Abstract: Provided herein are composition and methods for characterizing and treating disease. In particular, provided herein are compositions and methods for characterizing and treating disease (e.g., cancer) associated with activation of LINE-1 retroelements.

Abstract: The present invention provides a method for treating a subject having a clinical condition associated with increased level of L1 expression. The method generally includes determining the expression level of L1 in a subject and administering a TGF-?1 inhibitor to a subject having an increased level of L1 expression. The clinical conditions that can be treated using the method of the invention include, but are not limited to, cancer, chronic obstructive pulmonary disease (COPD), atherosclerosis and pulmonary vascular disease as well as other fibrotic and inflammatory diseases.

Abstract: A method for monitoring consumption of at least one consumable in a mass transfer system. The method includes providing at least one accurate mass transfer apparatus configured to provide mass transfer of a gas into a liquid to generate a liquid output, wherein the relative amounts of liquid and gas are set, and for each mass transfer apparatus: measuring the amount of liquid output, and determining, based on the amount of liquid output and the relative amounts of liquid and gas, a quantity of at least one of the gas and liquid consumed in that mass transfer apparatus.

Abstract: According to one aspect, a system for controlling mass transfer of a gas into a liquid. The system includes a mass transfer apparatus configured to provide the mass transfer of the gas into the liquid, a temperature sensor configured to monitor the temperature of the liquid provided to the mass transfer apparatus, a pressure sensor configured to monitor the pressure within the mass transfer apparatus, and a control unit configured to communicate with the temperature sensor and the pressure sensor. In response, the control unit adjusts the pressure within the mass transfer apparatus to encourage reaching an equilibrium condition within the mass transfer apparatus and provide for consistent gas absorption into the liquid.

Abstract: A communications system reduces downconverter inaccuracies in time-domain measurements or samples of received microwave communications I and Q complex signals by converting received signal to baseband taking measurements or samples of the I and Q waveforms at differing phase shifts of a demodulating carrier signal for a local oscillator or carrier tracking loop used during downconversion so that I and Q imbalances may be detected and removed by lowpass equivalent averaging for improved characterization of downconverters or for improved signal reception. In the preferred form, the phase shifts are 0 and ?/2 for a conventional measurement, and then at ?, and ?+?/2, with ?=?/4+m?/2 for an integer m for the second measurement where I and Q imbalances and baseband nonlinearities are indicated by differences between the two measured or sampled signals, where ? provides for optimum error detection for reducing the errors by averaging the measurements.

Abstract: A communications system redness downconverter inaccuracies in time-domain measurements or samples of received microwave communications I and Q complex signals by converting received signal to baseband taking measurements or samples of the I and Q waveforms at differing phase shifts of a demodulating carrier signal for a local oscillator or carrier tracking loop used during downconversion so that I and Q imbalances may be detected and removed by lowpass equivalent averaging for improved characterization of downconverters or for improved signal reception. In the preferred form, the phase shifts are 0 and ?/2 for a conventional measurement, and then at ?, and ?+?/2, with ?=?/4+m?/2 for an integer m for the second measurement where I and Q imbalances and baseband monlinearities are indicated by differences between the two measured or sampled signals, where ? provides for optimum error detection for reducing the errors by averaging the measurements.

Abstract: A communications system reduces downconverter inaccuracies in time-domain measurements or samples of received microwave communications I and Q complex signals by converting received signal to baseband taking measurements or samples of the I and Q waveforms at differing phase shifts of a demodulating carrier signal for a local oscillator or carrier tracking loop used during downconversion so that I and Q imbalances may be detected and removed by lowpass equivalent averaging for improved characterization of downconverters or for improved signal reception. In the preferred form, the phase shifts are 0 and ?/2 for a conventional measurement, and then at ?, and ?+?/2, with ?=?/4+m?/2 for an integer m for the second measurement where I and Q imbalances and baseband nonlinearities are indicated by differences between the two measured or sampled signals, where ? provides for optimum error detection for reducing the errors by averaging the measurements.

Abstract: A time-domain baseband measurement method measures modulated microwave signals typically used in communication systems by converting microwave signals to baseband before measurement for improved accuracy compared to direct measurement at the microwave frequency. A downconverting receiver is first characterized using a prior characterization method and then the modulated microwave signal is applied to the downconverting receiver and the response of the downconverting receiver is removed to provide an accurate characterization of the modulated microwave signal. Such an accurate measurement of the modulated microwave signal can be used for communications system performance verification as well as for characterizing communications devices and systems. One particular application is the measurement of input/output characteristics of nonlinear power amplifiers using such modulated microwave signals.

Abstract: A high frequency anharmonic oscillator provides a broad band chaotic oscillation with a noise-like spectra. The oscillator output signal is suitable for modulation by data providing for improved secure communication. The chaotic oscillator is based upon a forced second order Duffing equation that is tolerant of delay in the feedback path for high frequency operation.

Abstract: A three-pair measurement method determines the amplitude and phase transmission response of frequency translating devices including a device under test and two test devices using a vector network analyzer and a controller where one of the devices has reciprocal frequency response characteristics. The characterization of single sideband and double sideband devices such as mixers, is preferably performed by combining data from analyzer two-port swept measurements. The measurement method provides a low-pass equivalent transmission response of the devices.

Abstract: A three-pair measurement method determines the amplitude and phase transmission response of frequency translating devices including a device under test and two test devices using a vector network analyzer and a controller where one of the devices has reciprocal frequency response characteristics. The characterization of single sideband and double sideband devices such as mixers, is preferably performed by combining data from analyzer two-port swept measurements. The measurement method provides a low-pass equivalent transmission response of the devices.

Abstract: A three-pair measurement method determines the amplitude and phase transmission response of frequency translating devices including a device under test and two test devices using a vector network analyzer and a controller where one of the devices has reciprocal frequency response characteristics. The characterization of single sideband and double sideband devices such as mixers, is preferably performed by combining data from analyzer two-port swept measurements. The measurement method provides a low-pass equivalent transmission response of the devices.