Patents by Inventor Patrick Purcell
Patrick Purcell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20180230644Abstract: Engineered, reinforced leather materials (engineered leathers) including a composite of a fibrous matrix that has been tanned to allow crosslinking of the fibrous matrix to the collagen formed by cultured cells (e.g., fibroblasts). These engineered leathers may be referred to as fiber-reinforced biological tissue composites. Also described herein are methods of making such fiber-reinforced biological tissue composites.Type: ApplicationFiled: September 21, 2016Publication date: August 16, 2018Applicant: MODERN MEADOW, INC.Inventors: Brendan Patrick PURCELL, Gabor FORGACS
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Patent number: 10046053Abstract: The invention relates to compositions comprising (i) biocompatible hydrogel and (ii) one or more therapeutic agents contained within said hydrogel; wherein the hydrogel is cross-linked utilizing a cross-linker comprising a peptide sequence that is capable of being degraded by an enzyme; the therapeutic agent being effective as a treatment of a condition related to the presence of the enzyme.Type: GrantFiled: June 21, 2017Date of Patent: August 14, 2018Assignee: The Trustees of the University of PennsylvaniaInventors: Brendan Patrick Purcell, Jason Alan Burdick
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Patent number: 9919054Abstract: The invention relates to compositions comprising (i) biocompatible hydrogel and (ii) one or more therapeutic agents contained within said hydrogel; wherein the hydrogel is cross-linked utilizing a cross-linker comprising a peptide sequence that is capable of being degraded by an enzyme; the therapeutic agent being effective as a treatment of a condition related to the presence of the enzyme.Type: GrantFiled: May 22, 2017Date of Patent: March 20, 2018Assignee: The Trustees of the University of PennsylvaniaInventors: Jason Alan Burdick, Robert C. Gorman, Joseph H. Gorman, III, Brendan Patrick Purcell
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Publication number: 20180028672Abstract: The invention relates to compositions comprising (i) biocompatible hydrogel and (ii) one or more therapeutic agents contained within said hydrogel; wherein the hydrogel is cross-linked utilizing a cross-linker comprising a peptide sequence that is capable of being degraded by an enzyme; the therapeutic agent being effective as a treatment of a condition related to the presence of the enzyme.Type: ApplicationFiled: June 21, 2017Publication date: February 1, 2018Inventors: Brendan Patrick Purcell, Jason Alan Burdick
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Publication number: 20170258921Abstract: The invention relates to compositions comprising (i) biocompatible hydrogel and (ii) one or more therapeutic agents contained within said hydrogel; wherein the hydrogel is cross-linked utilizing a cross-linker comprising a peptide sequence that is capable of being degraded by an enzyme; the therapeutic agent being effective as a treatment of a condition related to the presence of the enzyme.Type: ApplicationFiled: May 22, 2017Publication date: September 14, 2017Inventors: Jason Alan Burdick, Robert C. Gorman, Joseph H. Gorman, III, Brendan Patrick Purcell
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Patent number: 9752122Abstract: Edible microcarriers, including microcarrier beads, microspheres and microsponges, appropriate for use in a bioreactor to culture cells that may be used to form a comestible engineered meat product. For example, the edible microcarriers described herein may include porous microcarriers that may be used to grow cells (e.g., smooth muscle cells) and may be included with the cells in the final engineered meat product, without requiring modification or removal of the cells from the microcarriers. In a particular example, the edible microcarriers may be formed of cross-linked pectin, such as pectin-thiopropionylamide (PTP), and RGD-containing polypeptide, such as thiolated cardosin A. Methods of forming edible microcarriers, methods of using the edible microcarriers to make engineered meat, and engineered meat including the edible microcarriers are also described herein.Type: GrantFiled: September 15, 2014Date of Patent: September 5, 2017Assignee: Modern Meadow, Inc.Inventors: Francoise Suzanne Marga, Brendan Patrick Purcell, Gabor Forgacs, Andras Forgacs
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Publication number: 20170233836Abstract: Biofabricated leathers made by electrocompaction and/or electrospsinning. Described herein are biofabricated leather materials derived from electrospun or electrocompacted collagen networks. These electrospun or electrocompacted leathers may have leather-like properties following and are may be processed as native leather and used to form leather goods.Type: ApplicationFiled: February 15, 2017Publication date: August 17, 2017Inventors: Karoly Robert JAKAB, Brendan Patrick PURCELL, David WILLIAMSON, Francoise Suzanne MARGA
