Abstract: The present technology includes an implant for treating excessive central airway collapse (ECAC) of an airway. The implant can comprise a wire-form stent configured to be positioned within the airway. The stent can comprise a C-shaped sidewall, and is configured to be positioned within the airway such that the C-shaped sidewall is positioned proximate a cartilaginous portion of the airway and presses outwardly against the cartilaginous portion.

Abstract: An implant in accordance with an embodiment of the present technology includes proximal and distal end portions spaced apart from one another along a longitudinal axis and configured to be deployed at first and second airways, respectively, of a bronchial tree, the second airway being of a greater generation than the first airway. The implant includes a wire extending along a wire path within a tubular region coaxially aligned with the longitudinal axis. The wire includes first and second legs alternatingly disposed along the wire path and extending distally and proximally, respectively, in a circumferential direction about the longitudinal axis. The implant is configured to transition from a low-profile delivery state to an expanded deployed state at a treatment location and to allow mucociliary clearance from immediately distal to the implant to immediately proximal to the implant while the in deployed at the treatment location.

Abstract: The present technology is directed to devices, systems, and methods for improving pulmonary function in a human subject. The present technology includes a robotic system configured to assist in delivery and deployment of an implant in an airway of a patient. The robotic system can comprise a workstation for engaging with and receiving instructions from a treatment provider and an arm in operative communication with the workstation. The arm can comprise an instrument driver and an articulatable instrument. The articulatable instrument can comprises an elongate member having a proximal portion coupled to the instrument driver, a distal portion configured for positioning in a bronchial airway of the human subject, and a working channel extending from the proximal portion to the distal portion. The working channel can be configured to receive a delivery system containing the airway implant therethrough.

Abstract: Endobrochial implants and delivery systems therefor are disclosed herein. In some embodiments, a delivery system can be used for deploying an implant at a treatment location, where the implant includes a tubular region with one or more interstitial regions. A delivery system can, for example include a flexible elongate member having an implant mounting surface, wherein the implant mounting surface comprises a conformable material configured to adapt to the one or more interstitial regions of the implant when the implant is radially collapsed on the implant mounting surface, thereby engaging the implant. The delivery system can also include a sheath at least partially covering the elongate member, wherein the sheath is movable relative to the elongate member to at least partially expose the implant mounting surface.

Abstract: An implant in accordance with an embodiment of the present technology includes proximal and distal end portions spaced apart from one another along a longitudinal axis and configured to be deployed at first and second airways, respectively, of a bronchial tree, the second airway being of a greater generation than the first airway. The implant includes a wire extending along a wire path within a tubular region coaxially aligned with the longitudinal axis. The wire includes first and second legs alternatingly disposed along the wire path and extending distally and proximally, respectively, in a circumferential direction about the longitudinal axis. The implant is configured to transition from a low-profile delivery state to an expanded deployed state at a treatment location and to allow mucociliary clearance from immediately distal to the implant to immediately proximal to the implant while the in deployed at the treatment location.

Abstract: Methods for planning, predictive modeling, and monitoring therapies for pulmonary diseases are provided. In some embodiments, a method for planning a treatment for a patient having a pulmonary disease includes receiving patient data including computed tomography (CT) data of a lung of the patient. The method can include generating a set of lung metrics by inputting the patient data into a first machine learning algorithm. The method can also include predicting a response of the patient to treatment for the pulmonary disease by inputting the set of lung metrics into a second machine learning algorithm. The method can further include evaluating whether the patient is a candidate for the treatment for the pulmonary disease, based on the predicted response. The method can further include evaluating whether the patient has benefited following treatment and whether additional treatment is warranted.

