Abstract: The invention provides an adaptable smoking device having separable upper and lower portions that facilitate travel, filling the device with water, cleaning, and the replacement of the upper or lower portion of the device in the event of breaking or chipping. The upper and lower portions can be separably connected to one another by two or more connectors. The connectors can comprise magnets or a magnet and a ferromagnetic metal.

Abstract: The present invention relates to an immunoreactive molecule that specifically recognises and binds to human Ankyrin Repeat Domain-Containing Protein 30A (NY-BR-1) and, in particular, to an immunoreactive molecule, which shows no cross-reactivity to other human Ankyrin repeat domain containing proteins. The invention further relates to the use of such immunoreactive molecules in the treatment of cancer as well as in companion diagnostics methods.

Abstract: Illumination device for a motor vehicle headlight. The device has a light source, a light-permeable body (LPB), a light injection element for injecting light from the light source into the LPB, and a projection device. Light from the light source forms a light distribution with a cut-off line formed by a screen edge of a screen device, which is formed by a boundary surface of the LPB. A sign light light source (SLLS) and a further sign light light injection element (SLLIE) associated with the SLLS are provided. The SLLIE forms the light emitted by the SLLS into a third light beam and directs the third light beam onto the boundary surface, which re-enter the LPB and are projected by the projection optics device as a sign light light beam into a region of the light distribution lying above the cut-off line and are displayed as sign light light distribution.

Abstract: A microscopy system and method of focusing the same are disclosed herein. The microscopy system may include an objective, and imaging device, an illumination source, an epi-illumination module, and a controller. The imaging device is configured to capture a single image of a specimen positioned on a stage of the microscopy system. The illumination source is configured to illuminate the specimen positioned on the stage. The epi-illumination module includes a focusing mechanism in a first primary optical path of a light generated by the illumination source. The focusing mechanism is tilted in relation to a plane perpendicular to the first primary optical path. The controller is in communication with the illumination source. The controller is configured to focus the microscopy system based on a pattern produced by the focusing mechanism on the single image captured by the imaging device.

Abstract: An optical device (1) for a motor vehicle, for projecting a graphic element into a region in front of the optical device. The device includes a laser light source (2), an infrared light source (3), a light guiding device (4), an infrared detector (5), a time-of-flight sensor device (6), and a control device (7), wherein the light guiding device is configured to produce a light distribution with laser light from the laser light source and to form an infrared light beam from infrared light from the infrared light source, wherein the infrared detector is configured to detect reflected infrared light from a measurement object and send a first sensor signal, wherein the sensor device is configured to detect a measurement object and send a second sensor signal, wherein the control device is configured to change the light distribution depending on the first sensor signal and the second sensor signal.

Abstract: A bicycle battery assembly comprises a bicycle frame tube, such as a down tube. A battery is adapted to be inserted through a battery opening in the longitudinal direction of the bicycle frame tube. For allowing for a simple fixing of the battery to the bicycle frame tube, in particular by means of screws, an installation aid is connected to the battery and/or the bicycle frame tube, in particular in the area of the battery opening. The installation aid allows for an easy installation since in particular screw holes in the bicycle frame tube are flush with threaded bore holes in the battery.

Abstract: A lighting device for a vehicle headlamp includes a plurality of light sources; a first lens element (FLE) downstream of the light sources; and a second lens element (SLE) downstream of the FLE. A light receiving surface (LRS) of the FLE is formed by a main-area and a sub-area. The light sources and LRS are distanced to each other whereby a first fraction of light is emitted towards the sub-area and a second fraction is emitted towards the main-area. The light sources, FLE, and SLE are configured to create a complete or partial, preferably adaptive, high beam light distribution with two sections. The sub-area and main-area are configured to refract impinging light, wherein refraction of light by the sub-area and main-area is such that a first intensity maximum of a first section is vertically lower in front of the lighting device than a second intensity maximum of the second section.

Abstract: Scrench tools for chainsaws are provided. A scrench tool includes a first shaft extending from a first end to a second end, wherein the first end comprises a recessed slot having an opening at the first end; and a second shaft extending away from the first shaft to a screwdriver head.

Abstract: The present disclosure is related to a field of e-bikes that discloses a bicycle frame tube, which may be a down tube of a bicycle frame. The down tube includes at the bottom-bracket-side end a battery opening facing in the longitudinal direction of the down tube such that a battery can be inserted into the opening from below. Further, the battery may be switched on and off by a switch provided at the battery. The bicycle frame tube may include a switch opening such that a mechanical switch with an operating element may be arranged in the switch opening to mechanically actuate the on/off switch of the battery. Furthermore, a charging plug as well as a charging condition indicator may be provided at the lower end of the battery or the battery housing of the battery.

