Abstract: An implant in accordance with an embodiment of the present technology includes proximal and distal end portions spaced apart from one another along a longitudinal axis and configured to be deployed at first and second airways, respectively, of a bronchial tree, the second airway being of a greater generation than the first airway. The implant includes a wire extending along a wire path within a tubular region coaxially aligned with the longitudinal axis. The wire includes first and second legs alternatingly disposed along the wire path and extending distally and proximally, respectively, in a circumferential direction about the longitudinal axis. The implant is configured to transition from a low-profile delivery state to an expanded deployed state at a treatment location and to allow mucociliary clearance from immediately distal to the implant to immediately proximal to the implant while the in deployed at the treatment location.

Abstract: Delivery systems, methods and associated devices to facilitate delivery and deployment of a heart implant. Such delivery systems and methods of delivery include use of a pair of magnetic catheters, including an anchor delivery catheter carrying an anchor, which can be stacked with or can be axially offset from the magnetic head. Such systems further include use of a puncturing guidewire advanceable through the magnetic head of the anchor delivery catheter to establish access to a chamber of a heart and which is attached to a bridging element such that continued advancement of the guidewire draws a bridging element attached to the first anchor across the chamber of the heart while the bridging element remains covered by the magnetically coupled catheters. Methods and devices herein also allow for cutting and removal of a bridge element of a deployed heart implant.

Abstract: An implant in accordance with an embodiment of the present technology includes proximal and distal end portions spaced apart from one another along a longitudinal axis and configured to be deployed at first and second airways, respectively, of a bronchial tree, the second airway being of a greater generation than the first airway. The implant includes a wire extending along a wire path within a tubular region coaxially aligned with the longitudinal axis. The wire includes first and second legs alternatingly disposed along the wire path and extending distally and proximally, respectively, in a circumferential direction about the longitudinal axis. The implant is configured to transition from a low-profile delivery state to an expanded deployed state at a treatment location and to allow mucociliary clearance from immediately distal to the implant to immediately proximal to the implant while the in deployed at the treatment location.

Abstract: A method for traversing an anatomical vessel wall of a subject is provided. The invention allows the crossing of a wire from one anatomical lumen, such as an artery, vein, esophagus, intestine or airway, through tissue, into another anatomical lumen, or cavity, or into a solid mass of tissue. In some aspects, the invention allows the crossing of a wire from the greater cardiac vein (GCV) into the left atrium without relying on another device in the left atrium to facilitate the crossing.

Abstract: Anchors for securing an implant within a body organ and/or reshaping a body organ are provided herein. Anchors are configured for deployment in a body lumen or vasculature of the patient that are curved or conformable to accommodate anatomy of the patient. The invention provides an implant system having multiple anchors, e.g., one or more posterior anchors in combination with one or more anterior anchors. Methods of deploying such anchors, and use of multiple anchors or multiple bridging elements are also provided.

Abstract: Delivery systems, methods and associated devices to facilitate delivery and deployment of a heart implant. Such delivery systems and methods of delivery include use of a pair of magnetic catheters, including an anchor delivery catheter carrying an anchor, which can be stacked with or can be axially offset from the magnetic head. Such systems further include use of a puncturing guidewire advanceable through the magnetic head of the anchor delivery catheter to establish access to a chamber of a heart and which is attached to a bridging element such that continued advancement of the guidewire draws a bridging element attached to the first anchor across the chamber of the heart while the bridging element remains covered by the magnetically coupled catheters. Methods and devices herein also allow for cutting and removal of a bridge element of a deployed heart implant.

Abstract: An ablation assembly includes a handle, a catheter assembly and a connector locking assembly. The catheter assembly includes: a catheter shaft, a balloon and a connector at the distal and proximal ends of the catheter shaft, and a delivery tube extending between there between. The connector includes a connector body secured to the proximal end and a plug secured to the delivery tube, the plug and delivery tube movable axially and rotationally. The handle includes an open portion receiving the plug and the connector body. The connector locking assembly includes: means for simultaneously automatically connecting the plug and the connector body to the handle to place the connector in a load state prior to use, and means for automatically releasing the connector body and thereafter the plug from the handle to place the connector in an eject state to permit the connector to be removed from the handle.

Abstract: An ablation assembly includes a handle, a catheter assembly and a connector locking assembly. The catheter assembly includes: a catheter shaft, a balloon and a connector at the distal and proximal ends of the catheter shaft, and a delivery tube extending between there between. The connector includes a connector body secured to the proximal end and a plug secured to the delivery tube, the plug and delivery tube movable axially and rotationally. The handle includes an open portion receiving the plug and the connector body. The connector locking assembly includes: means for simultaneously automatically connecting the plug and the connector body to the handle to place the connector in a load state prior to use, and means for automatically releasing the connector body and thereafter the plug from the handle to place the connector in an eject state to permit the connector to be removed from the handle.