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Publication number: 20170233944Abstract: A biofabricated material comprising a network of crosslinked collagen fibrils produced from recombinant collagen that contains substantially no 3-hydroxyproline residues is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability.Type: ApplicationFiled: February 15, 2017Publication date: August 17, 2017Applicant: MODERN MEADOW, INC.Inventors: Brendan Patrick PURCELL, David Thomas WILLIAMSON, Lixin DAI, Darryl Miles CASSINGHAM, Stephen M. SPINELLA, Amy CONGDON
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Publication number: 20170233838Abstract: A biofabricated material containing a network of crosslinked collagen fibrils is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability. It can have substantially identical grain, texture and other aesthetic properties on both sides distinct from natural leather where the grain increases from one side (e.g.Type: ApplicationFiled: February 15, 2017Publication date: August 17, 2017Applicant: MODERN MEADOW, INC.Inventors: Brendan Patrick PURCELL, David Thomas WILLIAMSON, Lixin DAI, Darryl Miles CASSINGHAM, Stephen M. SPINELLA
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Publication number: 20170233834Abstract: Described herein is a method for producing a biofabricated material from collagen or collagen-like proteins which are recombinantly produced and which contain substantially no 3-hydroxyproline. The collagen or collagen-like proteins are isolated from animal sources, or produced by recombinant DNA techniques or by chemical synthesis. The collagen or collagen-like proteins are fibrillated, crosslinked, dehydrated and lubricated thus forming the biofabricated material having a substantially uniform network of collagen fibrils.Type: ApplicationFiled: February 15, 2017Publication date: August 17, 2017Applicant: MODERN MEADOW, INCInventors: Brendan Patrick PURCELL, David Thomas Williamson, Francoise Suzanne Marga, Susan J. Schofer, Darryl Miles Cassingham, Stephen M. Spinella, Amy Congdon
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Publication number: 20170233837Abstract: The invention is directed to a composite material comprising a biofabricated material and a secondary component. The secondary component may be a porous material, such as a sheet of paper, cellulose, or fabric that has been coated or otherwise contacted with the biofabricated material. The biofabricated material comprises a uniform network of crosslinked collagen fibrils and provides strength, elasticity and an aesthetic appearance to the composite material.Type: ApplicationFiled: February 15, 2017Publication date: August 17, 2017Applicant: MODERN MEADOW, INC.Inventors: Brendan Patrick PURCELL, David Thomas Williamson, Suzanne Lee, Amy Congdon
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Publication number: 20170233945Abstract: The invention is directed to a method for producing a composite material comprising a biofabricated material and a secondary component. The secondary component may be a porous material, such as a sheet of paper, cellulose, or fabric that has been coated or otherwise contacted with the biofabricated material. The biofabricated material comprises a uniform network of crosslinked collagen fibrils and provides strength, elasticity and an aesthetic appearance to the composite material.Type: ApplicationFiled: February 15, 2017Publication date: August 17, 2017Applicant: MODERN MEADOW, INC.Inventors: Brendan Patrick PURCELL, David Thomas WILLIAMSON, Suzanne LEE, Amy CONGDON
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Publication number: 20170233536Abstract: Described herein is a method for producing a biofabricated material from collagen or collagen-like proteins. The collagen or collagen-like proteins are isolated from animal sources or produced by recombinant DNA techniques or by chemical synthesis. The collagen or collagen-like proteins are fibrillated, crosslinked, dehydrated and lubricated thus forming the biofabricated material having a substantially uniform network of collagen fibrils.Type: ApplicationFiled: February 15, 2017Publication date: August 17, 2017Applicant: MODERN MEADOW, INC.Inventors: Brendan Patrick PURCELL, David Thomas Williamson, Francoise Suzanne Marga, Susan J. Schofer, Darryl Miles Cassingham
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Publication number: 20170233537Abstract: The invention is directed to a composite material comprising a biofabricated material and a secondary component. The secondary component may be a porous material, such as a sheet of paper, cellulose, or fabric that has been coated or otherwise contacted with the biofabricated material. The biofabricated material comprises a uniform network of crosslinked collagen fibrils and provides strength, elasticity and an aesthetic appearance to the composite material.Type: ApplicationFiled: February 15, 2017Publication date: August 17, 2017Applicant: MODERN MEADOW, INC.Inventors: Brendan Patrick PURCELL, David Thomas Williamson, Suzanne Lee, Amy Congdon
