Abstract: It is disclosed herein that ssAAV and scAAV vectors of the same serotype administered by injection into the cerebrospinal fluid (CSF) via the intracerebroventricular (ICV) or intrathecal (cisternal or lumbar) route exhibit different cellular tropisms in the central nervous system. Thus, a subject can be treated by injection into the CSF of ssAAV or scAAV vector encoding a therapeutic protein, such as an ssAAV9 or scAAV9 vector. The therapeutic protein can be targeted to specific cells using these vectors. In some embodiments, scAAV9 is utilized to achieve superior transduction in the hippocampus, cerebellum and cerebral cortex where both neurons, particularly Purkinje neurons, and glial cells (such as astrocytes) are transduced. In other embodiments, ssAAV9 is utilized to minimize transduction of astrocytes. In further embodiments, an immunosuppressive agent is also administered to the subject.

Abstract: A system and method for updating user information includes a first device with first circuitry. The first circuitry is configured to generate motion data of the first device, and receive time-stamped location data of the first device from at least one communication device based on the generated motion data. The first circuitry is further configured to generate time synchronized user data based on the time-stamped location data and device data of the first device, and transmit the time synchronized user data. The system further comprises a second device communicably coupled to the first device. The second device comprises second circuitry configured to receive the time synchronized user data and update the user information based on the time synchronized user data.

Abstract: Abstract: The present disclosure relates, in general, to muteins of IL-10 that are stable as monomers, antigen binding proteins that bind to TREM-1, and antigen binding proteins comprising IL-10 muteins and antigen binding moieties, e.g., anti-TREM-1 antibodies, and compositions thereof. The disclosure also provides methods of treating inflammatory disease, such as inflammatory bowel disease or ulcerative colitis, using the compositions.

Abstract: A system and method for updating user information includes a first device with first circuitry. The first circuitry is configured to generate motion data of the first device, and receive time-stamped location data of the first device from at least one communication device based on the generated motion data. The first circuitry is further configured to generate time synchronized user data based on the time-stamped location data and device data of the first device, and transmit the time synchronized user data. The system further comprises a second device communicably coupled to the first device. The second device comprises second circuitry configured to receive the time synchronized user data and update the user information based on the time synchronized user data.

Abstract: A method of forming a molded interconnect device (MID) is provided. The method includes the steps of performing a molding stage, performing a circuit forming stage, and performing a plate stage. As a part of the molding stage, a palladium-catalyzed material is injection molded into a palladium-catalyzed substrate of a desired shape. As a part of the circuit forming stage, both a metallization step and a circuit patterning step are performed. As a part of the plating stage, both an electrolytic plating step and a circuit isolation step are performed.

Abstract: An augmented reality experience is provided to a user of a hand held device, such as a mobile phone, which incorporates an electronic processor, a camera and a display. Images taken from video footage are displayed in a display of a hand held device together with a live camera view, to create the illusion that the subject of the video—i.e., the virtual moving image—is present in the field of view of the camera in real time. In this context the term “real world” image means an image taken from reality, such as a physical, real-world scenario using an electronic photo-capture technique, e.g. video recording. A camera of a hand held device is aimed at a well-known object, which is recognisable to the device. A moving virtual image of an actor playing the part of an historical figure, chosen because of its relevance to the object, is displayed.

Abstract: A live broadcast is depicted, in this case a golf tournament. The broadcast is depicted on a television screen of a user, substantially in real time. In a television studio, which may be close to the site of the live broadcast, or may be remote therefrom, a commentator or pundit records segments of video analysis. The video image is sent to a server. The video clip of the commentator is then downloadable by the user using a device such as a mobile phone or tablet. The user can then view the additional content—the video segment of the commentator—on his device. Using the techniques of positioning and anchoring as described herein, the user can enjoy the video segment as though the commentator were present in the room, by viewing the room through a camera of the device.

Abstract: A first non-volatile dual in-line memory module (NVDIMM) of a first server and a second NVDIMM of a second server are armed during initial program load in a dual-server based storage system to configure the first NVDIMM and the second NVDIMM to retain data on power loss. Prior to initiating a safe data commit scan to destage modified data from the first server to a secondary storage, a determination is made as to whether the first NVDIMM is armed. In response to determining that the first NVDIMM is not armed, a failover is initiated to the second server.

Abstract: In some embodiments, a manufacturing process includes injection molding a palladium-catalyzed material into a substrate, forming a thin copper film over exterior and exposed surfaces of the substrate; ablating or removing copper film from the substrate to provide first, second and optional third portions of the copper film and ablated sections; electrolytically plating each portion to form metallic-plated portions; and ablating or removing the second portion in order to isolate the first portion. The metallic-plated first portion comprises a circuit portion of a molded interconnect device (MID), and where the metallic-plated third portion comprises a Faraday cage portion of a MID. A soft etching step may be included. A solder resist application step can be added, along with an associated solder resist removal step.

Abstract: A system and method for controlling transmission of contextual data includes at least one non-transitory memory configured to store computer program code instructions; and at least one processor configured to execute the computer program code instructions. The processor is configured to receive location data of a first device, and to obtain connection data corresponding to a connection between the first device and at least a second device and to time data associated with the connection data, based on the location data. The processor is also configured to determine the contextual data corresponding to the first device, based on the time data associated with the connection data; and control transmission of the contextual data from the first device to the at least one second device, based on the connection data.

