Patents by Inventor Patrick Paullier
Patrick Paullier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11903382Abstract: Disclosed is a device for the perfusion of an organ, including: a container of fluid, containing an organ bathed in the perfusion fluid; a first path including an inlet, an outlet and a pump; and a second path including an inlet, an outlet and a pump. The “arterial” outlet of the first path has a diameter smaller than a diameter of the “portal” outlet of the second path. The device additionally includes, between the pump and the outlet of the first path and/or between the pump and the outlet of the second path, an oxygenation unit arranged to oxygenate the fluid emerging from the “arterial” outlet of the first path more than the fluid emerging from the “portal” outlet of the second path. The device can include a communication path between the first path and the second path in order to oxygenate the second path. Use in liver transplantation.Type: GrantFiled: January 11, 2023Date of Patent: February 20, 2024Assignees: UNIVERSITE DE TECHNOLOGIE DE COMPIEGNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, ASSISTANCE PUBLIQUE-HOPITAUX DE PARISInventors: Cécile Legallais, Patrick Paullier, Olivier Scatton, Eric Savier
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Publication number: 20230145640Abstract: Disclosed is a device for the perfusion of an organ, including: a container of fluid, containing an organ bathed in the perfusion fluid; a first path including an inlet, an outlet and a pump; and a second path including an inlet, an outlet and a pump. The “arterial” outlet of the first path has a diameter smaller than a diameter of the “portal” outlet of the second path. The device additionally includes, between the pump and the outlet of the first path and/or between the pump and the outlet of the second path, an oxygenation unit arranged to oxygenate the fluid emerging from the “arterial” outlet of the first path more than the fluid emerging from the “portal” outlet of the second path. The device can include a communication path between the first path and the second path in order to oxygenate the second path. Use in liver transplantation.Type: ApplicationFiled: January 11, 2023Publication date: May 11, 2023Inventors: Cécile LEGALLAIS, Patrick PAULLIER, Olivier SCATTON, Eric SAVIER
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Patent number: 11576371Abstract: Disclosed is a device for the perfusion of an organ, including: a container of fluid, containing an organ bathed in the perfusion fluid; a first path including an inlet, an outlet and a pump; and a second path including an inlet, an outlet and a pump. The “arterial” outlet of the first path has a diameter smaller than a diameter of the “portal” outlet of the second path. The device additionally includes, between the pump and the outlet of the first path and/or between the pump and the outlet of the second path, an oxygenation unit arranged to oxygenate the fluid emerging from the “arterial” outlet of the first path more than the fluid emerging from the “portal” outlet of the second path. The device can include a communication path between the first path and the second path in order to oxygenate the second path. Use in liver transplantation.Type: GrantFiled: June 12, 2018Date of Patent: February 14, 2023Assignees: UNIVERSITE DE TECHNOLOGIE DE COMPIEGNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, ASSISTANCE PUBLIQUE - HOPITAUX DE PARISInventors: Cécile Legallais, Patrick Paullier, Olivier Scatton, Eric Savier
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Publication number: 20210112805Abstract: Disclosed is a device for the perfusion of an organ, including: a container of fluid, containing an organ bathed in the perfusion fluid; a first path including an inlet, an outlet and a pump; and a second path including an inlet, an outlet and a pump. The “arterial” outlet of the first path has a diameter smaller than a diameter of the “portal” outlet of the second path. The device additionally includes, between the pump and the outlet of the first path and/or between the pump and the outlet of the second path, an oxygenation unit arranged to oxygenate the fluid emerging from the “arterial” outlet of the first path more than the fluid emerging from the “portal” outlet of the second path. The device can include a communication path between the first path and the second path in order to oxygenate the second path. Use in liver transplantation.Type: ApplicationFiled: June 12, 2018Publication date: April 22, 2021Inventors: Cécile LEGALLAIS, Patrick PAULLIER, Olivier SCATTON, Eric SAVIER
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Patent number: 10119112Abstract: The present invention relates to a unit (1) comprising a microsystem (150) and at least one set of interface connections (16) for the microsystem (150); the microsystem (150) comprising a bottom plate (152) bearing the impression of at least one microstructured dynamic cell culture chamber (15), and a top plate (151), characterized in that the at least one microstructured chamber (15) is fluidically connected at inlet and/or at outlet by a set of connections (16) inserted removably into a hole in the upper plate (151). The present invention also relates to a dynamic cell culture system to this effect.Type: GrantFiled: March 2, 2011Date of Patent: November 6, 2018Assignees: Universite Technologie De Compiegne—UTC, Centre National de la Recherche Scientifique (CNRS)Inventors: Cécile Legallais, Régis Baudoin, Eric Leclerc, Jean-Matthieu Prot, Patrick Paullier
