the user based on the past observation.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for improving recommendation to users in data intelligence systems. In one aspect, a method includes the actions of receiving a current observation describing an interaction of a user with a data intelligence system; identifying a current user interest based on the current observation, wherein past observations of the user with the data intelligence system are clustered to form user interests in a Markov model; using the Markov model and based on the current user interest, determining a next user interest from the user interests; extracting a one past observation from the determined next user interest based on a selection criterion and a threshold, wherein the selection criterion is based on how closely the at least one past observation matches the current observation; and sending a recommendation to the user based on the past observation.

Abstract: An optical amplifier for pulsed laser with short or ultra-short and energetic pulses includes an optical pumping source for generating a pump wave, an elongate amplifying medium including an input interface for receiving an optical signal to be amplified, the medium being able to amplify the optical signal propagating along the amplifying medium and to extract an amplified signal and an optical system for coupling the pump wave in the amplifying medium so as to pump the amplifying medium longitudinally. The amplifying medium has a minimum transverse dimension ?3 and the optical system focuses the pump wave inside the gain medium, the focused pump wave having a transverse dimension ?6 which is smaller than the dimension ?3 of the medium and a smaller numerical aperture than the numerical aperture of the medium, so that the pump wave propagates freely over a part of the amplifying medium and then in a confined manner over a part of the amplifying medium.

Abstract: A lithographic apparatus includes an illumination system configured to provide a first beam of radiation, which forms a first mask illumination region, and configured to substantially simultaneously provide a second beam of radiation, which forms a second mask illumination region. The first and second illumination regions being configured to substantially simultaneously illuminate a same mask. The lithographic apparatus also includes a projection system configured to project the first radiation beam such that it forms a first substrate illumination region and configured to simultaneously project the second radiation beam such that it forms a second substrate illumination region.

Abstract: The invention relates to a Switch connector for mounting on a printed circuit board, adapted to receive a mating connector in an insertion direction along an insertion axis. The switch connector comprises a shield, a contact element, and a contact spring having at least one fixed leg, at least one elastically deflectable switching leg, and at least one spring bend, the fixed leg and the switching leg extending from the spring bend in a common direction and passing the insertion axis. The switching leg is adapted to be moved by insertion of the mating connector from a rest position, at which the switching leg exerts a spring force onto the contact element, to a switching position, at which the switching leg is spaced apart from the contact element, at least one spring force flux that in the rest position is generated by the switching leg and guided in a closed loop to the fixed leg. To increase the reliability of the switching function, the shield is arranged in the closed loop of the spring force flux.

Abstract: A multi-stage compression installation is formed of a main pipe (2) emerging in a baffle plate (3), where at least two compressors (4, 5) are mounted in series each having its own drive member (9, 10). The installation is equipped with a system for determining the pressure at the output of the main pipe (2), the installation being connected to a control box (8). Typically, the control box (8) is connected to at least two of the drive members (9, 10) of the compressors (4, 5) and ensures monitoring of the compressors such that the latter rotate jointly whether charged or uncharged. Thus, the compressors (4, 5) are jointly charged based on the pressure prevailing in the baffle plate (3), such that the charging of the compressor representing the overpressure stage, the compressor(s) of the lower compression stages are automatically and jointly charged.

Abstract: A lithographic apparatus includes an illumination system configured to provide a first beam of radiation, which forms a first mask illumination region, and configured to substantially simultaneously provide a second beam of radiation, which forms a second mask illumination region. The first and second illumination regions being configured to substantially simultaneously illuminate a same mask. The lithographic apparatus also includes a projection system configured to project the first radiation beam such that it forms a first substrate illumination region and configured to simultaneously project the second radiation beam such that it forms a second substrate illumination region.

Abstract: The invention relates to a coaxial connector (1) for mounting on a printed circuit board adapted to receive a mating coaxial connector in an insertion direction (I). The coaxial connector comprises a contact spring (8) having a fixed leg (16) and an deflectable switching leg (15). The switching leg (15) is moved by insertion of the mating connector from a rest position to a switching position. In rest position said switching leg electrically conductively presses against the switch portion (19) of the contact element (10). The spring force flux (F) is guided via a contact element (10) in a closed loop back to the contact spring (8). In switching position the switching leg (15) is spaced apart in an switching direction (D) from the switch portion (19) by the inserted mating connector.

Abstract: An optical amplifier for pulsed laser with short or ultra-short and energetic pulses includes an optical pumping source for generating a pump wave, an elongate amplifying medium including an input interface for receiving an optical signal to be amplified, the medium being able to amplify the optical signal propagating along the amplifying medium and to extract an amplified signal and an optical system for coupling the pump wave in the amplifying medium so as to pump the amplifying medium longitudinally. The amplifying medium has a minimum transverse dimension ?3 and the optical system focuses the pump wave inside the gain medium, the focused pump wave having a transverse dimension ?6 which is smaller than the dimension ?3 of the medium and a smaller numerical aperture than the numerical aperture of the medium, so that the pump wave propagates freely over a part of the amplifying medium and then in a confined manner over a part of the amplifying medium.