Abstract: An implant in accordance with an embodiment of the present technology includes proximal and distal end portions spaced apart from one another along a longitudinal axis and configured to be deployed at first and second airways, respectively, of a bronchial tree, the second airway being of a greater generation than the first airway. The implant includes a wire extending along a wire path within a tubular region coaxially aligned with the longitudinal axis. The wire includes first and second legs alternatingly disposed along the wire path and extending distally and proximally, respectively, in a circumferential direction about the longitudinal axis. The implant is configured to transition from a low-profile delivery state to an expanded deployed state at a treatment location and to allow mucociliary clearance from immediately distal to the implant to immediately proximal to the implant while the in deployed at the treatment location.

Abstract: An implant in accordance with an embodiment of the present technology includes proximal and distal end portions spaced apart from one another along a longitudinal axis and configured to be deployed at first and second airways, respectively, of a bronchial tree, the second airway being of a greater generation than the first airway. The implant includes a wire extending along a wire path within a tubular region coaxially aligned with the longitudinal axis. The wire includes first and second legs alternatingly disposed along the wire path and extending distally and proximally, respectively, in a circumferential direction about the longitudinal axis. The implant is configured to transition from a low-profile delivery state to an expanded deployed state at a treatment location and to allow mucociliary clearance from immediately distal to the implant to immediately proximal to the implant while the in deployed at the treatment location.

Abstract: Delivery systems, methods and associated devices to facilitate delivery and deployment of a heart implant. Such delivery systems and methods of delivery include use of a pair of magnetic catheters, including an anchor delivery catheter carrying an anchor, which can be stacked with or can be axially offset from the magnetic head. Such systems further include use of a puncturing guidewire advanceable through the magnetic head of the anchor delivery catheter to establish access to a chamber of a heart and which is attached to a bridging element such that continued advancement of the guidewire draws a bridging element attached to the first anchor across the chamber of the heart while the bridging element remains covered by the magnetically coupled catheters. Methods and devices herein also allow for cutting and removal of a bridge element of a deployed heart implant.

Abstract: An implant in accordance with an embodiment of the present technology includes proximal and distal end portions spaced apart from one another along a longitudinal axis and configured to be deployed at first and second airways, respectively, of a bronchial tree, the second airway being of a greater generation than the first airway. The implant includes a wire extending along a wire path within a tubular region coaxially aligned with the longitudinal axis. The wire includes first and second legs alternatingly disposed along the wire path and extending distally and proximally, respectively, in a circumferential direction about the longitudinal axis. The implant is configured to transition from a low-profile delivery state to an expanded deployed state at a treatment location and to allow mucociliary clearance from immediately distal to the implant to immediately proximal to the implant while the in deployed at the treatment location.

Abstract: A method for traversing an anatomical vessel wall of a subject is provided. The invention allows the crossing of a wire from one anatomical lumen, such as an artery, vein, esophagus, intestine or airway, through tissue, into another anatomical lumen, or cavity, or into a solid mass of tissue. In some aspects, the invention allows the crossing of a wire from the greater cardiac vein (GCV) into the left atrium without relying on another device in the left atrium to facilitate the crossing.

Abstract: Anchors for securing an implant within a body organ and/or reshaping a body organ are provided herein. Anchors are configured for deployment in a body lumen or vasculature of the patient that are curved or conformable to accommodate anatomy of the patient. The invention provides an implant system having multiple anchors, e.g., one or more posterior anchors in combination with one or more anterior anchors. Methods of deploying such anchors, and use of multiple anchors or multiple bridging elements are also provided.

Abstract: Delivery systems, methods and associated devices to facilitate delivery and deployment of a heart implant. Such delivery systems and methods of delivery include use of a pair of magnetic catheters, including an anchor delivery catheter carrying an anchor, which can be stacked with or can be axially offset from the magnetic head. Such systems further include use of a puncturing guidewire advanceable through the magnetic head of the anchor delivery catheter to establish access to a chamber of a heart and which is attached to a bridging element such that continued advancement of the guidewire draws a bridging element attached to the first anchor across the chamber of the heart while the bridging element remains covered by the magnetically coupled catheters. Methods and devices herein also allow for cutting and removal of a bridge element of a deployed heart implant.

