Abstract: A method and device are provided for guiding an aerodyne on the runway, picularly during the taxiing phase preceding take off, the device including an inertial unit adapted for delivering signals representative of the North speed, of the East speed, of the azimuth and of the ground speed of the aerodyne. From these signals, a computer elaborates a parameter defining the axis of the runway, during an apprenticeship step during which the aerodyne, guided on site by the pilot, taxies along the axis of the runway, and stores this parameter at the end of the step. The computer then delivers to the means piloting the aerodyne a synthetic runway aberration signal between the axis of the runway thus stored and the position of the aerodyne delivered by the inertial unit.