Patents by Inventor Patrick R. Charmley

Patrick R. Charmley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 19.5 polypeptide antibodies useful for diagnosing or treating psoriasis
    Patent number: 7879982
    Abstract: The present invention provides nucleic acid molecules, polypeptides, antibodies and methods for the diagnosis and/or treatment of psoriasis.
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: February 1, 2011
    Assignee: Celltech R&D, Inc.
    Inventors: Patrick R. Charmley, Ryan C. Smith, Rhodora H. Argonza-Barrett, Matthew P. Fitzgibbon, Kai Wang
  • Association of polymorphisms in the gene region with bone mineral density
    Patent number: 7799523
    Abstract: Compositions and methods are provided for determining in a subject a risk for having, or presence of, altered bone mineral density such as osteoporosis or osteopenia or other conditions characterized by decreased or increased bone density. Specifically, the invention relates to determination of a sclerostin gene region nucleotide polymorphism (SRP) in DNA of the sclerostin gene region of human chromosome 17. In certain embodiments, SRPs that indicate an increased risk for altered bone mineral density occur as gender-associated polymorphisms. Isolated polynucleotides comprising representative SRPs are also provided.
    Type: Grant
    Filed: April 3, 2003
    Date of Patent: September 21, 2010
    Assignee: Celltech R & D, Inc.
    Inventors: Bryan W. Paeper, Sean Proll, Patrick R. Charmley, Mary E. Brunkow, Andreas Gerardus Uitterlinden
  • Compositions and methods for diagnosing or treating psoriasis
    Patent number: 7622278
    Abstract: In one aspect, the present invention provides isolated nucleic acid molecules that encode a CAN-1 polypeptide, or an STG polypeptide. In another aspect, the present invention also provides isolated STG polypeptides, isolated CAN-1 polypeptides, and isolated SEEK-1 polypeptides. In another aspect, the present invention provides isolated antibodies that bind specifically to a CAN-1, SEEK-1 or STG polypeptide. In another aspect, the present invention provides methods of diagnosing or predicting the susceptibility to psoriasis of an individual. In another aspect, the present invention provides methods for ameliorating the symptoms and/or progression of psoriasis.
    Type: Grant
    Filed: July 9, 2008
    Date of Patent: November 24, 2009
    Assignee: UCB SA
    Inventors: Patrick R. Charmley, Patrick D. Moss, Mark D. McEuen
  • Antibodies for diagnosing psoriasis
    Patent number: 7585954
    Abstract: The present invention provides nucleic acid molecules, polypeptides, antibodies and methods for the diagnosis and/or treatment of psoriasis.
    Type: Grant
    Filed: April 19, 2005
    Date of Patent: September 8, 2009
    Assignee: UCB SA
    Inventors: Patrick R. Charmley, Ryan C. Smith, Rhodora H. Argonza-Barrett, Matthew P. Fitzgibbon, Kai Wang
  • Compositions and methods for diagnosing or treating psoriasis
    Publication number: 20090087439
    Abstract: In one aspect, the present invention provides isolated nucleic acid molecules that encode a CAN-1 polypeptide, or an STG polypeptide. In another aspect, the present invention also provides isolated STG polypeptides, isolated CAN-1 polypeptides, and isolated SEEK-1 polypeptides. In another aspect, the present invention provides isolated antibodies that bind specifically to a CAN-1, SEEK-1 or STG polypeptide. In another aspect, the present invention provides methods of diagnosing or predicting the susceptibility to psoriasis of an individual. In another aspect, the present invention provides methods for ameliorating the symptoms and/or progression of psoriasis.
    Type: Application
    Filed: July 9, 2008
    Publication date: April 2, 2009
    Applicant: UCB SA
    Inventors: Patrick R. Charmley, Patrick D. Moss, Mark D. McEuen
  • Compositions and methods for diagnosing or treating psoriasis
    Patent number: 6989247
    Abstract: In one aspect, the present invention provides isolated nucleic acid molecules that encode a CAN-1 polypeptide, or an STG polypeptide. In another aspect, the present invention also provides isolated STG polypeptides, isolated CAN-1 polypeptides, and isolated SEEK-1 polypeptides. In another aspect, the present invention provides isolated antibodies that bind specifically to a CAN-1, SEEK-1 or STG polypeptide. In another aspect, the present invention provides methods of diagnosing or predicting the susceptibility to psoriasis of an individual. In another aspect, the present invention provides methods for ameliorating the symptoms and/or progression of psoriasis.
    Type: Grant
    Filed: November 26, 2001
    Date of Patent: January 24, 2006
    Assignee: Celltech R & D, Inc.
    Inventors: Patrick R. Charmley, Patrick D. Moss, Mark D. McEuen
  • Association of polymorphisms in the SOST gene region with bone mineral density
    Publication number: 20030235847
    Abstract: Compositions and methods are provided for determining in a subject a risk for having, or presence of, altered bone mineral density such as osteoporosis or osteopenia or other conditions characterized by decreased or increased bone density. Specifically, the invention relates to determination of a sclerostin gene region nucleotide polymorphism (SRP) in DNA of the sclerostin gene region of human chromosome 17. In certain embodiments, SRPs that indicate an increased risk for altered bone mineral density occur as gender-associated polymorphisms. Isolated polynucleotides comprising representative SRPs are also provided.
    Type: Application
    Filed: April 3, 2003
    Publication date: December 25, 2003
    Applicants: Celltech R&D, Inc., Erasmus University Rotterdam
    Inventors: Bryan W. Paeper, Sean Proll, Patrick R. Charmley, Mary E. Brunkow, Andreas Gerardus Uitterlinden
  • Compositions and methods for diagnosing or treating psoriasis
    Publication number: 20020169127
    Abstract: The present invention provides nucleic acid molecules, polypeptides, antibodies and methods for the diagnosis and/or treatment of psoriasis.
    Type: Application
    Filed: March 28, 2002
    Publication date: November 14, 2002
    Inventors: Patrick R. Charmley, Ryan C. Smith, Rhodora H. Argonza-Barrett, Matthew P. Fitzgibbon, Kai Wang
  • Compositions and methods for diagnosing or treating psoriasis
    Publication number: 20020115148
    Abstract: In one aspect, the present invention provides isolated nucleic acid molecules that encode a CAN-1 polypeptide, or an STG polypeptide. In another aspect, the present invention also provides isolated STG polypeptides, isolated CAN-1 polypeptides, and isolated SEEK-1 polypeptides. In another aspect, the present invention provides isolated antibodies that bind specifically to a CAN-1, SEEK-1 or STG polypeptide. In another aspect, the present invention provides methods of diagnosing or predicting the susceptibility to psoriasis of an individual. In another aspect, the present invention provides methods for ameliorating the symptoms and/or progression of psoriasis.
    Type: Application
    Filed: November 26, 2001
    Publication date: August 22, 2002
    Applicant: Celltech R & D, Inc.
    Inventors: Patrick R. Charmley, Patrick D. Moss, Mark D. McEuen