Patents by Inventor Patrick Martin Vaughan

Patrick Martin Vaughan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the characterization of nucleic acid molecules involving generation of extendible upstream DNA fragments resulting from the cleavage of nucleic acid at an abasic site
    Patent number: 7175982
    Abstract: The present invention is drawn to a method for characterising nucleic acid molecules, which comprises the steps of: i) introducing a modified base which is a substrate for a DNA glycosylase into a DNA molecule; ii) excising the modified base with the DNA glycosylase to generate an abasic site; iii) cleaving the DNA at the abasic site to generate and release an extendible upstream DNA fragment having a 3? hydroxyl terminus; and iv) incubating the released extendible upstream DNA fragment in the presence of an enzyme allowing for extension thereof and an additional template nucleic acid and analysing resultant fragment(s).
    Type: Grant
    Filed: April 22, 1998
    Date of Patent: February 13, 2007
    Assignees: Enterprise Ireland (T/A BioResearch Ireland), University College Cork Natl. University of Ireland
    Inventors: Thomas Valentine McCarthy, Patrick Martin Vaughan
  • Glycosylase mediated detection of nucleotide sequences at candidate loci
    Patent number: 5952176
    Abstract: A novel process is presented for the detection of known mutations and polymorphisms in DNA. This process, termed glycosylase mediated polymorphism detection (GMPD) involves amplification of the target DNA using three normal dNTPs and a fourth modified dNTP, whose base is a substrate for a specific DNA-glycosylase once incorporated into the DNA.
    Type: Grant
    Filed: January 8, 1998
    Date of Patent: September 14, 1999
    Assignee: FORFAS (Trading as Bioresearch Ireland)
    Inventors: Thomas Valentine McCarthy, Patrick Martin Vaughan