Patents by Inventor Patrick Powers
Patrick Powers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11633416Abstract: Oral formulations comprising a compound of Formula (I) and a chelating agent are provided, wherein compounds of Formula (I) have the structure: wherein, W, X, Y, Z, Ra, Rc, and each Rg are as defined herein. Also provided are methods of preparation, methods of use, and specific dosage forms.Type: GrantFiled: March 5, 2021Date of Patent: April 25, 2023Assignee: ARCUS BIOSCIENCES, INC.Inventors: Kenneth Victor Lawson, Manmohan Reddy Leleti, Jay Patrick Powers
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Patent number: 11499663Abstract: A water main tapping device and method includes a saddle body including an arcuate portion between a first end and a second end, wherein the saddle body includes a saddle opening at a location between the first end and the second end, and a corporation stop body formed integrally with and extending from the saddle body. The corporation stop body includes a base with an inlet cavity in fluid communication with the saddle opening, a housing extending from the base and having a valve cavity in which a rotatable valve is positioned and which is in fluid communication with the inlet cavity, and a connector end extending from the housing and including an outlet in fluid communication with the valve cavity.Type: GrantFiled: September 30, 2021Date of Patent: November 15, 2022Assignee: PowerSeal Pipeline ProductsInventor: Patrick Powers
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Patent number: 11433189Abstract: An aerosol delivery system has a nebulizer and a humidifier providing a gas flow to the nebulizer. A controller varies humidity level of the gas flow to the nebulizer so that if the nebulizer is not operating it has about 100% humidity and it is operating the value is less to allow for the humidification effect of the nebulizer. The control may be achieved by dynamically varying proportions of flow through a dry branch and a humidification branch.Type: GrantFiled: April 20, 2020Date of Patent: September 6, 2022Assignee: Stamford Devices LimitedInventor: Patrick Power
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Publication number: 20220273889Abstract: A nebuliser control device has a manually adjustable user interface and a cable extending from the interface to a power source, and a cable extending from the interface to an aerosol generator. The interface is manually adjustable by physical movement of an actuator such a slider or a rotating knob to locally control the operation of the aerosol generator.Type: ApplicationFiled: July 29, 2020Publication date: September 1, 2022Applicant: STAMFORD DEVICES LIMITEDInventors: Patrick POWER, Michael CASEY, Anthony REDMOND
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Publication number: 20220265940Abstract: A nebulizer device has an aerosol generator mounted in a housing, and a mouthpiece. The device is adapted for delivery of an active agent in an aerosol into the buccal cavity, with droplet size greater than 10 ?m. Aerosolization is started at or after the end of breath inhalation and is stopped at or before the start of breath inhalation. The flow is via mouthpiece with internal ridges which periodically narrow the flow path volume to so that droplets coalesce in the flow path before the mesh.Type: ApplicationFiled: July 23, 2020Publication date: August 25, 2022Applicant: STAMFORD DEVICES LIMITEDInventors: Colin TELFER, Patrick Power
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Patent number: 11407712Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.Type: GrantFiled: March 18, 2021Date of Patent: August 9, 2022Assignee: ARCUS BIOSCIENCES, INC.Inventors: Joel Worley Beatty, Samuel Lawrie Drew, Matthew Epplin, Jeremy Thomas Andre Fournier, Balint Gal, Tezcan Guney, Karl T. Haelsig, Clayton Hardman, Steven Donald Jacob, Jenna Leigh Jeffrey, Jaroslaw Kalisiak, Kenneth Victor Lawson, Manmohan Reddy Leleti, Erick Allen Lindsey, Artur Karenovich Mailyan, Debashis Mandal, Guillaume Mata, Hyunyoung Moon, Jay Patrick Powers, Brandon Reid Rosen, Yongli Su, Anh Thu Tran, Zhang Wang, Xuelei Yan, Kai Yu