Abstract: An apparatus system and method for processing patient data pursuant to a monitoring period, wherein received patient feedback data is processed and structured to provide a selectable keyword cloud to a display. The keyword cloud may include a plurality of at least one of symptoms, complications and patient conditions, wherein the keyword cloud is structured by a processor for display in accordance with previous patient feedback data during at least part of the monitoring period.

Abstract: An augmented reality experience is provided to a user of a hand held device, such as a mobile phone, which incorporates an electronic processor, a camera and a display. Images taken from video footage are displayed in a display of a hand held device together with a live camera view, to create the illusion that the subject of the video—i.e., the virtual moving image—is present in the field of view of the camera in real time. In this context the term “real world” image means an image taken from reality, such as a physical, real-world scenario using an electronic photo-capture technique, e.g. video recording. A camera of a hand held device is aimed at a well-known object, which is recognisable to the device. A moving virtual image of an actor playing the part of an historical figure, chosen because of its relevance to the object, is displayed.

Abstract: A first non-volatile dual in-line memory module (NVDIMM) of a first server and a second NVDIMM of a second server are armed during initial program load in a dual-server based storage system to configure the first NVDIMM and the second NVDIMM to retain data on power loss. Prior to initiating a safe data commit scan to destage modified data from the first server to a secondary storage, a determination is made as to whether the first NVDIMM is armed. In response to determining that the first NVDIMM is not armed, a failover is initiated to the second server.

Abstract: An augmented reality experience is provided to a user of a hand held device, such as a mobile phone, which incorporates an electronic processor, a camera and a display. In particular, images taken from video footage are displayed in a display of a hand held device together with a live camera view, to create the illusion that the subject of the video—ie the virtual moving image—is present in the field of view of the camera in real time. In this context the term “real world” image means an image taken from reality, such as a physical, real-world scenario using an electronic photo-capture technique, e.g. video recording. A camera 10 of a hand held device is aimed at a well-known object 12, which is recognisable to the device. A moving virtual image 14 of an actor playing the part of an historical figure, chosen because of its relevance to the object 12, is displayed.

Abstract: A live broadcast is depicted, in this case a golf tournament. The broadcast is depicted on a television screen of a user, substantially in real time. In a television studio, which may be close to the site of the live broadcast, or may be remote therefrom, a commentator or pundit records segments of video analysis. The video image is sent to a server. The video clip of the commentator is then downloadable by the user using a device such as a mobile phone or tablet. The user can then view the additional content—the video segment of the commentator—on his device. Using the techniques of positioning and anchoring as described herein, the user can enjoy the video segment as though the commentator were present in the room, by viewing the room through a camera of the device.

Abstract: At (400) a live broadcast is depicted, in this case a golf tournament. The broadcast (400) is depicted on a television screen (410) of a user (420), substantially in real time. In a television studio, represented by (430), which may be close to the site of the live broadcast, or may be remote therefrom, a commentator or pundit (440) records segments of video analysis. The video image is sent to a server (450). The video clip of the commentator (440) is then downloadable by the user (420) using a device such as a mobile phone or tablet (460). The user can then view the additional content—the video segment of the commentator (440)—on his (device 460). Using the techniques of positioning and anchoring as described herein, the user (420) can enjoy the video (segment 440) as though the commentator were present in the room, by viewing the room through a camera of the device (460).

Abstract: An end cap for a gas assist strut according to an exemplary aspect of the present disclosure includes, among other things, a body providing a socket, a spring clip having ends projecting into the socket, and a lever. The lever is arranged such that application of pressure to the lever draws the ends of the spring away from one another. This disclosure also relates to a motor vehicle including the subject end cap. A method is also disclosed.

Abstract: A method of providing an augmented reality image comprises recording a basic image including a subject and a first background using a recording device, extracting a subject image from the basic image, and providing the extracted subject image to a display device for combining with a second background. At A the sending person using the app to record a moving image of their own head—ie a video—which is separated from the background by the app (the background being automatically discarded). The image is then sent to a recipient who, at B, sees the head speak to them either on their desktop or in the camera view of the smart phone/tablet if they so choose.

Abstract: Embodiments herein relate to an electronic device that includes a camera sensor to capture a digital image that includes a plurality of pixels. The electronic device may further include a digital signature calculation engine coupled with the camera sensor, the digital signature calculation engine to generate, based on a private key that is shared between a plurality of image/video acquisition modules and a pixel of the plurality of pixels, a digital signature. The electronic device may further include digital signature insertion logic coupled with the digital signature calculation engine, the digital signature insertion logic to insert an indication of the digital signature into the digital image. Other embodiments may be described and/or claimed.

Abstract: An apparatus system and method for processing patient data pursuant to a monitoring period, wherein received patient feedback data is processed and structured to provide a selectable keyword cloud to a display. The keyword cloud may include a plurality of at least one of symptoms, complications and patient conditions, wherein the keyword cloud is structured by a processor for display in accordance with previous patient feedback data during at least part of the monitoring period.