Abstract: A device, method and system for disease detection relating to the selective capture of an antigen in an analyte by a linked capture antibody, where the linked capture antibody is expressed on a nanobiosensing chip as a plurality of non-randomly oriented binding sites, within a functionalized surface, that are upwardly oriented. The device, method and system enable selective capture of an antigen in an analyte with a selectivity and sensitivity that is greater than that attainable without the plurality of non-randomly oriented binding sites that are upwardly oriented and active. The device, method and system enable selective detection of an antigen in an analyte.

Abstract: The present invention includes gene and protein expression profiles indicative of whether a cancer patient is likely to respond to treatment with irinotecan. By identifying such responsiveness, a treatment provider may determine in advance those patients who would benefit from such treatment, as well as identify alternative therapies for non-responders. The present invention further provide methods of using the gene and/or protein expression profiles and assays for identifying the presence of a gene and/or protein expression profile in a patient sample.

Abstract: The invention relates to novel kinase peptides and antibodies, as well as nucleic acids related to them. The peptides, antibodies and the nucleic acids are useful for the detection, staging and monitoring of the progression of a kinase-mediated disease, as well as for determining or monitoring the efficacy of treatment.

Abstract: The various embodiment described herein disclose an antibody protein analysis chip. The analysis chip comprises a substrate having a plurality of layers. At least one layer is a conductive layer comprising a conductive material. The analysis chip also comprises a main channel (straight-line and S-shaped configurations) etched in the conductive layer wherein the channel begins at a loading reservoir and ends at an outlet channel. A plurality of side channels are etched in the conductive layer. The side channels are in communication with the main channel and end in a well. A plurality of wells of the analysis chip comprise at least one protein-specific antibody. In addition, a kit is disclosed comprising an embodiment of the antibody protein analysis chip.