Patents by Inventor Patrick Sharpe

Patrick Sharpe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250099478
    Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angioedema, uveitis, posterior uveitis, wet age-related macular degeneration, diabetic macular edema, diabetic retinopathy and retinal vein occlusion. The compounds are selective inhibitors of plasma kallikrein.
    Type: Application
    Filed: January 23, 2023
    Publication date: March 27, 2025
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Anthony K. Ogawa, Christopher J. Sinz, Alan C. Cheng, Ying-Duo Gao, Song Yang, Jianming Bao, Rohan Rajiv Merchant, Natalija Cernaka, Phillip Patrick Sharp, Jovan Alexander Lopez, Dong Xiao, Haiqun Tang, Maoqun Tian, Mihir B. Mandal, Jiafang He
  • Publication number: 20240326134
    Abstract: In a method for treating combustible and/or reactive particles (34) which have been separated from a gas stream (32) by means of a separation device (36) an oxidizing agent is supplied to an atmosphere surrounding the particles (34) so as to cause a passivating oxidation of at least a part of the particles (34). A content of the oxidizing agent in the atmosphere surrounding the particles (34) is detected and the supply of the oxidizing agent to the atmosphere surrounding the particles (34) is controlled in dependence on the detected content of the oxidizing agent in the atmosphere surrounding the particles (34).
    Type: Application
    Filed: June 13, 2024
    Publication date: October 3, 2024
    Inventors: Matthew Schulz-Sciberras, Patrick Sharp
  • Patent number: 12053824
    Abstract: In a method for treating combustible and/or reactive particles (34) which have been separated from a gas stream (32) by means of a separation device (36) an oxidizing agent is supplied to an atmosphere surrounding the particles (34) so as to cause a passivating oxidation of at least a part of the particles (34). A content of the oxidizing agent in the atmosphere surrounding the particles (34) is detected and the supply of the oxidizing agent to the atmosphere surrounding the particles (34) is controlled in dependence on the detected content of the oxidizing agent in the atmosphere surrounding the particles (34).
    Type: Grant
    Filed: November 11, 2020
    Date of Patent: August 6, 2024
    Assignee: Nikon SLM Slolutions AG
    Inventors: Matthew Schulz-Sciberras, Patrick Sharp
  • Publication number: 20240245675
    Abstract: The present invention features compounds useful in the inhibition of the secretion of proteins. The compounds of the invention can be used in methods for treating diseases associated with protein secretion, and in methods for inhibiting protein secretion.
    Type: Application
    Filed: January 29, 2024
    Publication date: July 25, 2024
    Inventors: Jordi MATA-FINK, Phillip Patrick SHARP, Raman TALWAR
  • Publication number: 20240190892
    Abstract: The present invention provides a compound of formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angioedema, uveitis, posterior uveitis, wet age-related macular degeneration, diabetic macular edema, diabetic retinopathy and retinal vein occlusion. The compounds are selective inhibitors of plasma kallikrein.
    Type: Application
    Filed: March 16, 2022
    Publication date: June 13, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Natalija Cernaka, Anthony K. Ogawa, Alan C. Cheng, Jianming Bao, Phillip Patrick Sharp, Jovan Alexander Lopez, Dong Xiao, Haiqun Tang
  • Publication number: 20240025917
    Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angioedema, uveitis, posterior uveitis, wet age related macular edema, diabetic macular edema, diabetic retinopathy and retinal vein occlusion. The compounds are selective inhibitors of plasma kallikrein.
    Type: Application
    Filed: November 18, 2021
    Publication date: January 25, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Jianming Bao, Natalija Cernaka, Alan C. Cheng, Ying-Duo Gao, Salman Jabri, Jovan Alexander Lopez, Rohan Merchant, Anthony Ken Ogawa, Skylar K. Osler, Christopher J. Sinz, Phillip Patrick Sharp, Haiqun Tang, Maoqun Tian, Dong Xiao, Song Yang
  • Publication number: 20230348428
    Abstract: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angioedema, uveitis, posterior uveitis, wet age related macular edema, diabetic macular edema, diabetic retinopathy and retinal vein occlusion. The compounds are selective inhibitors of plasma kallikrein.
    Type: Application
    Filed: July 6, 2021
    Publication date: November 2, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Jacqueline D. HICKS, Rongze Kuang, Christopher J. Sinz, Matthew J. Lombardo, Jovan Alexander Lopez, Rohan Rajiv Merchant, Phillip Patrick Sharp, Zhicai Wu, Zhiqiang Zhao, Alan C. Cheng, Song Yang, Jianming Bao, Maoqun Tian, Galen Paul Shearn-Nance
  • Publication number: 20230067216
    Abstract: In a method of treating a gas stream (32) containing combustible and/or reactive particles (34) at least a part of the particles (34) contained in the gas stream (32) is separated from the gas stream (32) by means of a separation device (36). The particles (34) separated from the gas stream (32) by means of the separation device (36) are supplied to a collecting vessel (40). The supply of particles (34) to the collecting vessel (40) is interrupted. A flame retardant material (57) is supplied to the collecting vessel (40) so as to form a cover layer of flame retardant material (57) on the particles (34) contained in the collecting vessel (40).