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Publication number: 20170233943Abstract: The invention is directed to a composite material comprising a biofabricated material and a secondary component. The secondary component may be a porous material, such as a sheet of paper, cellulose, or fabric that has been coated or otherwise contacted with the biofabricated material. The biofabricated material comprises a uniform network of crosslinked collagen fibrilsand provides strength, elasticity and an aesthetic appearance to the composite material.Type: ApplicationFiled: February 15, 2017Publication date: August 17, 2017Applicant: MODERN MEADOW, INC.Inventors: Brendan Patrick PURCELL, David Thomas Williamson, Suzanne Lee, Amy Congdon
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Patent number: 9694081Abstract: The invention relates to compositions comprising (i) biocompatible hydrogel and (ii) one or more therapeutic agents contained within said hydrogel; wherein the hydrogel is cross-linked utilizing a cross-linker comprising a peptide sequence that is capable of being degraded by an enzyme; the therapeutic agent being effective as a treatment of a condition related to the presence of the enzyme.Type: GrantFiled: June 17, 2011Date of Patent: July 4, 2017Assignee: The Trustees Of The University Of PennsylvaniaInventors: Jason Alan Burdick, Robert C. Gorman, Joseph H. Gorman, III, Brendan Patrick Purcell
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Patent number: 9555401Abstract: A molecular sieve blend with improved performance characteristics produced by preparing or obtaining a hydrophilic zeolite, particularly a hydrophilic zeolite A with a low SiO2:Al2O3 ratio, preparing or obtaining a hydrophobic silicon based binder, particularly a hydrophobic colloidal silica or a hydrophobic siloxane based material, mixing the zeolite with the silicon based binder and, in one embodiment, a seed containing small quantities of a clay binding agent and the zeolite, to form a mixture, and forming the mixture into the molecular sieve blend.Type: GrantFiled: March 24, 2014Date of Patent: January 31, 2017Assignee: ZEOCHEM LLCInventors: Kerry Weston, Patrick Purcell
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Publication number: 20150079238Abstract: Edible microcarriers, including microcarrier beads, microspheres and microsponges, appropriate for use in a bioreactor to culture cells that may be used to form a comestible engineered meat product. For example, the edible microcarriers described herein may include porous microcarriers that may be used to grow cells (e.g., smooth muscle cells) and may be included with the cells in the final engineered meat product, without requiring modification or removal of the cells from the microcarriers. In a particular example, the edible microcarriers may be formed of cross-linked pectin, such as pectin-thiopropionylamide (PTP), and RGD-containing polypeptide, such as thiolated cardosin A. Methods of forming edible microcarriers, methods of using the edible microcarriers to make engineered meat, and engineered meat including the edible microcarriers are also described herein.Type: ApplicationFiled: September 15, 2014Publication date: March 19, 2015Inventors: Francoise Suzanne MARGA, Brendan Patrick PURCELL, Gabor FORGACS, Andras FORGACS
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Patent number: 8969633Abstract: A process for the production of a molecular sieve blend with improved performance characteristics produced by preparing or obtaining a hydrophilic zeolite, particularly a hydrophilic zeolite A with a low SiO2:Al2O3 ratio, preparing or obtaining a hydrophobic silicon based binder, particularly a hydrophobic colloidal silica or a hydrophobic siloxane based material, mixing the zeolite with the silicon based binder and, in one embodiment, a seed containing small quantities of a clay binding agent and the zeolite, to form a mixture, and forming the mixture into the molecular sieve blend.Type: GrantFiled: March 24, 2014Date of Patent: March 3, 2015Assignee: Zeochem LLCInventors: Kerry Weston, Patrick Purcell
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Publication number: 20140217324Abstract: A molecular sieve blend with improved performance characteristics produced by preparing or obtaining a hydrophilic zeolite, particularly a hydrophilic zeolite A with a low SiO2:Al2O3 ratio, preparing or obtaining a hydrophobic silicon based binder, particularly a hydrophobic colloidal silica or a hydrophobic siloxane based material, mixing the zeolite with the silicon based binder and, in one embodiment, a seed containing small quantities of a clay binding agent and the zeolite, to form a mixture, and forming the mixture into the molecular sieve blend.Type: ApplicationFiled: March 24, 2014Publication date: August 7, 2014Applicant: ZEOCHEM LLCInventors: Kerry Weston, Patrick Purcell