Abstract: Devices for isolating, collecting and/or transferring target molecules to an assay area, comprising an enclosure having a top section adapted to receive a sample, a central hollow body section or other area or cavity suitable for receiving a magnet or magnetic field(s) or force(s), at least one aqueous phase or layer and at least one oil/wax or gaseous phase or layer stabilized in proximity to one another within the enclosure with a target-permeable structural material associated with the aqueous phase/layer or the gaseous or oil/wax phase/layer or both, and a lower section containing or adapted to contain one or more reagents for carrying out an assay.

Abstract: A controlled temperature unit is disclosed herein. The various components of the controlled temperature unit allow the unit to control temperature and collect or manage temperature data in a novel and unique manner to fulfill an unmet need. The controlled temperature unit may be equipped with multiple temperature probes, and data generated by these probes may be managed by a process control unit housed within the wall of the controlled temperature unit. The process control unit may then be operable to display temperature related data on a visual display attached to one of the exterior walls of the controlled temperature unit. The scope of the present disclosure extends to all mechanical and electrically automated engineering features that may extend the lifespan of the validated state of a CTU.

Abstract: Provided herein are systems and methods for isolating a target from a biological sample. In some aspects, provided herein are automated systems and methods for isolating a target from a plurality of biological samples. For example, provided herein are automated systems and methods for isolating viral nucleic acid from a biological sample using a magnetic force to draw the nucleic acid out of a liquid biological sample.

Abstract: Provided herein are devices and methods for isolation and detection of an analyte from a sample. In some embodiments, provided herein are devices and methods of use thereof for vertical flow-based isolation and detection of analytes in a liquid sample, such as a urine sample.

Abstract: In some embodiments, a system for automatically evaluating slurry properties includes a down-hole measurement device configured to be lowered into slurry provided in an excavated hole, the measurement device comprising an outer housing, a flow pump, a flow meter, and a differential pressure sensor, wherein the flow pump is configured to pump slurry through the flow meter, the flow meter is configured to measure a flow rate of the pumped slurry, and the differential pressure sensor is configured to measure a difference in pressure between the pumped slurry and the slurry outside of the measurement device.

Abstract: A motor vehicle door latch, in particular a tailgate latch, which is equipped with a locking mechanism comprising a catch and a pawl. Furthermore, a triggering element working on the pawl is provided for which is set up at least to lift the pawl. Furthermore, a memory element, which at least guarantees an unimpeded opening movement of the catch when the pawl is lifted. The memory element maintains the pawl in its elevated position.

Abstract: In some embodiments, a system for automatically evaluating slurry properties includes a down-hole measurement device configured to be lowered into slurry provided in an excavated hole, the measurement device comprising an outer housing, a flow pump, a flow meter, and a differential pressure sensor, wherein the flow pump is configured to pump slurry through the flow meter, the flow meter is configured to measure a flow rate of the pumped slurry, and the differential pressure sensor is configured to measure a difference in pressure between the pumped slurry and the slurry outside of the measurement device.

Abstract: A motor vehicle door latch, in particular a tailgate latch, which is equipped with a locking mechanism comprising a catch and a pawl. Furthermore, a triggering element working on the pawl is provided for which is set up at least to lift the pawl. Furthermore, a memory element, which at least guarantees an unimpeded opening movement of the catch when the pawl is lifted. The memory element maintains the pawl in its elevated position.

Abstract: A photosensor control unit for use in a lighting module has a light sensor and a switch adapted to operably control a light source such as a plurality of LEDs responsive to the light sensor. The light source is adapted to be mounted in the lighting module, and is configured to produce light having wavelengths within a first range of wavelengths. The light sensor is adapted to be mounted on or about the lighting module, and is responsive to light having wavelengths within a second range of wavelengths. The second range of wavelengths is exclusive of the first range of wavelengths. The switch is adapted to operably control the light source responsive to the light sensor such that the light source emits light having wavelengths within the first range of wavelengths responsive to the presence or absence of light within the second range of wavelengths.

Abstract: A treatment process is disclosed that comprises administering an effective amount of an aromatic sulfone hydroxamic acid that exhibits excellent inhibitory activity of one or more matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-9, and MMP-13, while exhibiting substantially less inhibition at least of MMP-1 to a host having a condition associated with pathological matrix metalloprotease activity. The administered enzyme inhibitor corresponds in structure to formula (I), below, or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are both hydrido or R1 and R2 together with the atoms to which they are bonded form a 5- to 8-membered ring containing one, two, or three heteroatoms in the ring that are oxygen, sulfur, or nitrogen. R3 in formula (I) is an optionally substituted aryl or optionally substituted heteroaryl radical.

Abstract: This invention is directed generally to proteinase (also known as “protease”) inhibitors, and, more particularly, to piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and/or aggrecanase activity. Such hydroxamic acids generally correspond in structure to the following formula: (wherein A1, A2, Y, E1, E2, E3, and Rx are as defined in this specification), and further include salts of such compounds. This invention also is directed to compositions of such hydroxamic acids, intermediates for the syntheses of such hydroxamic acids, methods for making such hydroxamic acids, and methods for treating conditions (particularly pathological conditions) associated with MMP activity and/or aggrecanase activity.

