Abstract: Provided herein are methods to prepare Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein. The Heteroaryl compounds are useful for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions.

Abstract: Provided herein are Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

Abstract: Provided herein are Heteroaryl Compounds of formula (I): wherein R1 and R2 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing inflammatory conditions or cancer, and conditions treatable or preventable by inhibition of a kinase or a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a subject in need thereof.

Abstract: Provided herein are compounds having TNF? and/or PDE4 and/or B-RAF inhibitory activity, and compositions thereof. In particular, provided herein are compounds of the formula I: and pharmaceutically acceptable salts, solvates, hydrates, clathrates, stereoisomers, polymorphs and prodrugs thereof, wherein Ar, R1, R2, R3, R4, n and Z are as described herein. Further provided herein are methods for treating or preventing various diseases and disorders by administering to a patient one or more TNF? and/or PDE4 and/or B-RAF inhibitors. In particular, provided herein are methods for preventing or treating cancer, inflammatory disorders, cognition and memory disorders and autoimmune disorders, or one or more symptoms thereof by administering to a patient one or more TNF? and/or PDE4 and/or B-RAF inhibitors.

Abstract: A method for making a search coil frame assembly for a metal detector, the method comprising providing a plurality of frame members, each having an aperture therethrough, providing selected ones of the frame members, respectively, with first, second and third grooves in face surfaces thereof, the grooves being formed so as to extend substantially around the apertures and to an edge of the frame member, placing electrically conductive strands in the grooves, and bonding the frame members together to close the grooves with the strands therein, the grooves being disposed such that the first and third grooves are spaced from the second groove by substantially equal distances on opposite sides of the second groove, the apertures forming a passage through the bonded frame members, and the strands substantially encircling the passage and extending from the frame.

Abstract: A method for making a search coil frame assembly for a metal detector, the method comprising providing a plurality of frame members, each having an aperture therethrough, providing selected ones of the frame members, respectively, with first, second and third grooves in face surfaces thereof, the grooves being formed so as to extend substantially around the apertures and to an edge of the frame member, placing electrically conductive strands in the grooves, and bonding the frame members together to close the grooves with the strands therein, the grooves being disposed such that the first and third grooves are spaced from the second groove by substantially equal distances on opposite sides of the second groove, the apertures forming a passage through the bonded frame members, and the strands substantially encircling the passage and extending from the frame; and the search coil frame assembly made in accordance with the aforesaid method.