Patents by Inventor Patrick Shahgaldian
Patrick Shahgaldian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240181023Abstract: The present invention relates to a composition comprising a solid carrier, an enzyme immobilized on the surface of the solid carrier, a protective layer to protect the enzyme by embedding the enzyme, and a functional constituent immobilized on the surface of the protective layer.Type: ApplicationFiled: April 21, 2022Publication date: June 6, 2024Inventors: Emilie LAPRÉVOTTE, Yves Victor René DUDAL, Manon BRIAND, Emanuele CARLINI, Patrick SHAHGALDIAN
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Publication number: 20240158435Abstract: The present invention relates to a composition comprising a solid carrier, a capture moiety, a functional protein, a first linker connecting the capture moiety to the solid carrier, a second linker connecting the functional protein to the capture moiety, a first protective layer fully embedding the solid carrier, fully or partially embedding the first linker, and not or partially embedding the capture moiety, a second protective layer fully or partially embedding the capture moiety, fully embedding the second linker, and fully or partially embedding the functional protein.Type: ApplicationFiled: March 17, 2022Publication date: May 16, 2024Inventors: Patrick SHAHGALDIAN, Manon BRIAND, Philippe F.-X. CORVINI, Maria Rita CORRERO, Yves DUDAL, Ulf GRAWUNDER, Rémy GEBLEUX, Roger R. BEERLI
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Publication number: 20240011011Abstract: The present invention relates to means and methods for protecting proteins and protein-type compounds in industrial and other applications. In particular, the invention provides a composition comprising at least one protein or protein-type compound immobilized at the surface of a solid carrier embedded in a protective material. Further, the present invention relates to methods for producing such a composition and to the use thereof in, for example, therapeutic applications. In particular, the system may be used to immobilize and protect enzymes on the surface of a carrier to generate a biocatalytical composition with increased resistance to various types of stresses.Type: ApplicationFiled: July 12, 2023Publication date: January 11, 2024Inventors: Patrick Shahgaldian, Maria Rita Correro-Shahgaldian, Alessandro Cumbo, Philippe Francois-Xavier Corvini
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Publication number: 20230159964Abstract: The present invention relates to a method of producing a composition, the composition comprising a solid carrier, a functional constituent and a protective layer to protect the functional constituent.Type: ApplicationFiled: May 6, 2021Publication date: May 25, 2023Inventors: Patrick SHAHGALDIAN, Maria Rita CORRERO, Lars GROSSNIKLAUS, Anna Maria TIMM, Yves Victor René DUDAL, Philippe F.-X CORVINI
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Patent number: 10240142Abstract: A method of producing nanobiocatalysts includes: suspending a support material in a liquid medium; functionalizing a surface of the support material by mixing the suspended support material with a functionalizer for a first predefined time at a first predefined temperature, wherein a first broth results; applying a protein directly in the first broth after the first predefined time; mixing the protein with the first broth and incubating the protein for a second predefined time at a second predefined temperature, wherein a second broth results; immobilizing the incubated protein onto the functionalized surface of the support material, wherein a third broth results; filtering the third broth; and gathering a retentate of the filtering. By directly processing the first and second broths allows for providing a continuous process and production of the nanobiocatalysts, which can be optimized regarding time, water, chemical and energy consumption. Also, problems related to thixotrophy can be minimized.Type: GrantFiled: January 29, 2014Date of Patent: March 26, 2019Assignee: INOFEA AGInventors: Gregor Hommes, Philippe Corvini, Alessandro Cumbo, Patrick Shahgaldian, Yves Dudal