Abstract: This invention is directed generally to proteinase (also known as “protease”) inhibitors, and, more particularly, to piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and/or aggrecanase activity. Such hydroxamic acids generally correspond in structure to the following formula: (wherein A1, A2, Y, E1, E2, E3, and Rx are as defined in this specification), and further include salts of such compounds. This invention also is directed to compositions of such hydroxamic acids, intermediates for the syntheses of such hydroxamic acids, methods for making such hydroxamic acids, and methods for treating conditions (particularly pathological conditions) associated with MMP activity and/or aggrecanase activity.

Abstract: A photosensor control unit for use in a lighting module has a plurality of LEDs, a light sensor, and a switch adapted to operably control the plurality of LEDs responsive to the light sensor. The plurality of LEDs are adapted to be mounted in the lighting module, and are configured to produce light having wavelengths within a first range of wavelengths. The light sensor is adapted to be mounted in the lighting module adjacent the plurality of LEDs, and is responsive to light having wavelengths within a second range of wavelengths. The second range of wavelengths is exclusive of the first range of wavelengths. The switch is adapted to operably control the plurality of LEDs responsive to the light sensor such that the plurality of LEDs emit light having wavelengths within the first range of wavelengths responsive to the presence or absence of light within the second range of wavelengths.

Abstract: A disclosed substrate includes an electrically insulating circuit board, a pair of electrical lead pads adapted for mounting a light-emitting diode (LED) on a first surface, and a heat dissipating structure on the first surface. The heat dissipating structure includes an LED thermal pad adapted to abut the LED when mounted on the electrical lead pads, and a heat dissipation region extending from, and thermally coupled to, the LED thermal pad. The substrate also includes a thermally conductive plating on a second surface of the substrate opposite the heat dissipation region. A described lighting assembly includes the substrate, multiple LEDs connected to the electrical lead pads of the substrate, and multiple traces of the substrate connect the LEDs in a series circuit electrically isolated from the heat dissipating structures.

Abstract: A method of epoxidizing an unsaturated compound having a carbon-to-carbon double bond to form an oxirane ring across the double bond comprising adding to said unsaturated compound (a) an organic acid capable of being oxidized to form a peracid; (b) an oxidizing agent selected from hydrogen peroxide or acetaldehyde monoperacetate, or a combination thereof; and (c) with or without an acid catalyst selected from a mineral acid or styrene sulfonic acid, or a combination thereof to form a reactant mixture; and forming the reactant mixture in a film against a wall of a thin-film reactor that is at a temperature sufficient to form a peracid from the organic acid, and contacting the film of reactant mixture against the film reactor wall for a time sufficient for reaction of a portion of the peracid with the unsaturated compound to form an oxirane ring across a double bond of the unsaturated compound. In another embodiment, preformed peracid and unsaturated compound are added directly to the thin-film reactor.

Abstract: A method of epoxidizing an unsaturated compound having a carbon-to-carbon double bond to form an oxirane ring across the double bond comprising adding to said unsaturated compound an oxidizing agent selected from hydrogen peroxide, acetaldehyde monoperacetate, an organic hydroperoxide, or a combination thereof, to form a reactant mixture; and forming the reactant mixture in a film against a wall of the thin-film reactor that is at a temperature sufficient for reaction of the oxidizing agent with the unsaturated compound to form an oxirane ring across a double bond of the unsaturated compound.

Abstract: Relay switching circuits for supplying power to a vehicle exterior lighting system to provide for daytime running lights and which are controlled by solid state logic circuits, depending upon the condition of either or both of the vehicle starter and ignition switches.

Abstract: In a Time Division Multiple Access (TDMA) communication network, a central office (CO) provides interactive communication between a service provider and a plurality of user terminals. To synchronize transmissions of the user terminals, a timebase timer in the CO generates modulo N-bit cyclical reference counts as time markers. In a downstream direction to the plurality of user terminals, time marker insertion units in the CO receive both (a) separate digital TDMA transport streams having a predetermined data rate including data packets and Media Access Control (MAC) packets that are interspersed between the data packets at predetermined intervals, and (b) the time markers generated by the timebase timer, and insert a currently received time marker count into a concurrently received MAC packet. The resultant downstream TDMA transport streams with the inserted time marker counts in the MAC packets are transmitted in continuous TDMA output transport stream to the remote user terminals.

Abstract: An automated daytime running light system for surface transport vehicles having headlights and taillights which includes a daytime running light control circuit which activates the highbeam filament of the headlights at a reduced power level whenever the vehicle ignition is ON and the starter motor OFF during daylight conditions. In one embodiment, the daytime running light control circuit activates the high beam filaments of the headlight at a reduced power level and also activates the parking lights to provide taillights whenever the vehicle ignition is ON and the starter motor OFF during daylight conditions.

Abstract: In a Time Division Multiple Access (TDMA) communication network, a central office (CO) provides interactive communication between a service provider and a plurality of user terminals. To synchronize transmissions of the user terminals, a timebase timer in the CO generates modulo N-bit cyclical reference counts as time markers. In a downstream direction to the plurality of user terminals, time marker insertion units in the CO receive both (a) separate digital TDMA transport streams having a predetermined data rate including data packets and Media Access Control (MAC) packets that are interspersed between the data packets at predetermined intervals, and (b) the time markers generated by the timebase timer, and insert a currently received time marker count into a concurrently received MAC packet. The resultant downstream TDMA transport streams with the inserted time marker counts in the MAC packets are transmitted in continuous TDMA output transport stream to the remote user terminals.