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Publication number: 20220081665Abstract: The present invention concerns an improved bioreactor with enhanced oxygen transfer. In lieu of the standard impeller and sparger assembly, a rotating gas sparger is used to introduce oxygen into the reactor. A mechanical drive shaft is coupled to a conduit from which a length of tubing extends. A source of pressurized gas is fluidly coupled to the tubing, which tubing is rotated via the mechanical drive shaft. The rotating tubing has a variably sized outlet for introducing oxygen bubbles into the liquid medium of the reactor, the bubbles providing both mechanical agitation and oxygen transfer due to the rotation of the tubing.Type: ApplicationFiled: September 16, 2020Publication date: March 17, 2022Inventor: Patrick Power
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Patent number: 11267845Abstract: Compounds that modulate the conversion of AMP to adenosine by 5?-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5?-nucleotidase, ecto is also provided.Type: GrantFiled: November 17, 2017Date of Patent: March 8, 2022Assignee: ARCUS BIOSCIENCES, INC.Inventors: Jaroslaw Kalisiak, Kenneth V. Lawson, Manmohan Reddy Leleti, Erick Allen Lindsey, Dillon Harding Miles, Eric Newcomb, Jay Patrick Powers, Ehesan Ul Sharif
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Patent number: 11242319Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.Type: GrantFiled: November 5, 2015Date of Patent: February 8, 2022Assignee: Flexus Biosciences, Inc.Inventors: Hilary Plake Beck, Juan Carlos Jaen, Maksim Osipov, Jay Patrick Powers, Maureen Kay Reilly, Hunter Paul Shunatona, James Ross Walker, Mikhail Zibinsky, James Aaron Balog, David K. Williams, Weiwei Guo
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Patent number: 11236048Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.Type: GrantFiled: June 29, 2018Date of Patent: February 1, 2022Assignee: Bristol-Myers Squibb CompanyInventors: Albert J. Delmonte, Benjamin M. Cohen, Kenneth Joseph Fraunhoffer, Sergei Kolotuchin, Francisco Gonzalez-Bobes, Gregory Louis Beutner, Adam Joseph Freitag, Michael Scott Bultman, Yu Fan, Prantik Maity, Ian Scott Young, Hilary Plake Beck, Maksim Osipov, Jay Patrick Powers, Maureen Kay Reilly, Hunter Paul Shunatona, James Ross Walker, Mikhail Zibinsky
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Patent number: 11236049Abstract: The present disclosure relates to amorphous and crystalline forms of (R)-N-(4-chlorophenyl)-2-((1S,4S)-4-(6-fluoro-quinolin-4-yl) cyclohexyl)propanamide and its salts and hydrates, processes for their production, pharmaceutical compositions comprising them, and methods of treatment using them.Type: GrantFiled: June 29, 2018Date of Patent: February 1, 2022Assignee: Bristol-Myers Squibb CompanyInventors: Jay Patrick Powers, Hilary Plake Beck, Maksim Osipov, Maureen Kay Reilly, Hunter Paul Shunatona, James Ross Walker, Mikhail Zibinsky, Tamar Rosenbaum, Ian Scott Young, Jennifer Nelson, Petinka Vlahova
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Publication number: 20220018477Abstract: A water main tapping device and method includes a saddle body including an arcuate portion between a first end and a second end, wherein the saddle body includes a saddle opening at a location between the first end and the second end, and a corporation stop body formed integrally with and extending from the saddle body. The corporation stop body includes a base with an inlet cavity in fluid communication with the saddle opening, a housing extending from the base and having a valve cavity in which a rotatable valve is positioned and which is in fluid communication with the inlet cavity, and a connector end extending from the housing and including an outlet in fluid communication with the valve cavity.Type: ApplicationFiled: September 30, 2021Publication date: January 20, 2022Inventor: Patrick Powers
