Abstract: A method of treating a cancer in a patient includes obtaining a sample from the patient, using a C-circle assay to detect a presence of an alternative lengthening of telomeres (ALT) phenotype in the sample, and administering an effect amount of at least one of PRIMA-1 or APR-246 to the patient.

Abstract: A system includes a handle with a hinge mechanism at a first end, the hinge mechanism including a lower hinge portion and an upper hinge portion rotatably coupled together. The handle also includes a rotary mechanism positioned at the first end and coupled to the lower hinge portion to enable circumferential movement of the lower end portion about a longitudinal axis of the handle. Additionally, a sensor arrangement is positioned within a body of the handle, the sensor arrangement measuring a number of rotations of the rotary mechanism about the longitudinal axis of the handle.

Abstract: A system includes a handle with a hinge mechanism at a first end, the hinge mechanism including a lower hinge portion and an upper hinge portion rotatably coupled together. The handle also includes a rotary mechanism positioned at the first end and coupled to the lower hinge portion to enable circumferential movement of the lower end portion about a longitudinal axis of the handle. Additionally, a sensor arrangement is positioned within a body of the handle, the sensor arrangement measuring a number of rotations of the rotary mechanism about the longitudinal axis of the handle.

Abstract: A system includes a handle with a hinge mechanism at a first end, the hinge mechanism including a lower hinge portion and an upper hinge portion rotatably coupled together. The handle also includes a rotary mechanism positioned at the first end and coupled to the lower hinge portion to enable circumferential movement of the lower end portion about a longitudinal axis of the handle. Additionally, a sensor arrangement is positioned within a body of the handle, the sensor arrangement measuring a number of rotations of the rotary mechanism about the longitudinal axis of the handle.

Abstract: A method of treating a cancer in a patient includes obtaining a sample from the patient, using a C-circle assay to detect a presence of an alternative lengthening of telomeres (ALT) phenotype in the sample, and administering an effect amount of at least one of PRIMA-1 or APR-246 to the patient.

Abstract: In various implementations, specific attributes found in images can be used in a visual-based search. Utilizing machine learning, deep neural networks, and other computer vision techniques, attributes of images, such as color, composition, font, style, and texture can be extracted from a given image. A user can then select a specific attribute from a sample image the user is searching for and the search can be refined to focus on that specific attribute from the sample image. In some embodiments, the search includes specific attributes from more than one image.

Abstract: In various implementations, one or more specific attributes found in an image can be modified utilizing one or more specific attributes found in another image. Machine learning, deep neural networks, and other computer vision techniques can be utilized to extract attributes of images, such as color, composition, font, style, and texture from one or more images. A user may modify at least one of these attributes in a first image based on the attribute(s) of another image and initiate a visual-based search using the modified image.

Abstract: A system for maintaining a repository replication system includes an interface and a processor. The interface is to receive a request to modify a repository, wherein the repository comprises repository copies. The processor is to determine whether modifying the repository resulted in an indication of an error, wherein the indication of the error is based at least in part on a plurality of checksums, wherein a checksum of the plurality of checksums is associated with a repository copy of the repository copies; and in the event that modifying the repository resulted in the indication of the error: queue a repair request to repair the error; and execute a repair process to repair the error associated with the repair request, wherein executing the repair process occurs asynchronously to queuing the error request.

Abstract: A system for directing reads includes an input interface and a processor. The input interface is to receive a request to read from a plurality of servers. The processor is to determine a set of weights for a set of healthy servers of the plurality of servers and determine a server to receive the request based at least in part on the set of weights.

Abstract: A system includes a handle with a hinge mechanism at a first end, the hinge mechanism including a lower hinge portion and an upper hinge portion rotatably coupled together. The handle also includes a rotary mechanism positioned at the first end and coupled to the lower hinge portion to enable circumferential movement of the lower end portion about a longitudinal axis of the handle. Additionally, a sensor arrangement is positioned within a body of the handle, the sensor arrangement measuring a number of rotations of the rotary mechanism about the longitudinal axis of the handle.

Abstract: A system for command handling for replicated repositories includes an input interface and a processor. The input interface is to receive a command. The processor is to determine a set of servers to receive the command, determine whether responses match for the command for each server of the set of server, and in the event the responses do not match, determine whether the responses are required to match for the command and in the event the responses are not required to match for the command, determine a unified response.