Abstract: The present invention relates to a method of detecting and/or quantifying a target molecule from a sample obtained from a subject wherein the method comprises: (i) incubating a fusion protein or conjugate comprising a Ter binding polypeptide fused to at least one anti-target molecule or fragment thereof with a partially double-stranded oligonucleotide for a time and under conditions sufficient to bind to said Ter binding polypeptide thereby producing a complex; (ii) incubating said complex in the presence of said sample comprising said target molecule for a time and under conditions sufficient for said anti-target molecule to bind to said target molecule thereby producing a target-bound complex; (iii) incubating said target-bound complex in the presence of at least one immobilised molecule wherein said immobilised molecule has an affinity to said target molecule; (iv) incubating said immobilised molecule for a time and under conditions sufficient to bind to said target molecule thus immobilising said target m

Abstract: The invention relates to a coaxial connector (1) for mounting on a printed circuit board adapted to receive a mating coaxial connector in an insertion direction (I). The coaxial connector comprises a contact spring (8) having a fixed leg (16) and an deflectable switching leg (15). The switching leg (15) is moved by insertion of the mating connector from a rest position to a switching position. In rest position said switching leg electrically conductively presses against the switch portion (19) of the contact element (10). The spring force flux (F) is guided via a contact element (10) in a closed loop back to the contact spring (8). In switching position the switching leg (15) is spaced apart in an switching direction (D) from the switch portion (19) by the inserted mating connector.

Abstract: The invention relates to a Switch connector for mounting on a printed circuit board, adapted to receive a mating connector in an insertion direction along an insertion axis. The switch connector comprises a shield, a contact element, and a contact spring having at least one fixed leg, at least one elastically deflectable switching leg, and at least one spring bend, the fixed leg and the switching leg extending from the spring bend in a common direction and passing the insertion axis. The switching leg is adapted to be moved by insertion of the mating connector from a rest position, at which the switching leg exerts a spring force onto the contact element, to a switching position, at which the switching leg is spaced apart from the contact element, at least one spring force flux that in the rest position is generated by the switching leg and guided in a closed loop to the fixed leg. To increase the reliability of the switching function, the shield is arranged in the closed loop of the spring force flux.

Abstract: The invention concerns an installation for high pressure compression with several stages, normally used for producing PET bottles. The inventive installation comprises a main pipe (2) emerging in a baffle plate (3), wherein at least two compressors (4, 5) are mounted in series each having its own drive member (9, 10). The installation is equipped with means (7) for determining the pressure at the output of the main pipe (2), said installation being connected to a control box (8). Typically, the control box (8) is connected to at least two of the drive members (9, 10) of the compressors (4, 5) and ensures monitoring of said compressors such that the latter rotate jointly whether charged or uncharged. Thus, the compressors (4, 5) are jointly charged based on the pressure prevailing in the baffle plate (3), such that the charging of the compressor representing the overpressure stage, the compressor(s) of the lower compression stages are automatically and jointly charged.

Abstract: The present invention relates generally to the field of screening or diagnostic applications in which a target is required to be displayed for binding to another molecule, or interaction or reaction with another molecule. In particular, the present invention relates to the use of DNA/protein interactions to immobilize or present one or more biomolecules for screening purposes.

Abstract: The invention relates to a Microswitch connector (11), having an insulating housing (13) with a contact chamber (31) with an insertion opening (15) and a contact switch spring (25) arranged in the contact chamber (31). The housing (13) has an electrically conductive stop (59) on a side of the contact chamber (31) remote from the insertion opening (15) for making a first external electrical connection. The contact switch spring (25) has a spring bend connecting a fixed leg (37) to a switch leg (39). The fixed leg (37) is fixed in the housing (13) outside the insertion path of the plug-in contact with a connection end (45) for making a second external electrical connection, and the switch leg (39) extends obliquely into the insertion path in the direction of the stop (59) and pivotal resiliently relative to the fixed leg (37) with a free end (57) pre-tensioned to rest against the stop (59).

Abstract: Disclosed is a micro-plug and socket connector that is suitable for mounting on a printed circuit board and that has a plastic housing including a fastening surface with soldering portions for mounting on the surface of the printed circuit board, a plug receiving opening having an inner contact region for the receiving and contacting a pin contact, and an outer contact terminal. The inner contact region, the outer contact terminal, the soldering portions and the electrically conductive connections provided therebetween are formed of metallized portions on the plastic housing.

Abstract: A human metalloproteinase is described together with nucleic acids coding therefor and corresponding antisense DNA and RNA. The metalloproteinase may be used to generate antibodies therefor and to obtain compounds capable of regulating the action of the metalloproteinase in vivo.

Abstract: DNA sequences coding for a human metalloproteinase are described together with the corresponding antisense DNA and RNA. The DNA may be used to produce the metalloproteinase which may be used to generate antibodies thereto and to obtain other compounds capable of regulating the action of the metalloproteinase in vivo.