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Patent number: 11220492Abstract: A compound that is an inhibitor of at least one of the A2A and A2B adenosine receptors having Formula (I) and compositions containing the compound and methods for synthesizing the compound, are described herein. The use of such compound and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by the adenosine A2A receptor and/or the adenosine A2B receptor.Type: GrantFiled: May 16, 2018Date of Patent: January 11, 2022Assignee: ARCUS BIOSCIENCES, INC.Inventors: Manmohan Reddy Leleti, Dillon Harding Miles, Jay Patrick Powers, Brandon Reid Rosen, Ehesan Ul Sharif
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Patent number: 11216774Abstract: Systems and methods are disclosed for packing optimization and visualization.Type: GrantFiled: June 22, 2018Date of Patent: January 4, 2022Assignee: BENESHIP LLCInventors: Patrick Powers, James Malley
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Publication number: 20210269422Abstract: The present invention provides solid forms, solvates and hydrates of 3-[2-amino-6-(1-{[6-(2-hydroxypropan-2-yl)pyridine-2-yl]methyl}-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl]-2-methylbenzonitrile, and methods of making and using the same.Type: ApplicationFiled: July 17, 2019Publication date: September 2, 2021Inventors: Jenna Leigh Jeffrey, Manmohan Reddy Leleti, Dillon Harding Miles, Jay Patrick Powers
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Patent number: 11058704Abstract: Compounds that modulate the conversion of AMP to adenosine by 5?-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5?-nucleotidase, ecto is also provided.Type: GrantFiled: October 2, 2017Date of Patent: July 13, 2021Assignee: ARCUS BIOSCIENCES, INC.Inventors: Laurent Pierre Paul Debien, Jaroslaw Kalisiak, Kenneth V. Lawson, Manmohan Reddy Leleti, Erick Allen Lindsey, Dillon Harding Miles, Eric Newcomb, Jay Patrick Powers, Brandon Reid Rosen, Ehesan Ul Sharif
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Patent number: 11045472Abstract: Compounds of Formula I that inhibit at least one of the A2A and A2B adenosine receptors, and compositions containing compounds of Formula I and methods for synthesizing compounds of Formula I, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by the adenosine A2A receptor and/or the adenosine A2B receptor.Type: GrantFiled: May 3, 2018Date of Patent: June 29, 2021Assignee: ARCUS BIOSCIENCES, INC.Inventors: Manmohan Reddy Leleti, Dillon Harding Miles, Jay Patrick Powers, Brandon Reid Rosen, Ehesan Ul Sharif, Rhiannon Thomas-Tran
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Patent number: 11001603Abstract: Compounds that modulate the conversion of AMP to adenosine by 5?-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5?-nucleotidase, ecto is also provided.Type: GrantFiled: September 1, 2020Date of Patent: May 11, 2021Assignee: ARCUS BIOSCIENCES, INC.Inventors: Laurent Pierre Paul Debien, Juan Carlos Jaen, Jaroslaw Kalisiak, Kenneth V. Lawson, Manmohan Reddy Leleti, Erick Allen Lindsey, Dillon Harding Miles, Eric Newcomb, Jay Patrick Powers, Brandon Reid Rosen, Ehesan Ul Sharif
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Patent number: 10987322Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.Type: GrantFiled: June 5, 2015Date of Patent: April 27, 2021Assignee: Flexus Biosciences, Inc.Inventors: Juan Carlos Jaen, Maksim Osipov, Jay Patrick Powers, Hunter Paul Shunatona, James Ross Walker, Mikhail Zibinsky
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Patent number: 10981944Abstract: Compounds that modulate the conversion of AMP to adenosine by 5?-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5?-nucleotidase, ecto is also provided.Type: GrantFiled: February 12, 2019Date of Patent: April 20, 2021Assignee: ARCUS BIOSCIENCES, INC.Inventors: Laurent Pierre Paul Debien, Juan Carlos Jaen, Jaroslaw Kalisiak, Kenneth V. Lawson, Manmohan Reddy Leleti, Erick Allen Lindsey, Dillon Harding Miles, Eric Newcomb, Jay Patrick Powers, Brandon Reid Rosen, Ehesan Ul Sharif