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Publication number: 20160168559Abstract: The present invention relates to means and methods for protecting proteins and protein-type compounds in industrial and other applications. In particular, the invention provides a composition comprising at least one protein or protein-type compound immobilized at the surface of a solid carrier embedded in a protective material. Further, the present invention relates to methods for producing such a composition and to the use thereof in, for example, therapeutic applications. In particular, the system may be used to immobilize and protect enzymes on the surface of a carrier to generate a biocatalytical composition with increased resistance to various types of stresses.Type: ApplicationFiled: July 30, 2014Publication date: June 16, 2016Inventors: Patrick Shahgaldian, Maria Rita Correro-Shahgaldian, Alessandro Cumbo, Philippe Francois-Xavier Corvini
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Publication number: 20150361416Abstract: A method of producing nanobiocatalysts includes: suspending a support material in a liquid medium; functionalizing a surface of the support material by mixing the suspended support material with a functionalizer for a first predefined time at a first predefined temperature, wherein a first broth results; applying a protein directly in the first broth after the first predefined time; mixing the protein with the first broth and incubating the protein for a second predefined time at a second predefined temperature, wherein a second broth results; immobilizing the incubated protein onto the functionalized surface of the support material, wherein a third broth results; filtering the third broth; and gathering a retentate of the filtering. By directly processing the first and second broths allows for providing a continuous process and production of the nanobiocatalysts, which can be optimized regarding time, water, chemical and energy consumption. Also, problems related to thixotrophy can be minimized.Type: ApplicationFiled: January 29, 2014Publication date: December 17, 2015Inventors: Gregor Hommes, Philippe Corvini, Alessandro Cumbo, Patrick Shahgaldian, Yves Dudal
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Patent number: 8871837Abstract: A method for preparation of a molecular recognition element comprising the steps of binding a template to a surface of a carrier material, providing a recognition material to the surface of the carrier material, initiating polymerization of the recognition material on the surface of the carrier material, stopping the polymerization of the recognition material on the surface of the carrier material, and releasing the template from the surface of the carrier material and the polymerized recognition material. The method is characterized as an aim size of individual imprints is predefined, and the polymerization of the recognition material on the surface of the carrier material is stopped when a size of individual imprints of the polymerized recognition material essentially equals the predefined aim size. This method is readily applicable for preparation of a molecular recognition element useful as a drug, catalyst, competitive affinity ligand inhibitor, competitor, agonist, antagonist or diagnostic agent.Type: GrantFiled: September 9, 2011Date of Patent: October 28, 2014Assignee: Fachhochschule Nordwestschweiz Hochschule fur LifescienceInventors: Patrick Shahgaldian, Alessandro Cumbo, Philippe Corvini
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Publication number: 20130184418Abstract: A method for preparation of a molecular recognition element comprising the steps of binding a template to a surface of a carrier material, providing a recognition material to the surface of the carrier material, initiating polymerization of the recognition material on the surface of the carrier material, stopping the polymerization of the recognition material on the surface of the carrier material, and releasing the template from the surface of the carrier material and the polymerized recognition material. The method is characterized as an aim size of individual imprints is predefined, and the polymerization of the recognition material on the surface of the carrier material is stopped when a size of individual imprints of the polymerized recognition material essentially equals the predefined aim size. This method is readily applicable for preparation of a molecular recognition element useful as a drug, catalyst, competitive affinity ligand inhibitor, competitor, agonist, antagonist or diagnostic agent.Type: ApplicationFiled: September 9, 2011Publication date: July 18, 2013Applicant: Fachhochschule Nordwestschweiz Hochschule Fur LifescienceInventors: Patrick Shahgaldian, Alessandro Cumbo, Philippe Corvini
