Patents by Inventor Patrick Reed Maloney

Patrick Reed Maloney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of FXR ligands
    Patent number: 6984650
    Abstract: The present invention includes nuclear receptor heterodimer and nuclear receptor-coactivator peptide assays for identifying ligands for nuclear receptors, utilizing scintillation proximity and fluorescence resonance energy transfer (FRET), and methods of using identified ligands.
    Type: Grant
    Filed: August 8, 2003
    Date of Patent: January 10, 2006
    Assignee: Smithkline Beecham Corporation
    Inventors: Curt Dale Haffner, Patrick Reed Maloney, Timothy Mark Willson, Steven Gerard Blanchard, Steven A. Kliewer, Jurgen M. Lehmann, Derek James Parks, Julie Beth Stimmel
  • Activator of PPAR delta
    Patent number: 6723740
    Abstract: Compounds of Formula (I) are disclosed. These compounds selected activators of human PPAR delta.
    Type: Grant
    Filed: March 6, 2003
    Date of Patent: April 20, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Esther Yu-Hsuan Chao, Curt Dale Haffner, Millard Hurst Lambert, III, Patrick Reed Maloney, Michael Lawrence Sierra, Daniel David Sternbach, Marcos Luis Sznaidman, Timothy Mark Willson, Huaqiang Eric Xu
  • Substitued aminopropoxyaryl derivatives useful as agonists for lxr
    Publication number: 20040072868
    Abstract: 1
    Type: Application
    Filed: March 18, 2003
    Publication date: April 15, 2004
    Inventors: Jon Loren Collins, Adam M. Fivush, Patrick Reed Maloney, Eugene L. Stewart, Timothy Mark Willson
  • Activators of PPAR delta
    Patent number: 6710063
    Abstract: Compounds of Formula (1) are disclosed. These compounds include selective activators of human PPAR delta.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: March 23, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Esther Yu-Hsuan Chao, Curt Dale Haffner, Millard Hurst Lambert, III, Patrick Reed Maloney, Michael Lawrence Sierra, Daniel David Sternbach, Marcos Luis Sznaidman, Timothy Mark Willson, Huaqiang Eric Xu
  • Assays for ligands for nuclear receptors
    Publication number: 20040048316
    Abstract: The present invention includes nuclear receptor heterodimer and nuclear receptor-coactivator peptide assays for identifying ligands for nuclear receptors, utilizing scintillation proximity and fluorescence resonance energy transfer (FRET), and methods of using identified ligands.
    Type: Application
    Filed: August 8, 2003
    Publication date: March 11, 2004
    Inventors: Curt Dale Haffner, Patrick Reed Maloney, Timothy Mark Willson
  • Identification of new therapeutic targets for modulating bile acid synthesis
    Publication number: 20040038862
    Abstract: Abstract: Methods for identifying compounds that modulate bile acid synthesis by assessing their ability to act as ligands for short heterodimerizing partner-1 or liver receptor homologue-1 are provided. Also provided are compositions containing these ligands as well as methods for administering these compositions to modulate bile acid synthesis and cholesterol and lipid homeostasis.
    Type: Application
    Filed: January 28, 2003
    Publication date: February 26, 2004
    Inventors: Bryan James Goodwin, Stacey Ann Jones, Steven Anthony Kliewer, Patrick Reed Maloney
  • Activator of PPAR delta
    Publication number: 20030203947
    Abstract: Compounds of Formula (I) are disclosed. These compounds include selective activators of human PPAR delta.
    Type: Application
    Filed: March 6, 2003
    Publication date: October 30, 2003
    Inventors: Esther Yu-Hsuan Chao, Curt Dale Haffner, Millard Hurst Lambert, Patrick Reed Maloney, Michael Lawrence Sierra, Daniel David Sternbach, Marcos Luis Sznaidman, Timothy Mark Willson, Huaqiang Eric Xu
  • Assays for ligands for nuclear receptors
    Patent number: 6639078
    Abstract: The present invention includes nuclear receptor heterodimer and nuclear receptor-coactivator pepetide assays for identifying ligands for nuclear receptors, utilizing scintillation proximity and fluorescence resonance energy transfer (FRET), and methods of using identified ligands.
    Type: Grant
    Filed: June 18, 2001
    Date of Patent: October 28, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Curt Dare Haffner, Patrick Reed Maloney, Timothy Mark Wilson
  • Substituted 6-azaandrostenones
    Patent number: 5708001
    Abstract: The present invention relates to certain substituted 17.beta.-substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I), wherein R.sup.1 and R.sup.2 i) are independently hydrogen or lower alkyl and the bond between the carbons bearing R.sup.1 and R.sup.2 is a single or a double bond, or ii) taken together are a --CH.sub.2 -- group forming a cyclopropane ring, and the bond between the carbons bearing R.sup.1 and R.sup.2 is a single bond; R.sup.3 is preferably hydrogen, halogen or lower alkyl, R.sup.4 is preferably hydrogen or lower alkyl, X is preferably CH.sub.2, Y is preferably hydrogen and Z is preferably CONR.sup.14 R.sup.15 and R.sup.14 and R.sup.15 are a variety of organic groups, and pharmaceutically acceptable salts thereof, preparation, medical use and pharmaceutical formulations.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 13, 1998
    Assignee: Glaxo Wellcome Inc.
    Inventors: Robert Carl Andrews, Cynthia Markert Cribbs, Stephen Vernon Frye, Curt Dale Haffner, Patrick Reed Maloney