Patents by Inventor Patrick S. Doyle

Patrick S. Doyle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190154679
    Abstract: Apparatuses and methods for cell and tissue assays and agent delivery are generally described.
    Type: Application
    Filed: November 14, 2018
    Publication date: May 23, 2019
    Applicants: Massachusetts Institute of Technology, Beth Israel Deaconess Medical Center
    Inventors: Patrick S. Doyle, Augusto M. Tentori, Maxwell Benjamin Nagarajan, Jae Jung Kim, Wen Cai Zhang, Frank J. Slack
  • Patent number: 9937495
    Abstract: Techniques for hydrogel microstructures with oil isolation for small reaction volumes include providing a hydrogel microstructure that has a plurality of pores and a hydrogel frame surrounding the pores. The microstructure has a volume in a range from about 1 picoliter to about 10,000 picoliters and is configured to repel an immiscible fluid. Each pore of the plurality of pores has a pore size configured to pass the target molecule in a first solution. The microstructure is contacted with the first solution, and with a second solution that includes a reactant molecule that reacts with the target molecule to produce an observable product molecule. The microstructure is encompassed with the immiscible fluid for an extended observation duration from about 1 to about 10,000 seconds, wherein the immiscible fluid does not pass into the pores but traps the product in the microstructure. The observable product molecule is measured at some time during the observation duration.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: April 10, 2018
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Rathi Lakshmi Srinivas, Patrick S. Doyle
  • Publication number: 20180071215
    Abstract: Compositions, methods, and systems for controlling crystallization of an agent are generally described. In some embodiments, an agent is crystallized in the presence of polymer matrices, such as polymer particles. The polymer matrix may influence at least a portion of the crystallization process and/or the resulting composition. In some such embodiments, the polymer matrix allows one or more aspect of the process and/or composition to be controlled and/or altered. For instance, the polymer matrix may act as a crystallization promoter and/or acceptable carriers of the crystallized agent. In certain embodiments, the polymer matrix described herein, can be used with any agent regardless of its chemical and/or physical properties.
    Type: Application
    Filed: September 22, 2017
    Publication date: March 15, 2018
    Applicant: Massachusetts Institute of Technology
    Inventors: Bernhardt Levy Trout, Patrick S. Doyle, Allan S. Myerson, Paul Douglas Godfrin, Abu Zayed Md Badruddoza
  • Publication number: 20170226417
    Abstract: Hydrogel microparticles spatially and spectrally encoded using upconverting phosphor nanoparticles are described for use in biochemical testing. In each microparticle, upconversion nanocrystals having spectrally distinguishable emission spectra are disposed in different partions of an encoding region of the microparticle.
    Type: Application
    Filed: December 22, 2016
    Publication date: August 10, 2017
    Inventors: Paul Bisso, Albert Swiston, Jiseok Lee, Patrick S. Doyle
  • Publication number: 20170226416
    Abstract: Polymer microparticles spatially and spectrally encoded using upconversion nanocrystals (UCN) are described for labeling of articles and tissues. UCN having spectrally distinguishable emission spectra are disposed in different portions of an encoding region of each microparticle.
    Type: Application
    Filed: December 22, 2016
    Publication date: August 10, 2017
    Inventors: Paul Bisso, Albert Swiston, Jiseok Lee, Patrick S. Doyle
  • Patent number: 9528145
    Abstract: Hydrogel microparticles spatially and spectrally encoded using upconverting phosphor nanoparticles are described for use in biochemical testing. In each microparticle, upconversion nanocrystals having spectrally distinguishable emission spectra are disposed in different pardons of an encoding region of the microparticle.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: December 27, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: Paul Bisso, Albert Swiston, Jiseok Lee, Patrick S. Doyle
  • Patent number: 9528144
    Abstract: Polymer microparticles spatially and spectrally encoded using upconversion nanocrystals (UCN) are described for labeling of articles and tissues. UCN having spectrally distinguishable emission spectra are disposed in different portions of an encoding region of each microparticle.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: December 27, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: Paul Bisso, Albert Swiston, Jiseok Lee, Patrick S. Doyle
  • Publication number: 20160129019
    Abstract: The present invention generally relates to compositions, methods, and systems relating to controlled crystallization and/or nucleation of a molecular species. In some embodiments, the crystallization and/or nucleation of the molecular species may be controlled by tuning the surface chemistry and/or the morphology of a crystallization substrate. In some embodiments, the molecular species is a small organic molecule (e.g., pharmaceutically active agent).