Abstract: A chainsaw and fastener assembly therefor are provided. The chainsaw includes a guide bar extending from a housing and the guide bar positioned between an interior wall of the housing and a casing interior to the housing. The fastener assembly includes an outer fastener, a bar stud, and an inner fastener. The bar stud includes a plate having a first side, a second side, and an anti-rotation interface. The bar stud includes a first threaded member extending from the first side of the plate and a second threaded member extending from the second side of the plate. The plate is positioned between the guide bar and the casing. The outer fastener is threadable onto the first threaded member extending through the housing. The second threaded member is extendable through the casing and threadable onto the inner fastener.

Abstract: A detection system with a two-step homogenizing device (1) and with a receiver (42). Viewed in a field direction (54) of a photon field, the homogenizing device (1) is located between a measurement area (44) and the receiver (42). The homogenizing device (1) includes a first diffuser (10) and a second diffuser (12). The first diffuser (10) generates an intermediate photon field from an input photon field. The second diffuser (12) generates an output photon field from the intermediate photon field. The receiver (42) generates signals depending on the incident photon field.

Abstract: A bicycle frame tube which is in particular a down tube of a bicycle frame comprises a battery opening for inserting or removing a battery. Inside the bicycle frame tube a holding element for holding the battery is arranged. The holding element is at least partially elastically deformable, wherein the holding element in particular comprises two abutment elements which are elastically deformable.

Abstract: A battery unit for a bicycle having an electric motor, including a battery case having an upper side, a lower side and two sidewall several energy cells arranged in the battery case, and a battery management system electrically connected to the energy cells, where the battery management system is arranged on one of the two sides.

Abstract: The present invention relates to compositions, methods, uses and kits for combination therapies involving immunotherapies, such as adaptive cell therapy, e.g., T cell therapy, and an oncolytic virus (particularly parvovirus H-1), for treating subjects with cancer. The T cell therapy includes cells that express recombinant receptors such as chimeric antigen receptors (CARs). In some embodiments, the cancer is a solid tumor or a hematological malignancy.

Abstract: A microscopy system and method of focusing the same are disclosed herein. The microscopy system may include an objective, and imaging device, an illumination source, an epi-illumination module, and a controller. The imaging device is configured to capture a single image of a specimen positioned on a stage of the microscopy system. The illumination source is configured to illuminate the specimen positioned on the stage. The epi-illumination module includes a focusing mechanism in a first primary optical path of a light generated by the illumination source. The focusing mechanism is tilted in relation to a plane perpendicular to the first primary optical path. The controller is in communication with the illumination source. The controller is configured to focus the microscopy system based on a pattern produced by the focusing mechanism on the single image captured by the imaging device.

Abstract: A bicycle element includes a bicycle frame element. The bicycle frame element is connected to a bicycle component. Further, the bicycle frame element has a battery terminal provided thereon for the electric connection of a battery. A cable connected to the battery terminal, the cable being arranged in the bicycle frame element and in the bicycle component. A holder element is connected to the bicycle component and/or the bicycle component includes the holder element. A connector element connected to the cable is fixed in the holder element. The connector element serves for connection to an electrical component, such as a lighting means, a mobile phone or the like. The invention further relates to a bicycle system.

Abstract: A dispensing closure (10) comprising an actuator disc (20) and a base (15) is provided. The disc is pivotally mounted on the base and is pivotable between a closed position which prevents fluid product dispensing and an open position which allows product fluid dispensing. The closure comprises a transport lock (24) for preventing the disc moving from the closed to the open position.

Abstract: Chainsaws and methods of operating chainsaws are provided. A chainsaw includes a guide bar supporting a chain; a motor configured to drive the chain, the motor receiving power from an electrical energy source of the chainsaw; a sprocket operably coupled between the motor and the chain to impart driving force from the motor to the chain; and an operating device operably coupled between the motor and the sprocket and moveable between a driving state and a neutral state, wherein the chain is freely moveable in at least one direction relative to the motor when the operating device is in the neutral state.

Abstract: A dispensing closure is provided and comprises a base and a lid. The base includes a sidewall closed at one end by a top deck including a dispensing orifice. The base and lid are joined by a hinge to allow the lid to move between closed and open positions with respect to the base whereby to close and open the dispensing orifice. At the periphery of the top deck the sidewall forms or provides a raised lip. The lid closes onto the top deck and is bounded by the lip and the lid is generally flush with the lip when in the closed position.

Abstract: A trigger pump dispenser (10) comprising: a body (20); an outlet nozzle (35); a pump chamber (190); a piston (25) for defining a variable volume in the pump chamber (190) and movable between a retracted position of larger chamber volume and an inserted position of lesser chamber volume; a trigger (60) coupled with the piston (25) and movable from a starting position at which the piston (25) is in the retracted position and a depressed position at which the piston (25) is in the inserted position; biasing means (65a, 65b) is provided for biasing the trigger (60) towards its retracted position.