Patents by Inventor Patrick McHugh

Patrick McHugh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220352867
    Abstract: Acoustic resonators, filters, and methods. An acoustic resonator includes a substrate, piezoelectric plate, and a diaphragm comprising a portion of the piezoelectric plate spanning a cavity in a substrate. An interdigital transducer (IDT) on a front surface of the piezoelectric plate includes first and second sets of interleaved interdigital transducer (IDT) fingers extending from first and second busbars respectively. The interleaved IDT fingers are on the diaphragm. Overlapping portions of the interleaved IDT fingers define an aperture of the acoustic resonator. A first dielectric strip overlaps the IDT fingers in a first margin of the aperture and extends into a first gap between the first margin and the first busbar. A second dielectric strip overlaps the IDT fingers in a second margin of the aperture and extends into a second gap between the second margin and the second busbar.
    Type: Application
    Filed: December 3, 2021
    Publication date: November 3, 2022
    Inventors: John Pandelis Koulakis, Sean McHugh, Greg Dyer, Bryant Garcia, Filip ILIEV, Julius Koskela, Patrick Turner, Neal Fenzi
  • Publication number: 20220296723
    Abstract: The present invention provides a number of process improvements related to the conjugation of capsular polysaccharides from Streptococcus pneumoniae to a carrier protein. These process are serotype specific and include acid hydrolysis, addition of sodium chloride to the reductive amination reaction, and addition of sucrose to dissolve polysaccharides. Polysaccharide-protein conjugates prepared using the processes of the invention can be included in multivalent pneumococcal conjugate vaccines.
    Type: Application
    Filed: June 9, 2022
    Publication date: September 22, 2022
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Patrick McHugh, Michael Albert Winters, Janelle Konietzko
  • Patent number: 11400162
    Abstract: The present invention provides a number of process improvements related to the conjugation of capsular polysaccharides from Streptococcus pneumoniae to a carrier protein. These process are serotype specific and include acid hydrolysis, addition of sodium chloride to the reductive amination reaction, and addition of sucrose to dissolve polysaccharides. Polysaccharide-protein conjugates prepared using the processes of the invention can be included in multivalent pneumococcal conjugate vaccines.
    Type: Grant
    Filed: September 4, 2018
    Date of Patent: August 2, 2022
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Patrick McHugh, Janelle Konietzko
  • Publication number: 20220233674
    Abstract: The present invention provides a process improvement related to the conjugation of capsular polysaccharides from Streptococcus pneumoniae (S. pneumoniae) serotype 35B to a carrier protein. The serotype 35B polysaccharide-protein conjugate, prepared by the disclosed process, is, among other things, more immunogenic than similar conjugates made by prior art methods. S. pneumoniae serotype 35B polysaccharide-protein conjugates prepared using the processes of the invention can be included in multivalent pneumococcal conjugate vaccine compositions.
    Type: Application
    Filed: June 1, 2020
    Publication date: July 28, 2022
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Jian He, Patrick McHugh, Katherine M. Phillips, Adriana N. Santiago-Miranda
  • Patent number: 11381061
    Abstract: A system for servicing cable includes a field-end assembly and a live-end assembly, each mounted on a support structure having at least one drive mechanism operable to cause relative linear movement between the field-end assembly and the live-end assembly. A drilling-and-shorting assembly can create a short circuit in a field-end of the cable, and a continuity tester can test the integrity of the short-circuit. The field end of the cable can then be ejected from the system, and an end-cap-cradle assembly can position an end cap on a live end of an electrical cable and test its installation.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: July 5, 2022
    Assignees: ULC Technologies, LLC, Consolidated Edison Company of New York, Inc.
    Inventors: Alex Symington, Dennis John Semet, Caner Oktayer, Aalap Rajendra Shah, Than Lin Htaik, Patrick McHugh, Maggie Chow, George Murray, Luis Jerez, Thomas Campbell, Michael Baratta
  • Patent number: 11233484
    Abstract: Processes and systems for producing glass fibers having regions devoid of glass using submerged combustion melters, including feeding a vitrifiable feed material into a feed inlet of a melting zone of a melter vessel, and heating the vitrifiable material with at least one burner directing combustion products of an oxidant and a first fuel into the melting zone under a level of the molten material in the zone. One or more of the burners is configured to impart heat and turbulence to the molten material, producing a turbulent molten material comprising a plurality of bubbles suspended in the molten material, the bubbles comprising at least some of the combustion products, and optionally other gas species introduced by the burners. The molten material and bubbles are drawn through a bushing fluidly connected to a forehearth to produce a glass fiber comprising a plurality of interior regions substantially devoid of glass.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: January 25, 2022
    Assignee: Johns Manville
    Inventors: Mark William Charbonneau, Kevin Patrick McHugh
  • Publication number: 20210379174
    Abstract: The invention is related to multivalent immunogenic compositions comprising more than one S. pneumoniae polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an S. pneumoniae serotype conjugated to a carrier protein, wherein the serotypes of S. pneumoniae are as defined herein. In some embodiments, at least one of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. In further embodiments, each of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection against S. pneumoniae infection and diseases caused by S. pneumoniae.
