Abstract: A prostate biopsy guide system may comprise a horizontal slide member, a vertical support movably coupled to the horizontal slide member, a vertical slide member movably coupled to the vertical support, a needle mount coupled to the vertical slide member, and a locking mechanism coupled to the vertical slide member. The system may allow precise positioning and control of a biopsy needle for transperineal prostate biopsy procedures. The locking mechanism may enable selective locking of vertical movement and swivel movement in different configurations. The horizontal slide member may include rails and a crossbar for mounting to an ultrasound probe. The vertical support and slide member may allow controlled vertical and angular adjustment of the needle mount.

Abstract: In some aspects, the disclosure provides systems and methods for delivering a conformable, fillable balloon to a target location. A balloon delivery system and balloon may include a tubular elongate shaft with a first lumen extending from a proximal end to a distal end and a hypotube with a second lumen extending from a proximal end to a distal end. A conformable, fillable balloon may be releasably coupled to the distal end of the elongate shaft or hypotube. The balloon may be expandable from a compressed lower profile delivery configuration to an expanded deployed configuration. An interior cavity of the balloon may be in fluid communication with the lumen of the elongate shaft. The balloon is configured to contain a filler material and bound the spread of the filler material as it gels or hardens.

Abstract: A delivery device comprises a first syringe, a second syringe, a needle or a tube, and a Y-connector that includes at least one access port.

Abstract: In some aspects, the present disclosure pertains to a hydrogel agitation and injection assembly, the assembly comprising a delivery device providing a barrel configured as a reservoir for an injectable hydrogel; and a shuttle disposed in the reservoir, where the shuttle is configured at least to translate along a longitudinal axis of the delivery device responsive to an application of a magnetic field to the shuttle, and where the shuttle includes an aperture extending entirely through the shuttle along the longitudinal axis of the delivery device.

Abstract: A medical device may comprise a handle, which may include a grip portion; a body portion; and a ram housing extending proximally of the body portion; and a shaft having a first, proximal portion and a second, distal portion. The first portion of the shaft may include a first outer sheath. The second portion of the shaft may include a second outer sheath. The first outer sheath may be more rigid than the second outer sheath. The medical device may further comprise a rigid ram extending through at least a portion of the body portion and at least a portion of the shaft. The ram may be configured to be transitioned from a first, proximal configuration, in which the second portion of the shaft is flexible, and a second, distal configuration, in which the second portion of the shaft is rigid.

Abstract: A thermal ablation device includes an elongated member sized and shaped for insertion into a uterus via a cervical opening. The elongated member defines a first lumen extending therethrough to a first distal opening which, when the apparatus is in an operative position, opens into the uterus and a seal positioned on the elongated member so that, when the elongated member is in the operative position, the seal engages cervical tissue around a circumference of the elongated member and prevent fluids introduced into the uterus via the first lumen from flowing therepast into the cervix. The seal includes a plurality of flexible members separated from one another along a length of the elongated member and projecting radially outward from an outer surface of the elongated member.

Abstract: A thermal ablation device includes an elongated member sized and shaped for insertion into a uterus via a cervical opening. The elongated member defines a first lumen extending therethrough to a first distal opening which, when the apparatus is in an operative position, opens into the uterus and a seal positioned on the elongated member so that, when the elongated member is in the operative position, the seal engages cervical tissue around a circumference of the elongated member and prevent fluids introduced into the uterus via the first lumen from flowing therepast into the cervix. The seal includes a plurality of flexible members separated from one another along a length of the elongated member and projecting radially outward from an outer surface of the elongated member.

Abstract: The present invention relates to a method of treatment of bacterial infections including administering an effective amount of an oral time-dependent antibiotic to a human or warm blooded animal.