    Type: Application
    Filed: July 24, 2015
    Publication date: May 12, 2016
    Inventors: Bernhardt Levy Trout, Patrick S. Doyle, Trevor Alan Hatton, Allan Stuart Myerson, Ying Diao, Matthew E. Helgeson
  • Patent number: 9310361
    Abstract: Method for making multifunctional particles. The method includes flowing a first monomer stream loaded with a fluorescent entity along a microfluidic channel and flowing a second monomer stream loaded with a probe adjacent to the first monomer stream along the microfluidic channel. The monomer streams are polymerized to synthesize particles having a fluorescent, graphically encoded region and a probe-loaded region.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: April 12, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: Patrick S. Doyle, Daniel C. Pregibon
  • Patent number: 9138659
    Abstract: The present invention generally relates to compositions, methods, and systems relating to controlled crystallization and/or nucleation of a molecular species. In some embodiments, the crystallization and/or nucleation of the molecular species may be controlled by tuning the surface chemistry and/or the morphology of a crystallization substrate. In some embodiments, the molecular species is a small organic molecule (e.g., pharmaceutically active agent).
    Type: Grant
    Filed: August 23, 2011
    Date of Patent: September 22, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Bernhardt Levy Trout, Patrick S. Doyle, Trevor Alan Hatton, Allan Stuart Myerson, Ying Diao, Matthew E. Helgeson
  • Publication number: 20150196489
    Abstract: Compositions, methods, and systems for controlling crystallization of an agent are generally described. In some embodiments, an agent is crystallized in the presence of polymer matrices, such as polymer particles. The polymer matrix may influence at least a portion of the crystallization process and/or the resulting composition. In some such embodiments, the polymer matrix allows one or more aspect of the process and/or composition to be controlled and/or altered. For instance, the polymer matrix may act as a crystallization promoter and/or acceptable carriers of the crystallized agent. In certain embodiments, the polymer matrix described herein, can be used with any agent regardless of its chemical and/or physical properties.
    Type: Application
    Filed: December 18, 2014
    Publication date: July 16, 2015
    Applicant: Massachusetts Institute of Technology
    Inventors: Huseyin Burak Eral, Vilmali Lopez-Mejias, Allan Stuart Myerson, Bernhardt Levy Trout, Patrick S. Doyle, Marcus O'Mahony
  • Publication number: 20150119280
    Abstract: Techniques for hydrogel microstructures with oil isolation for small reaction volumes include providing a hydrogel microstructure that has a plurality of pores and a hydrogel frame surrounding the pores. The microstructure has a volume in a range from about 1 picoliter to about 10,000 picoliters and is configured to repel an immiscible fluid. Each pore of the plurality of pores has a pore size configured to pass the target molecule in a first solution. The microstructure is contacted with the first solution, and with a second solution that includes a reactant molecule that reacts with the target molecule to produce an observable product molecule. The microstructure is encompassed with the immiscible fluid for an extended observation duration from about 1 to about 10,000 seconds, wherein the immiscible fluid does not pass into the pores but traps the product in the microstructure. The observable product molecule is measured at some time during the observation duration.