    Type: Application
    Filed: July 13, 2021
    Publication date: December 9, 2021
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: William J. Smith, Patrick McHugh, Michael A. Winters, Julie M. Skinner, Jian He, Luwy Musey, Chitrananda Abeygunawardana, Yadong Adam Cui, Michael J. Kosinski
  • Publication number: 20210330777
    Abstract: The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from Streptococcus pneumoniae bacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.
    Type: Application
    Filed: July 7, 2021
    Publication date: October 28, 2021
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Jian He, John E. MacNair, William J. Smith, Michael A. Winters, Joseph G. Joyce, Chitrananda Abeygunawardana, Luwy Musey, Hari Pujar, Julie M. Skinner, Patrick McHugh
  • Patent number: 11116828
    Abstract: The invention is related to multivalent immunogenic compositions comprising more than one S. pneumoniae polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an S. pneumoniae serotype conjugated to a carrier protein, wherein the serotypes of S. pneumoniae are as defined herein. In some embodiments, at least one of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. In further embodiments, each of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection against S. pneumoniae infection and diseases caused by S. pneumoniae.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: September 14, 2021
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: William J. Smith, Patrick McHugh, Michael Albert Winters, Julie M. Skinner, Jian He, Luwy Musey, Chitrananda Abeygunawardana, Yadong Adam Cui, Michael J. Kosinski
  • Publication number: 20210252126
    Abstract: A method is described for reconstituting lyophilized mutant diphtheria toxin in dimethyl sulfoxide for use in producing pneumococcal capsular polysaccharide mutant diphtheria toxin conjugates.
    Type: Application
    Filed: April 25, 2019
    Publication date: August 19, 2021
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Patrick Leonard Ahl, Akhilesh Bhambhani, Christopher Jon Farrell, Patrick McHugh, Morrisa C. Jones, Daniel D. Roth, Jessica R. Sinacola, Justin Stanbro, Matthew P. Watson, Emily Wen, Michael A. Winters
  • Publication number: 20210252125
    Abstract: A method is described for producing a pneumococcal capsular polysaccharide protein conjugate in which one or more activated pneumococcal polysaccharides of particular pneumococcal serotypes and carrier protein are separately lyophilized, the separately lyophilized polysaccharides and carrier protein are separately reconstituted in an organic solvent, and the reconstituted polysaccharide and carrier protein are then combined together by Tee-mixing and conjugated together to produce polysaccharide carrier protein conjugates. A plurality of conjugates, each comprising polysaccharides of a particular serotype, may be used to produce multivalent pneumococcal immunogenic compositions having a combination of conjugates for use in vaccines.
    Type: Application
    Filed: April 25, 2019
    Publication date: August 19, 2021
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Patrick Leonard Ahl, Akhilesh Bhambhani, Christopher Jon Farrell, Patrick McHugh, Morrisa C. Jones, Daniel D. Roth, Jessica R. Sinacola, Justin Stanbro, Matthew P. Watson, Emily Wen, Michael A. Winters
  • Patent number: 11090374
    Abstract: The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from Streptococcus pneumoniae bacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: August 17, 2021
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Jian He, John E. MacNair, William J. Smith, Michael A. Winters, Joseph G. Joyce, Chitrananda Abeygunawardana, Luwy Musey, Hari Pujar, Julie M. Skinner, Emily Wen, Patrick McHugh, John Michael Williams, Catherine Lancaster
  • Publication number: 20210236646
    Abstract: A method is described for producing a pneumococcal capsular polysaccharide protein conjugate in which one or more activated pneumococcal polysaccharides of particular pneumococcal serotypes and carrier protein are separately lyophilized in the form of lyospheres of carrier protein and lyospheres of the one or more polysaccharides. A predetermined amount of carrier protein lyospheres and activated polysaccharide lyospheres are mixed together and the mixture reconstituted in an organic solvent to produce polysaccharide carrier protein conjugates. A plurality of conjugates, each comprising polysaccharides of a particular serotype, may be used to produce multivalent pneumococcal immunogenic compositions having a combination of conjugates for use in vaccines.