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Patent number: 9963669Abstract: The invention concerns a facility for coupling a bioreactor for culturing bio-organisms, in dynamic mode, with at least one device for physicochemically analyzing a fluid from this bioreactor or collecting samples of this fluid, the device being equipped with a pump and an injector, the bioreactor being equipped with means for supplying culture medium and xenobiotic(s). The facility is remarkable in that the bioreactor is connected to a closed perfusion loop provided with a pump, fitted with a sampling loop and in that the facility comprises: a device for injecting a cleaning product into said sampling loop, two six-way valves, the first valve being connected to the closed perfusion loop, to the sampling loop and to a cleaning loop, the second valve being connected to the cleaning loop and an injection loop that connects the injector to at least one of the devices.Type: GrantFiled: December 1, 2014Date of Patent: May 8, 2018Assignees: Universite Technologie De Compiegne—UTC, Centre National de la Recherche Scientifique (CNRS)Inventors: Eric Leclerc, Patrick Paullier, Franck Merlier
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Publication number: 20170096629Abstract: The invention relates to a filtration device (100), characterized in that it includes: a first block (101) having a cavity forming a first chamber (110) comprising a bottom wall (111) having a set of microstructures including micro-walls and micro-contacts, the set of microstructures defining micro-chambers and micro-channels on the bottom wall (111) of the culture chamber; a second block (102) having a cavity forming a second chamber (120); and a filtration membrane (130), the first block (101), the membrane (130), and the second block (102) being arranged such that the membrane (130) is located between the first chamber (110) and the second chamber (120), adjacent to each of the first and second chambers (110, 120); as well as a first opening and a second opening for enabling a first fluid to pass into the second chamber (120) which is separated from the first chamber (110) by the membrane (130).Type: ApplicationFiled: December 16, 2016Publication date: April 6, 2017Inventors: Patrick Paullier, Aissa Ould Dris, Eric Leclerc
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Publication number: 20160304826Abstract: The invention concerns a facility for coupling a bioreactor for culturing bio-organisms, in dynamic mode, with at least one device for physicochemically analyzing a fluid from this bioreactor or collecting samples of this fluid, the device being equipped with a pump and an injector, the bioreactor being equipped with means for supplying culture medium and xenobiotic(s). The facility is remarkable in that the bioreactor is connected to a closed perfusion loop provided with a pump, fitted with a sampling loop and in that the facility comprises: a device for injecting a cleaning product into said sampling loop, two six-way valves, the first valve being connected to the closed perfusion loop, to the sampling loop and to a cleaning loop, the second valve being connected to the cleaning loop and an injection loop that connects the injector to at least one of the devices.Type: ApplicationFiled: December 1, 2014Publication date: October 20, 2016Applicants: Universite Technologie De Compiegne - UTC, Centre National de la Recherche Scientifique (CNRS )Inventors: Eric Leclerc, Patrick Paullier, Franck Merlier
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Publication number: 20130084632Abstract: The present invention relates to a unit (1) comprising a microsystem (150) and at least one set of interface connections (16) for the microsystem (150); the microsystem (150) comprising a bottom plate (152) bearing the impression of at least one microstructured dynamic cell culture chamber (15), and a top plate (151), characterized in that the at least one microstructured chamber (15) is fluidically connected at inlet and/or at outlet by a set of connections (16) inserted removably into a hole in the upper plate (151). The present invention also relates to a dynamic cell culture system to this effect.Type: ApplicationFiled: March 2, 2011Publication date: April 4, 2013Applicants: CENTRE BENJAMIN FRANKLIN, UNIVERSITE TECHNOLOGIE DE COMPIEGNE - UTCInventors: Cécile Legallais, Régis Baudoin, Eric Leclerc, Jean-Matthieu Prot, Patrick Paullier
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Publication number: 20130005027Abstract: The invention relates to a filtration device (100), characterized in that it includes: a first block (101) having a cavity forming a first chamber (110) comprising a bottom wall (111) having a set of microstructures including micro-walls and micro-contacts, the set of microstructures defining micro-chambers and micro-channels on the bottom wall (111) of the culture chamber; a second block (102) having a cavity forming a second chamber (120); and a filtration membrane (130), the first block (101), the membrane (130), and the second block (102) being arranged such that the membrane (130) is located between the first chamber (110) and the second chamber (120), adjacent to each of the first and second chambers (110, 120); as well as a first opening and a second opening for enabling a first fluid to pass into the second chamber (120) which is separated from the first chamber (110) by the membrane (130).Type: ApplicationFiled: September 23, 2010Publication date: January 3, 2013Inventors: Patrick Paullier, Aissa Ould Dris, Eric Leclerc