    Type: Application
    Filed: October 27, 2014
    Publication date: April 30, 2015
    Applicant: Massachusetts Institute of Technology
    Inventors: Rathi Lakshmi Srinivas, Patrick S. Doyle
  • Publication number: 20140273255
    Abstract: Hydrogel microparticles spatially and spectrally encoded using upconverting phosphor nanoparticles are described for use in biochemical testing. In each microparticle, upconversion nanocrystals having spectrally distinguishable emission spectra are disposed in different pardons of an encoding region of the microparticle.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Paul Bisso, Albert Swiston, Jiseok Lee, Patrick S. Doyle
  • Publication number: 20140273246
    Abstract: Polymer microparticles spatially and spectrally encoded using upconversion nanocrystals (UCN) are described for labeling of articles and tissues. UCN having spectrally distinguishable emission spectra are disposed in different portions of an encoding region of each microparticle.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Paul Bisso, Albert Swiston, Jiseok Lee, Patrick S. Doyle
  • Publication number: 20120076860
    Abstract: The present invention generally relates to compositions, methods, and systems relating to controlled crystallization and/or nucleation of a molecular species. In some embodiments, the crystallization and/or nucleation of the molecular species may be controlled by tuning the surface chemistry and/or the morphology of a crystallization substrate. In some embodiments, the molecular species is a small organic molecule (e.g., pharmaceutically active agent).
    Type: Application
    Filed: August 23, 2011
    Publication date: March 29, 2012
    Applicant: Massachusetts Institute of Technology
    Inventors: Bernhardt Levy Trout, Patrick S. Doyle, Trevor Alan Hatton, Allan Stuart Myerson, Ying Diao, Matthew E. Helgeson
  • Publication number: 20110263747
    Abstract: Method for making multifunctional particles. The method includes flowing a first monomer stream loaded with a fluorescent entity along a microfluidic channel and flowing a second monomer stream loaded with a probe adjacent to the first monomer stream along the microfluidic channel. The monomer streams are polymerized to synthesize particles having a fluorescent, graphically encoded region and a probe-loaded region.
    Type: Application
    Filed: April 8, 2011
    Publication date: October 27, 2011
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Patrick S. Doyle, Daniel C. Pregibon
  • Patent number: 7947487
    Abstract: Method for making multifunctional particles. The method includes flowing a first monomer stream loaded with a fluorescent entity along a microfluidic channel and flowing a second monomer stream loaded with a probe adjacent to the first monomer stream along the microfluidic channel. The monomer streams are polymerized to synthesize particles having a fluorescent, graphically encoded region and a probe-loaded region.
    Type: Grant
    Filed: October 4, 2007
    Date of Patent: May 24, 2011
    Assignee: Massachusetts Institute of Technology
    Inventors: Patrick S. Doyle, Daniel C. Pregibon
  • Publication number: 20100172898
    Abstract: In a method for synthesizing polymeric microstructures, a monomer stream is flowed, at a selected flow rate, through a fluidic channel. At least one shaped pulse of illumination is projected to the monomer stream, defining in the monomer stream a shape of at least one microstructure corresponding to the illumination pulse shape while polymerizing that microstructure shape in the monomer stream by the illumination pulse. An article of manufacture includes a non-spheroidal polymeric microstructure that has a plurality of distinct material regions.
    Type: Application
    Filed: March 15, 2010
    Publication date: July 8, 2010
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Patrick S. DOYLE, Daniel C. PREGIBON, Dhananjay DENDUKURI
  • Patent number: 7709544
    Abstract: In a method for synthesizing polymeric microstructures, a monomer stream is flowed, at a selected flow rate, through a fluidic channel. At least one shaped pulse of illumination is projected to the monomer stream, defining in the monomer stream a shape of at least one microstructure corresponding to the illumination pulse shape while polymerizing that microstructure shape in the monomer stream by the illumination pulse.
    Type: Grant
    Filed: October 25, 2006
    Date of Patent: May 4, 2010
    Assignee: Massachusetts Institute of Technology
    Inventors: Patrick S. Doyle, Daniel C. Pregibon, Dhananjay Dendukuri
  • Publication number: 20080176216
    Abstract: Method for making multifunctional particles. The method includes flowing a first monomer stream loaded with a fluorescent entity along a microfluidic channel and flowing a second monomer stream loaded with a probe adjacent to the first monomer stream along the microfluidic channel. The monomer streams are polymerized to synthesize particles having a fluorescent, graphically encoded region and a probe-loaded region.
    Type: Application
    Filed: October 4, 2007
    Publication date: July 24, 2008
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Patrick S. Doyle, Daniel C. Pregnibon