    Type: Application
    Filed: April 25, 2019
    Publication date: August 5, 2021
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Patrick Leonard AHL, Akhilesh BHAMBHANI, Christopher Jon FARRELL, Patrick McHUGH, Morrisa C. JONES, Daniel D. ROTH, Jessica R. SINACOLA, Justin STANBRO, Matthew P. WATSON, Emily WEN, Michael A. WINTERS
  • Publication number: 20210177957
    Abstract: The invention is related to multivalent immunogenic compositions comprising more than one S. pneumoniae polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an S. pneumoniae serotype conjugated to a carrier protein, wherein the serotypes of S. pneumoniae are as defined herein. In some embodiments, at least one of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. In further embodiments, each of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection against S. pneumoniae infection and diseases caused by S. pneumoniae.
    Type: Application
    Filed: December 4, 2018
    Publication date: June 17, 2021
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: William J. Smith, Patrick McHugh, Michael Albert Winters, Julie M. Skinner, Jian He, Luwy Musey, Chitrananda Abeygunawardana, Yadong Adam Cui, Michael J. Kosinski
  • Publication number: 20210038723
    Abstract: The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which capsular polysaccharides from one or more of these serotypes are conjugated to a carrier protein such as CRM197. Polysaccharide-protein conjugates from one or more of these serotypes may be included in multivalent pneumococcal conjugate vaccines having polysaccharides from multiple additional Steptococcus pneumoniae serotypes.
    Type: Application
    Filed: September 4, 2018
    Publication date: February 11, 2021
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Richard J. Porambo, Chitrananda Abeygunawardana, Luwy Kavuka Musey, Michael J. Kosinski, Yadong Adam Cui, Patrick McHugh, Janelle Konietzko
  • Publication number: 20200276316
    Abstract: The present invention provides a number of process improvements related to the conjugation of capsular polysaccharides from Streptococcus pneumoniae to a carrier protein. These process are serotype specific and include acid hydrolysis, addition of sodium chloride to the reductive amination reaction, and addition of sucrose to dissolve polysaccharides. Polysaccharide-protein conjugates prepared using the processes of the invention can be included in multivalent pneumococcal conjugate vaccines.
    Type: Application
    Filed: September 4, 2018
    Publication date: September 3, 2020
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Patrick McHugh, Michael Albert Winters, Janelle Konietzko
  • Publication number: 20200194978
    Abstract: A system for servicing cable includes a field-end assembly and a live-end assembly, each mounted on a support structure having at least one drive mechanism operable to cause relative linear movement between the field-end assembly and the live-end assembly. A drilling-and-shorting assembly can create a short circuit in a field-end of the cable, and a continuity tester can test the integrity of the short-circuit. The field end of the cable can then be ejected from the system, and an end-cap-cradle assembly can position an end cap on a live end of an electrical cable and test its installation.
    Type: Application
    Filed: December 16, 2019
    Publication date: June 18, 2020
    Inventors: Alex SYMINGTON, Dennis John SEMET, Caner OKTAYER, Aalap Rajendra SHAH, Than Lin HTAIK, Patrick McHUGH, Maggie CHOW, George MURRAY, Luis JEREZ, Thomas CAMPBELL, Michael BARATTA
  • Publication number: 20200061542
    Abstract: The present invention provides improved methods for preparing polysaccharide protein conjugates utilizing surfactants to improve filterability of the conjugation reaction mixture. The polysaccharide-protein conjugates are useful for inclusion in vaccines.
    Type: Application
    Filed: February 20, 2018
    Publication date: February 27, 2020
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Michael A. Winters, Patrick McHugh, Kyle Evans, Jian He, Josef Vlasak, Willam J. Smith
  • Publication number: 20200054733
    Abstract: The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from Streptococcus pneumoniae bacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.
    Type: Application
    Filed: February 20, 2018
    Publication date: February 20, 2020
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Jian He, John E. MacNair, William J. Smith, Michael A. Winters, Joseph G. Joyce, Chitrananda Abeygunawardana, Luwy Musey, Hari Pujar, Julie M. Skinner, Emily Wen, Patrick McHugh, John Michael Williams, Catherine Lancaster
  • Publication number: 20190337833
    Abstract: A submerged combustion melter includes a floor, a roof, and a sidewall structure connecting the floor and roof defining an internal space. A first portion of the internal space defines a melting zone, and a second portion defines a fining zone immediately downstream of the melting zone. One or more combustion burners in either the floor, roof, the sidewall structure, or any combination of these, are configured to emit the combustion gases from a position under a level of, and positioned to transfer heat to and produce, a turbulent molten mass of glass containing bubbles in the melting zone. The fining zone is devoid of combustion burners or other apparatus or components that would increase turbulence above that in the melting zone. The melter may include a treating zone that stabilizes or destabilizes bubbles and/or foam. Processes of using the melters are a feature of the disclosure.
    Type: Application
    Filed: July 17, 2019
    Publication date: November 7, 2019
    Inventors: Mark William Charbonneau, Kevin Patrick McHugh, Aaron Morgan Huber