Abstract: An ablation assembly includes a handle, a catheter assembly and a connector locking assembly. The catheter assembly includes: a catheter shaft, a balloon and a connector at the distal and proximal ends of the catheter shaft, and a delivery tube extending between there between. The connector includes a connector body secured to the proximal end and a plug secured to the delivery tube, the plug and delivery tube movable axially and rotationally. The handle includes an open portion receiving the plug and the connector body. The connector locking assembly includes: means for simultaneously automatically connecting the plug and the connector body to the handle to place the connector in a load state prior to use, and means for automatically releasing the connector body and thereafter the plug from the handle to place the connector in an eject state to permit the connector to be removed from the handle.

Abstract: An ablation assembly includes a handle, a catheter assembly and a connector locking assembly. The catheter assembly includes: a catheter shaft, a balloon and a connector at the distal and proximal ends of the catheter shaft, and a delivery tube extending between there between. The connector includes a connector body secured to the proximal end and a plug secured to the delivery tube, the plug and delivery tube movable axially and rotationally. The handle includes an open portion receiving the plug and the connector body. The connector locking assembly includes: means for simultaneously automatically connecting the plug and the connector body to the handle to place the connector in a load state prior to use, and means for automatically releasing the connector body and thereafter the plug from the handle to place the connector in an eject state to permit the connector to be removed from the handle.

Abstract: An ablation assembly includes a handle, a catheter assembly and a connector locking assembly. The catheter assembly includes: a catheter shaft, a balloon and a connector at the distal and proximal ends of the catheter shaft, and a delivery tube extending between there between. The connector includes a connector body secured to the proximal end and a plug secured to the delivery tube, the plug and delivery tube movable axially and rotationally. The handle includes an open portion receiving the plug and the connector body. The connector locking assembly includes: means for simultaneously automatically connecting the plug and the connector body to the handle to place the connector in a load state prior to use, and means for automatically releasing the connector body and thereafter the plug from the handle to place the connector in an eject state to permit the connector to be removed from the handle.

Abstract: A cryogenic ablation catheter includes a catheter shaft, a balloon and a connector respectively at the catheter shaft proximal and distal ends, a refrigerant delivery tube assembly including a refrigerant delivery tube translatable within the catheter shaft lumen, and a refrigerant delivery element with an outlet located inside the balloon which directs refrigerant outwardly against the balloon at different axial positions as it translates. A cryogenic balloon ablation system includes the cryogenic ablation catheter, a catheter coupler mating with the connector, a linear motion assembly, and a connection line fluidly coupled to a refrigerant fluid source for supplying refrigerant fluid to the refrigerant delivery tube.

Abstract: An ablation assembly includes a handle, a catheter assembly and a connector locking assembly. The catheter assembly includes: a catheter shaft, a balloon and a connector at the distal and proximal ends of the catheter shaft, and a delivery tube extending between there between. The connector includes a connector body secured to the proximal end and a plug secured to the delivery tube, the plug and delivery tube movable axially and rotationally. The handle includes an open portion receiving the plug and the connector body. The connector locking assembly includes: means for simultaneously automatically connecting the plug and the connector body to the handle to place the connector in a load state prior to use, and means for automatically releasing the connector body and thereafter the plug from the handle to place the connector in an eject state to permit the connector to be removed from the handle.

Abstract: Various embodiments of stents with radiopaque markers arranged in patterns are described herein.

Abstract: A cryogenic ablation catheter includes a catheter shaft, a balloon and a connector respectively at the catheter shaft proximal and distal ends, a refrigerant delivery tube assembly including a refrigerant delivery tube translatable within the catheter shaft lumen, and a refrigerant delivery element with an outlet located inside the balloon which directs refrigerant outwardly against the balloon at different axial positions as it translates. A cryogenic balloon ablation system includes the cryogenic ablation catheter, a catheter coupler mating with the connector, a linear motion assembly, and a connection line fluidly coupled to a refrigerant fluid source for supplying refrigerant fluid to the refrigerant delivery tube.