Abstract: An ablation assembly includes a handle, a catheter assembly and a connector locking assembly. The catheter assembly includes: a catheter shaft, a balloon and a connector at the distal and proximal ends of the catheter shaft, and a delivery tube extending between there between. The connector includes a connector body secured to the proximal end and a plug secured to the delivery tube, the plug and delivery tube movable axially and rotationally. The handle includes an open portion receiving the plug and the connector body. The connector locking assembly includes: means for simultaneously automatically connecting the plug and the connector body to the handle to place the connector in a load state prior to use, and means for automatically releasing the connector body and thereafter the plug from the handle to place the connector in an eject state to permit the connector to be removed from the handle.

Abstract: A cryogenic ablation catheter includes a catheter shaft, a balloon and a connector respectively at the catheter shaft proximal and distal ends, a refrigerant delivery tube assembly including a refrigerant delivery tube translatable within the catheter shaft lumen, and a refrigerant delivery element with an outlet located inside the balloon which directs refrigerant outwardly against the balloon at different axial positions as it translates. A cryogenic balloon ablation system includes the cryogenic ablation catheter, a catheter coupler mating with the connector, a linear motion assembly, and a connection line fluidly coupled to a refrigerant fluid source for supplying refrigerant fluid to the refrigerant delivery tube.

Abstract: An ablation assembly includes a handle, a catheter assembly and a connector locking assembly. The catheter assembly includes: a catheter shaft, a balloon and a connector at the distal and proximal ends of the catheter shaft, and a delivery tube extending between there between. The connector includes a connector body secured to the proximal end and a plug secured to the delivery tube, the plug and delivery tube movable axially and rotationally. The handle includes an open portion receiving the plug and the connector body. The connector locking assembly includes: means for simultaneously automatically connecting the plug and the connector body to the handle to place the connector in a load state prior to use, and means for automatically releasing the connector body and thereafter the plug from the handle to place the connector in an eject state to permit the connector to be removed from the handle.

Abstract: Various embodiments of stents with radiopaque markers arranged in patterns are described herein.

Abstract: A cryogenic ablation catheter includes a catheter shaft, a balloon and a connector respectively at the catheter shaft proximal and distal ends, a refrigerant delivery tube assembly including a refrigerant delivery tube translatable within the catheter shaft lumen, and a refrigerant delivery element with an outlet located inside the balloon which directs refrigerant outwardly against the balloon at different axial positions as it translates. A cryogenic balloon ablation system includes the cryogenic ablation catheter, a catheter coupler mating with the connector, a linear motion assembly, and a connection line fluidly coupled to a refrigerant fluid source for supplying refrigerant fluid to the refrigerant delivery tube.

Abstract: A mandrel for supporting a stent and rollers for pressing a radiopaque marker into a stent are disclosed. The mandrel can have a forward portion for carrying the stent and a rear portion for urging the stent forward portion into a gap between the rollers. The mandrel may be pushed or pulled into the gap, which is sized to allow the rollers to press the marker into engagement with the stent. Prior to moving the mandrel into the gap, the marker may be placed on a surface of the stent or partially inside a recess in the stent. Several markers can be efficiently and uniformly pressed onto the stent by moving the mandrel into the gap in one continuous movement in an axial or lateral direction. Markers can also be pressed onto the stent by placing the stent in the gap and rotating the stent about its central axis.

Abstract: Various embodiments of stents with radiopaque markers arranged in patterns are described herein.

Abstract: A cryogenic ablation catheter includes a catheter shaft, a balloon and a connector respectively at the catheter shaft proximal and distal ends, a refrigerant delivery tube assembly including a refrigerant delivery tube translatable within the catheter shaft lumen, and a refrigerant delivery element with an outlet located inside the balloon which directs refrigerant outwardly against the balloon at different axial positions as it translates. A cryogenic balloon ablation system includes the cryogenic ablation catheter, a catheter coupler mating with the connector, a linear motion assembly, and a connection line fluidly coupled to a refrigerant fluid source for supplying refrigerant fluid to the refrigerant delivery tube.

Abstract: Various embodiments of stents with radiopaque markers arranged in patterns are described herein.

Abstract: A focal ablation assembly, used with an endoscope comprising an endoscopic tube, comprises a cryogenic catheter, a balloon and a reinforcing element. The cryogenic catheter is placeable within the endoscopic tube channel and has a distal end placeable at the distal end of the endoscopic tube. The balloon is mountable to the catheter distal end and extends distally of both of the distal ends. The reinforcing element at least partially defines the shape of the balloon in the expanded state. The balloon defines a balloon volume when expanded and has a thermally conductive therapeutic region which provides effectively no thermal insulation. In some examples the focal ablation assembly comprises a delivery catheter extending along the channel with a distal portion fluidly coupled to the balloon interior, whereby refrigerant can be introduced into the balloon interior and towards the therapeutic region by the delivery catheter.

Abstract: Various embodiments of stents with radiopaque markers arranged in patterns are described herein.