    Type: Application
    Filed: September 2, 2020
    Publication date: March 2, 2023
    Inventors: Matthew Schulz-Sciberras, Patrick Sharp, Isabell Huebinger
  • Patent number: 11339193
    Abstract: Provided herein are compounds that inhibit protein secretion, e.g., via inhibition of Sec61. Also provided are compositions of the inhibitor compounds, and methods of using these inhibitors. The compounds disclosed herein can be used, e.g., for the treatment of cancer, arthritis, and/or inflammation.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: May 24, 2022
    Assignees: KEZAR LIFE SCIENCES, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Dustin McMinn, John William Taunton, Phillip Patrick Sharp
  • Publication number: 20210138397
    Abstract: In a method for treating combustible and/or reactive particles (34) which have been separated from a gas stream (32) by means of a separation device (36) an oxidizing agent is supplied to an atmosphere surrounding the particles (34) so as to cause a passivating oxidation of at least a part of the particles (34). A content of the oxidizing agent in the atmosphere surrounding the particles (34) is detected and the supply of the oxidizing agent to the atmosphere surrounding the particles (34) is controlled in dependence on the detected content of the oxidizing agent in the atmosphere surrounding the particles (34).
    Type: Application
    Filed: November 11, 2020
    Publication date: May 13, 2021
    Inventors: Matthew Schulz-Sciberras, Patrick Sharp
  • Publication number: 20210017233
    Abstract: Provided herein are compounds that inhibit protein secretion, e.g., via inhibition of Sec61. Also provided are compositions of the inhibitor compounds, and methods of using these inhibitors. The compounds disclosed herein can be used, e.g., for the treatment of cancer, arthritis, and/or inflammation.
    Type: Application
    Filed: March 29, 2019
    Publication date: January 21, 2021
    Inventors: Dustin McMinn, John William Taunton, Phillip Patrick Sharp
  • Patent number: 10167292
    Abstract: The present invention provides novel benzodiazepine derivatives of Formula I or pharmaceutically acceptable derivatives, polymorphs, salts or prodrugs thereof. Said compounds have potential as bromodomain (BRD) inhibitors.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: January 1, 2019
    Assignee: Catalyst Therapeutics Pty Ltd.
    Inventors: Chris Burns, Jean-Marc Garnier, Phillip Patrick Sharp, John Feutrill, Anthony Cuzzupe
  • Publication number: 20180230153
    Abstract: The present invention provides novel benzodiazepine derivatives of Formula I or pharmaceutically acceptable derivatives, polymorphs, salts or prodrugs thereof. Said compounds have potential as bromodomain (BRD) inhibitors.
    Type: Application
    Filed: August 4, 2016
    Publication date: August 16, 2018
    Inventors: Chris Burns, Jean-Marc Garnier, Phillip Patrick Sharp, John Feutrill, Anthony Cuzzupe
  • Publication number: 20160282408
    Abstract: A system including an embedded logic analyzer block having an input receiving a plurality of signals from a system under test, and a trigger event block detecting an occurrence of an event based in part upon the plurality of signals. The system further includes a block with a first input receiving one or more of the plurality of signals, a second input receiving a signal based upon the detection of the occurrence of the event, circuitry generating a distinct set test signals based on the signals at the first input and second input of the block, the distinct set of test signals being different from the plurality of signals appearing at the input of the embedded logic analyzer block, and an output providing the generated distinct set of test signals to the embedded logic analyzer block as additional test signals for at least one of sampling thereof and event triggering.
    Type: Application
    Filed: June 8, 2016
    Publication date: September 29, 2016
    Inventors: Eric David Langevin, James Patrick Sharpe, James Ray Bailey
  • Patent number: 9170901
    Abstract: A system for testing or debugging a device under test having an embedded logic analyzer. In one embodiment, the system includes software stored in non-transitory memory for testing a device under test having an embedded logic analyzer, the software program product having instructions which, when executed by a computing device associated with the device under test cause the computing device to reconstruct signals of interest in the device under test based at least in part upon signals captured by the embedded logic analyzer during the test or debug session, and cause the computing device to display the reconstructed signals of interest to a user of the computing device.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: October 27, 2015
    Assignee: Lexmark International, Inc.
    Inventors: James Ray Bailey, Christopher W Case, James Patrick Sharpe, James Alan Ward, Michael Anthony Marra, III
  • Patent number: D776278
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: January 10, 2017
    Assignee: MALLINCKRODT HOSPITAL PRODUCTS IP LIMITED
    Inventors: David Newman, Patrick Sharpe, David Strait
  • Patent number: D776279
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: January 10, 2017
    Assignee: MALLINCKRODT HOSPITAL PRODUCTS IP LIMITED
    Inventors: David Newman, Brian Paap, Patrick Sharpe, David Strait
  • Patent number: D797935
    Type: Grant
    Filed: September 20, 2016
    Date of Patent: September 19, 2017
    Assignee: Mallinckrodt Hospital Products IP Limited
    Inventors: David Newman, Patrick Sharpe, David Strait
  • Patent number: D807510
    Type: Grant
    Filed: September 20, 2016
    Date of Patent: January 9, 2018
    Assignee: MALLINCKRODT HOSPITAL PRODUCTS IP LIMITED
    Inventors: David Newman, Brian Paap, Patrick Sharpe, David Strait
  • Patent number: D823472
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: July 17, 2018
    Assignee: Mallinckrodt Hospital Products IP Limited
    Inventors: David Newman, Patrick Sharpe, David Strait