Abstract: In one aspect, the present invention provides isolated nucleic acid molecules that encode a CAN-1 polypeptide, or an STG polypeptide. In another aspect, the present invention also provides isolated STG polypeptides, isolated CAN-1 polypeptides, and isolated SEEK-1 polypeptides. In another aspect, the present invention provides isolated antibodies that bind specifically to a CAN-1, SEEK-1 or STG polypeptide. In another aspect, the present invention provides methods of diagnosing or predicting the susceptibility to psoriasis of an individual. In another aspect, the present invention provides methods for ameliorating the symptoms and/or progression of psoriasis.

Abstract: This invention provides nucleic acids and polypeptides encoding a novel family of matrix metalloproteinases herein designated as MMP-25 and variants of the same. MMP-25 is preferentially expressed in skin cells of a mammal, particularly in breast cells and hair follicles. Expression in hair follicles is localized in the Henle layer of cells, indicating a role in hair growth. Also provided are fragments and oligonucleotides useful for identifying and isolating MMP-25-encoding nucleic acids and methods for their use, as well as antibodies that bind specifically to MMP-25 and vectors for expression of MMP-25 polypeptides. Methods of inhibiting MMP-25 activity are provided, including methods useful for inhibiting hair growth.