Abstract: The present application provides a recombinant binding protein that specifically binds to HDAC6 and blocks the ubiquitin-engaging zinc finger domain of HDAC6.

Abstract: In described examples, a storage cell ring includes circularly coupled storage cells. Each storage cell includes a respective capacitor for generating a respective integrated voltage responsive to a respective duration a respective storage cell is selected, a respective thresholding converter for generating a respective thresholded signal for indicating whether the respective integrated voltage has crossed a threshold, and respective selection circuitry configured to generate a respective select signal responsive to select signals generated by a respective adjacent storage cells. The ring is coupled to an analog quantifier for generating a conversion value responsive to the generated respective integrated voltage and a respective select signal. The ring is coupled to a loop counter for generating a loop count value responsive to changes of values of at least some of the respective thresholded signals. The conversion value and the loop count value can comprise a time measurement.

Abstract: Homozygouse knock-out mice lacking the Aiolos gene are shown to exhibit multiple phenotypes in common with humans suffering from the autoimmune disease Systemic Lupus Erythematosus (SLE). When Aiolos ?/? mice are crossed with homozygous knock out mice lacking the OBF-1 transcription factor gene, resultant double knock out mice lack all signs of SLE. Methods of screening for agents active against autoimmune diseases, for example SLE are provided. In vitro methods include screening for antagonists of OBF-1, screening for agents which inhibit binding of OBF-1 to oct-1 or oct-2, screening for agonists or antagonists of Aiolos protein and screening for agents which upregulate expression of Aiolos or downregulate expression of OBF-1. Also disclosed are methods of screening using knock-out mice and B cells from knock-out mice.