Abstract: A system for directing reads includes an input interface and a processor. The input interface is to receive a request to read from a plurality of servers. The processor is to determine a set of weights for a set of healthy servers of the plurality of servers and determine a server to receive the request based at least in part on the set of weights.

Abstract: A method of treating a hyperproliferative disorder in a subject in need of such treatment, comprising administering to said subject, in combination, a treatment effective amount of: (a) a ceramide-increasing retinoid such as fenretinide or a pharmaceutically acceptable salt thereof; and (b) at least one (and in certain embodiments at least two) compounds selected from the groups consisting of (i) a non-18 carbon chain length L-threo-sphinganine(s) or pharmaceuticeutically acceptable salt thereof, (ii) glucosylceramide or glucosyl(dihydro)ceramide synthesis inhibitor(s), and (iii) sphingomyelin or dihydrosphingomyelin synthase inhibitor(s). Preferred L-threo-sphinganines are of carbon chain length 17 carbons, 19 carbons and 20 carbons. A preferred glucosylceramide or glucosyl(dihydro)ceramide synthesis inhibitor IS D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol. A preferred sphingomyelin or dihydrosphingomyelin synthesis inhibitor is D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol.

Abstract: A system for maintaining a repository replication system includes an interface and a processor. The interface is to receive a request to modify a repository, wherein the repository comprises repository copies. The processor is to determine whether modifying the repository resulted in an indication of an error, wherein the indication of the error is based at least in part on a plurality of checksums, wherein a checksum of the plurality of checksums is associated with a repository copy of the repository copies; and in the event that modifying the repository resulted in the indication of the error: queue a repair request to repair the error; and execute a repair process to repair the error associated with the repair request, wherein executing the repair process occurs asynchronously to queuing the error request.

Abstract: A system for directing reads includes an input interface and a processor. The input interface is to receive a request to read from a plurality of servers. The processor is to determine a set of weights for a set of healthy servers of the plurality of servers and determine a server to receive the request based at least in part on the set of weights.

Abstract: A system for a distributed repository includes an input interface and a processor. The input interface is to receive a request to change a portion of code. The processor is to determine a change reference and an existing reference, indicate to lock one or more repositories, determine whether swapping references is approved by a vote, and in the event that swapping references is approved by a vote, swap the references and indicate to unlock the one or more repositories.

Abstract: A system for maintaining a repository replication system includes an interface and a processor. The interface is to receive a request to modify a repository, wherein the repository comprises repository copies. The processor is to determine whether modifying the repository resulted in an indication of an error, wherein the indication of the error is based at least in part on a plurality of checksums, wherein a checksum of the plurality of checksums is associated with a repository copy of the repository copies; and in the event that modifying the repository resulted in the indication of the error: queue a repair request to repair the error; and execute a repair process to repair the error associated with the repair request, wherein executing the repair process occurs asynchronously to queuing the error request.

Abstract: A system for a distributed repository includes an input interface and a processor. The input interface is to receive a request to change a portion of code. The processor is to determine a change reference and an existing reference, indicate to lock one or more repositories, determine whether swapping references is approved by a vote, and in the event that swapping references is approved by a vote, swap the references and indicate to unlock the one or more repositories.

Abstract: A system for a distributed repository includes an input interface and a processor. The input interface is to receive a request to change a portion of code. The processor is to determine a change reference and an existing reference, indicate to lock one or more repositories, determine whether swapping references is approved by a vote, and in the event that swapping references is approved by a vote, swap the references and indicate to unlock the one or more repositories.

Abstract: Methods for characterizing a beam parameter associated with an electromagnetic beam of a light source. The light source exposes a phase-shifted target through a set of focal distances relative to a focal plane of a substrate. At each focal distance of the set, registration values are measured and used to determine one or more registration slopes as a function of focal distance. The registration slopes are compared with baseline registration slopes to characterize the current relative state of the beam parameter in question. Beam parameters that may be characterized in this manner include degree of polarization and polarization rotation relative to an initial polarization direction. Phase shift test patterns advantageously used for beam characterization are described.