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Patent number: 7695918Abstract: A process of concentration by precipitation of PrPsc for detecting or diagnosing PrPsc, wherein a tissue or biological fluid stemming from or obtained from an animal or human organism is brought together with an antibiotic from the family of aminoglycosides, preferably streptomycin or one of its derivatives. The use of such an antibiotic for eliminating PrPsc from a tissue or biological fluid and a kit for diagnosing pathologies associated with the presence of PrPsc is also disclosed.Type: GrantFiled: June 13, 2005Date of Patent: April 13, 2010Assignees: Agence Francaise de Securite Sanitaire des Aliments-AFSSA, Centre National de la Recherche Scientifique-CNRS, Universite Claude Bernard Lyon, BiomerieuxInventors: Aly Moussa, Anthony William Coleman, Anna Bencsik-Reynier, Patrick Shahgaldian, Hervé Perron, Ambroise Martin
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Publication number: 20070154885Abstract: A process for detecting the forms of the prion pathogens responsible for subacute, transmissible, spongiform encephalopathies, including a macrocyclic adjuvant ligand (AML), free or bound to a support, that is added to a biological sample capable of containing PrPsc, the resulting suspension then being reacted with an anti-PrPsc antibody, and the presence of PrP is then detected.Type: ApplicationFiled: February 1, 2007Publication date: July 5, 2007Applicants: Agence Francaise de Securite Sanitaire Des Aliments-AFSSA, Centre National de la Recherche Scientifique-CNRS, Universite Claude Bernard LyonInventors: Aly Moussa, Anthony Coleman, Patrick Shahgaldian, Eric Da Silva, Ambroise Martin, Adina Lazar, Edwige Leclere, Marilyne Dupin, Herve Perron
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Patent number: 7217530Abstract: A process for detecting the forms of the prion pathogens responsible for subacute, transmissible, spongiform encephalopathies, including a macrocyclic adjuvant ligand (AML), free or bound to a support, that is added to a biological sample capable of containing PrPsc, the resulting suspension then being reacted with an anti-PrPsc antibody, and the presence of PrP is then detected.Type: GrantFiled: June 9, 2005Date of Patent: May 15, 2007Assignees: Agence Francaise de Securite Sanitaire des Aliments-AFSSA, Centre National de la Recherche Scientifique-CNRS, Universite Claude Bernard Lyon and BiomerieuxInventors: Aly Moussa, Anthony William Coleman, Patrick Shahgaldian, Eric Da Silva, Ambroise Martin, Adina Nicoleta Lazar, Edwige Leclere, Marilyne Dupin, Herve Perron
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Publication number: 20060019311Abstract: A process for detecting the forms of the prion pathogens responsible for subacute, transmissible, spongiform encephalopathies, including a macrocyclic adjuvant ligand (AML), free or bound to a support, that is added to a biological sample capable of containing PrPsc, the resulting suspension then being reacted with an anti-PrPsc antibody, and the presence of PrP is then detected.Type: ApplicationFiled: June 9, 2005Publication date: January 26, 2006Applicants: Agence Francaise de Securite Sanitaire des Aliments-AFSSA, an organization of France, Centre National de la Recherche Scientifique-CNRS, an organization of France, Universite Claude Bernard Lyon, an organization of France, Biomerieux, an organization of FranceInventors: Aly Moussa, Anthony Coleman, Patrick Shahgaldian, Eric Silva, Ambroise Martin, Adina Lazar, Edwige Leclere, Marilyne Dupin, Herve Perron
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Publication number: 20060014215Abstract: A process of concentration by precipitation of PrPsc for detecting or diagnosing PrPsc, wherein a tissue or biological fluid stemming from or obtained from an animal or human organism is brought together with an antibiotic from the family of aminoglycosides, preferably streptomycin or one of its derivatives. The use of such an antibiotic for eliminating PrPsc from a tissue or biological fluid and a kit for diagnosing pathologies associated with the presence of PrPsc is also disclosed.Type: ApplicationFiled: June 13, 2005Publication date: January 19, 2006Applicants: Agence Francaise de Securite Sanitaire des Aliments-AFSSA, an organization of France, Centre National de la Recherche Scientifique-CNRS, an organization of France, Universite Claude Bernard Lyon, an organization of France, Biomerieux, an organization of FranceInventors: Aly Moussa, Anthony Coleman, Anna Bencsik-Reynier, Patrick Shahgaldian, Herve Perron, Ambroise Martin